@article{b0eb59ad-cc5e-4a5e-a1d2-8f32b19bccb5,
  abstract     = {{<p>INTRODUCTION: Since sleep disturbance is a modifiable risk factor for Alzheimer's disease (AD), we tested associations between sleep and AD pathology in cognitively unimpaired (CU) persons. METHODS: We included 223 participants from the PREVENT-AD cohort with self-reported measures of sleep, objective actigraphy measures of sleep, and positron emission tomography (PET) scans for AD pathology quantification. Repeated PET scans (mean follow-up: 4.31 ± 0.55 years) were available for 103 participants. We conducted robust linear models (RLM) for cross-sectional analyses and RLMs using the annual change in AD pathology for longitudinal analyses. RESULTS: All actigraphy-based sleep variability measures were associated with tau burden (duration: β = 0.121 [95% confidence interval {CI} = 0.010; 0.232], p = 0.034; efficiency: 0.122 [0.010; 0.235], 0.033; fragmentation: 0.115 [0.010; 0.221], 0.033). Greater variability in sleep fragmentation was also associated with amyloid burden (0.074 [0.008; 0.140], 0.028), and variability in sleep efficiency portended amyloid burden and faster accumulation over time (0.075 [0.009; 0.141], 0.026; 0.164 [0.008; 0.320], 0.039; respectively). DISCUSSION: Irregularity in sleep patterns is associated with higher pathological burden and faster amyloid accumulation.</p>}},
  author       = {{Mohammediyan, Bery and Baril, Andrée Ann and Fajardo Valdez, Alfonso and St-Onge, Frédéric and Pichet Binette, Alexa and Carrier, Julie and Geddes, Maiya R. and Ducharme, Simon and Montembeault, Maxime and Soucy, Jean Paul and Breitner, John and Poirier, Judes and Villeneuve, Sylvia}},
  issn         = {{1552-5260}},
  keywords     = {{amyloid; circadian rhythms; PET; sleep; tau}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Longitudinal association between sleep and Alzheimer's pathology}},
  url          = {{http://dx.doi.org/10.1002/alz.71228}},
  doi          = {{10.1002/alz.71228}},
  volume       = {{22}},
  year         = {{2026}},
}