@article{e93baecc-bbdf-4006-b58a-5d6a47a59259,
  abstract     = {{<p>Mannosyl β-C-1 amidotriazoles have previously been reported to have higher selectivity for galectin-9N (N-terminal domain) than the corresponding galactoside C3 amidotriazoles have, which were more selective for galectin-3. This study further investigated this by synthesis of mono- and bis-aryltriazolyl mannoside analogues to known high-affinity galectin-3 galactosyl-derived inhibitors. Following synthesis, affinity measurements using competititve fluorescence polarization assays were performed which indicated low affinity of the bis-aryltriazolyl mannosyls, while the mono-aryltriazolyl mannosyls analogs possessed improved affinity, albeit with lower and selectivity. From conformational calculations it was implied that the weak-binding bis-aryltriazolyl mannosyl analogues do not find the same conformation and binding pose as the parent galactoside compounds.</p>}},
  author       = {{Sjövall, Fredrik and Nilsson, Ulf J.}},
  issn         = {{1439-4227}},
  keywords     = {{Galectins/antagonists & inhibitors; Triazoles/chemistry; Galectin 3/antagonists & inhibitors; Humans; Blood Proteins; Galactosides/chemistry; Protein Domains/drug effects}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{7}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{ChemBioChem}},
  title        = {{β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors}},
  url          = {{http://dx.doi.org/10.1002/cbic.70319}},
  doi          = {{10.1002/cbic.70319}},
  volume       = {{27}},
  year         = {{2026}},
}