INTRODUCTION: We assessed the accuracy of the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) for clinical staging in Swedish primary care.
METHODS: Participants from the Swedish BioFINDER Primary Care study were included. Discriminative performance of the A-IADL-Q was evaluated using receiver operating curves. Multinomial and linear regression models assessed associations among A-IADL-Q scores, clinical stage, demographics, cognition, and comorbidities.
RESULTS: Among 623 patients, 148 (23.8%) had subjective cognitive decline (SCD), 274 (43.9%) mild cognitive impairment (MCI), and 201 (32.3%) dementia with a mean (standard deviation) age of 76.7 (7.3). The area under the curve (95% confidence interval) for discriminating between SCD versus MCI/dementia was 0.89 (0.86-0.91) and for SCD/MCI versus dementia 0.89 (0.87-0.92). Age (
β = -0.25), Mini-Mental State Examination (
β = 0.91) and Montreal Cognitive Assessment (
β = 0.57), but no other demographics and comorbidities, were associated with the A-IADL-Q.
DISCUSSION: The A-IADL-Q may help primary care physicians determine clinical stage and shows promise for use to adequately refer patients to secondary or tertiary care.
}}, author = {{Fawad, Ayesha and van der Landen, Sophie M and Tideman, Pontus and van der Putten-Toorenburg, Angela and Butterbrod, Elke and Smith, Ruben and van Westen, Danielle and Calling, Susanna and Midlöv, Patrik and Mattsson-Carlgren, Niklas and Borgström Bolmsjö, Beata and Stomrud, Erik and Nilsson, Maria H and Hansson, Oskar and Sikkes, Sietske A M and Palmqvist, Sebastian}}, issn = {{2352-8729}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}}, title = {{Clinical staging in Swedish primary care using the Amsterdam Instrumental Activities of Daily Living Questionnaire}}, url = {{http://dx.doi.org/10.1002/dad2.70344}}, doi = {{10.1002/dad2.70344}}, volume = {{18}}, year = {{2026}}, }