@article{9c1c01a4-2fdc-4d3f-85dc-4411bf43b564,
  abstract     = {{<p>We developed a collagen microfiber-based 3D cancer tissue model that included monocytes. Using a sedimentation culture method, normal human dermal fibroblasts, endothelial cells, cancer cells, and THP-1 cells—that is, the human monocytes cell line—were cocultured under a high collagen density. THP-1 cells were differentiated into macrophages and showed M2-like polarization in the 3D tumor microenvironment. This model was further applicable to drug evaluation by demonstrating the pH-responsive cytotoxicity of poly(vinyl alcohol)–ursodeoxycholic acid15.</p>}},
  author       = {{Moroishi, Kazuki and Hermodsson, Tova and Greiff, Lennart and Lindstedt, Malin and Matsusaki, Michiya}},
  issn         = {{0366-7022}},
  keywords     = {{3D cancer–stromal tissue; collagen microfiber (CMF); monocyte differentiation}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  publisher    = {{Oxford University Press}},
  series       = {{Chemistry Letters}},
  title        = {{Evaluation of cancer cell membrane-disruption property of poly(vinyl alcohol)–ursodeoxycholic acid using 3D cancer–stromal models with macrophages}},
  url          = {{http://dx.doi.org/10.1093/chemle/upag029}},
  doi          = {{10.1093/chemle/upag029}},
  volume       = {{55}},
  year         = {{2026}},
}