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- 2020
- AAV Production Everywhere : A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction
- 2019
- Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain
-
Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease
Rosenblad, Carl LU ; Li, Qin ; Pioli, Elsa Y ; Dovero, Sandra ; Antunes, André S L M ; Agúndez, Leticia ; Bardelli, Martino ; Linden, R Michael ; Henckaerts, Els and Björklund, Anders LU
, et al.
(2019)
In Brain : a journal of neurology
p.2402-2416
Mark
-
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy
Espa, Elena LU ; Clemensson, Erik K.H. LU ; Luk, Kelvin C. ; Heuer, Andreas LU ; Björklund, Tomas LU and Cenci, M. Angela LU
(2019)
In Movement Disorders
34(11).
p.1699-1710
Mark
-
A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
Davidsson, Marcus LU ; Wang, Gang LU ; Aldrin-Kirk, Patrick LU ; Cardoso, Tiago LU ; Nolbrant, Sara LU ; Hartnor, Morgan ; Mudannayake, Janitha LU ; Parmar, Malin LU
and Björklund, Tomas
LU
(2019)
In Proceedings of the National Academy of Sciences of the United States of America
116(52).
p.27053-27062
Mark
- 2018
-
Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing
Davidsson, Marcus LU ; Díaz-Fernández, Paula ; Torroba, Marcos ; Schwich, Oliver D. ; Aldrin-Kirk, Patrick LU ; Quintino, Luis LU
; Heuer, Andreas
LU
; Wang, Gang
LU
; Lundberg, Cecilia
LU
and Björklund, Tomas
LU
(2018)
In RNA
24(5).
p.673-687
Mark
- Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum
- Repairing the brain : Gene therapy
- A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency
- 2016
- Expression of Multiple Functional RNAs or Proteins from One Viral Vector.
- Identification of multiple QTLs linked to neuropathology in the engrailed-1 heterozygous mouse model of Parkinson's disease
- Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level
- A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing
-
DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor
Aldrin-Kirk, Patrick LU ; Heuer, Andreas LU ; Wang, Gang LU ; Mattsson, Bengt LU ; Lundblad, Martin LU ; Parmar, Malin LU
and Björklund, Tomas
LU
(2016)
In Neuron
90(5).
p.955-968
Mark
- 2014
- Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.
- 2013
-
Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.
Cederfjäll, Erik LU ; Nilsson, Nathalie LU ; Sahin, Gurdal LU
; Chu, Yaping
; Nikitidou, Elisabeth
LU
; Björklund, Tomas
LU
; Kordower, Jeffrey H
and Kirik, Deniz
LU
(2013)
In Scientific Reports
3.
Mark
- A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.
- 2012
- Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
-
Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.
Cederfjäll, Erik LU ; Sahin, Gurdal LU
; Kirik, Deniz
LU
and Björklund, Tomas
LU
(2012)
In Molecular Therapy
20(7).
p.1315-1326
Mark
- 2011
-
Gene therapy for Parkinson's disease shows promise.
Björklund, Anders LU
and Björklund, Tomas
LU
(2011)
In Science Translational Medicine
3(79).
p.1-79
Mark
- Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
- 2010
-
A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System
Iwamoto, Mari ; Björklund, Tomas LU ; Lundberg, Cecilia LU
; Kirik, Deniz
LU
and Wandless, Thomas J.
(2010)
In Chemistry and Biology
17(9).
p.981-988
Mark
- Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates
- Gene therapy for dopamine replacement.
- Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.
- Gene therapy for Parkinson's disease.
- 2009
-
Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons.
Ulusoy, Ayse LU ; Sahin, Gurdal LU
; Björklund, Tomas
LU
; Aebischer, Patrick
and Kirik, Deniz
LU
(2009)
In Molecular Therapy
17.
p.1574-1584
Mark
- Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
- Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application
- Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy
-
Gene therapy for dopamine replacement in Parkinson's disease.
Björklund, Anders LU
; Björklund, Tomas
LU
and Kirik, Deniz
LU
(2009)
In Science Translational Medicine
1(2).
p.2-2
Mark
- Scientific rationale for the development of gene therapy strategies for Parkinson's disease.
- 2008
- In vivo gene delivery for development of mammalian models for Parkinson's disease
-
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.
Lundberg, Cecilia LU
; Björklund, Tomas
LU
; Carlsson, Thomas
LU
; Jakobsson, Johan
LU
; Hantraye, Philippe
; Déglon, Nicole
and Kirik, Deniz
LU
(2008)
In Current Gene Therapy
8(6).
p.461-473
Mark
- Future Cell- and Gene-Based Therapies for Parkinson's Disease
- 2007
- Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
- Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.
- 2006
- Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls
- 2005
- Imaging in cell-based therapy for neurodegenerative diseases.