@article{98cc7824-d90f-446e-815b-efa402477c06,
  abstract     = {{<p>Introduction: Traumatic axonal injury (TAI), often caused by rapid rotational forces and high-energy accidents, is common in severe traumatic brain injury (sTBI). The intracranial pressure (ICP) dynamics are often unpredictable, and the need for ICP monitoring remains debated. Research question: What is the incidence of ICP elevation in patients with TAI, and how often is escalated ICP-lowering treatment required? Material and methods: Retrospectively, sTBI patients treated between 2007 and 2022 with TAI lesions at the grey–white matter interface, corpus callosum, deep central structures, and/or brainstem, on magnetic resonance imaging (MRI) were included. Patients with ICP elevation despite baseline management were treated according to the Lund Concept, including beta-blockers, clonidine, and albumin. Decompressive craniectomy (DC) or high-dose barbiturate infusion was reserved for refractory ICP elevation. Results: Thirty-one TAI patients (15 women and 16 men) presented with a median Glasgow Coma Scale motor score of 2 (range 1–6). All patients had TAI lesion in the grey-white interface, 27 patients also in the corpus callosum, and 16 patients had brainstem lesions. Elevated ICP was observed in 16 patients (52 %), of whom 4/16 (25 %) received either DC (n = 2), high-dose barbiturates (n = 1) or both (n = 1). Discussion and conclusion: The risk of increased ICP in TAI patients has been debated. Our present results, showing that 52 % of TAI patients experienced elevated ICP requiring escalated ICP-lowering strategies, argue that ICP monitoring is required in TAI. The impact of increased ICP on outcome following TAI should be explored in future studies.</p>}},
  author       = {{Westerberg, Gustaf and Hossain, Iftakher and Drake, Mattias and Tsitsopoulos, Parmenion P. and Marklund, Niklas}},
  issn         = {{2772-5294}},
  keywords     = {{Intracranial hypertension; Intracranial pressure; Neurocritical care; Outcome; Traumatic axonal injury; Traumatic brain injury}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Brain and Spine}},
  title        = {{Increased intracranial pressure in severe traumatic axonal injury patients - A retrospective single-center study}},
  url          = {{http://dx.doi.org/10.1016/j.bas.2026.105945}},
  doi          = {{10.1016/j.bas.2026.105945}},
  volume       = {{6}},
  year         = {{2026}},
}