@article{c2c00526-eaec-461d-916f-d2e6a225fdc3,
  abstract     = {{Anxiety plays a key role in guiding behavior in response to potential <br>
threats. Anxiety is mediated by the activation of pyramidal neurons in <br>
the ventral hippocampus (vH), whose activity is controlled by GABAergic <br>
inhibitory interneurons. However, how different vH interneurons might <br>
contribute to anxiety-related processes is unclear. Here, we investigate<br>
 the role of vH parvalbumin (PV)-expressing interneurons while mice <br>
transition from safe to more anxiogenic compartments of the elevated <br>
plus maze (EPM). We find that vH PV interneurons increase their activity<br>
 in anxiogenic EPM compartments concomitant with dynamic changes in <br>
inhibitory interactions between PV interneurons and pyramidal neurons. <br>
By optogenetically inhibiting PV interneurons, we induce an increase in <br>
the activity of vH pyramidal neurons and persistent anxiety. <br>
Collectively, our results suggest that vH inhibitory microcircuits may <br>
act as a trigger for enduring anxiety states.<br>
    <p/>}},
  author       = {{Volitaki, Emmanouela and Forro, Thomas and Li, Kaizhen and Nevian, Thomas and Ciocchi, Stéphane}},
  issn         = {{2211-1247}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{Cell Press}},
  series       = {{Cell Reports}},
  title        = {{Activity of ventral hippocampal parvalbumin interneurons during anxiety}},
  url          = {{http://dx.doi.org/10.1016/j.celrep.2024.114295}},
  doi          = {{10.1016/j.celrep.2024.114295}},
  volume       = {{43}},
  year         = {{2024}},
}