@article{ada39f73-1c4a-4f01-bbe8-00e0a695d3c1,
  abstract     = {{<p>Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells.</p>}},
  author       = {{Pulat, Sultan and Yang, Inho and Lee, Jihye and Hwang, Sunghoon and Zhou, Rui and Gamage, Chathurika D B and Varlı, Mücahit and Taş, İsa and Yang, Yi and Park, So-Yeon and Hong, Ahreum and Kim, Jeong-Hyeon and Oh, Dong-Chan and Kim, Hangun and Nam, Sang-Jip and Kang, Heonjoong}},
  issn         = {{1660-3397}},
  keywords     = {{Humans; Cell Line, Tumor; Caco-2 Cells; Streptomyces/metabolism; A549 Cells; rho GTP-Binding Proteins/metabolism; Cell Movement; Epithelial-Mesenchymal Transition; Neoplasms}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  publisher    = {{MDPI AG}},
  series       = {{Marine Drugs}},
  title        = {{Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells}},
  url          = {{http://dx.doi.org/10.3390/md22020088}},
  doi          = {{10.3390/md22020088}},
  volume       = {{22}},
  year         = {{2024}},
}