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2023
Mark The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans
Luukkonen, Panu K. ; Porthan, Kimmo ; Ahlholm, Noora ; Rosqvist, Fredrik ; Dufour, Sylvie ; Zhang, Xian Man ; Lehtimäki, Tiina E. ; Seppänen, Wenla ; Orho-Melander, Marju ^LU and Hodson, Leanne , et al. (2023) In Cell Metabolism 35(11). p.5-1896
- Contribution to journal › Article
Mark Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis
Luukkonen, Panu K. ; Sakuma, Ikki ; Gaspar, Rafael C. ; Mooring, Meghan ; Nasiri, Ali ; Kahn, Mario ; Zhang, Xian Man ; Zhang, Dongyan ; Sammalkorpi, Henna and Penttilä, Anne K. , et al. (2023) In Proceedings of the National Academy of Sciences of the United States of America 120(4).
- Contribution to journal › Article
2022
Mark Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Luukkonen, Panu K. ; Qadri, Sami ; Ahlholm, Noora ; Porthan, Kimmo ; Männistö, Ville ; Sammalkorpi, Henna ; Penttilä, Anne K. ; Hakkarainen, Antti ; Lehtimäki, Tiina E. and Gaggini, Melania , et al. (2022) In Journal of Hepatology 76(3). p.526-535
- Contribution to journal › Article
2021
Mark The PNPLA3-I148M Variant Confers an Antiatherogenic Lipid Profile in Insulin-resistant Patients
Luukkonen, Panu K. ; Qadri, Sami ; Lehtimäki, Tiina E. ; Juuti, Anne ; Sammalkorpi, Henna ; Penttilä, Anne K. ; Hakkarainen, Antti ; Orho-Melander, Marju ^LU ; Arola, Johanna and Yki-Järvinen, Hannele (2021) In The Journal of clinical endocrinology and metabolism 106(1). p.300-315
- Contribution to journal › Article
Mark Assessment of lifestyle factors helps to identify liver fibrosis due to non-alcoholic fatty liver disease in obesity
Lahelma, Mari ; Luukkonen, Panu K. ; Qadri, Sami ; Ahlholm, Noora ; Lallukka-Brück, Susanna ; Porthan, Kimmo ; Juuti, Anne ; Sammalkorpi, Henna ; Penttilä, Anne K. and Arola, Johanna , et al. (2021) In Nutrients 13(1).
- Contribution to journal › Article
2020
Mark MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans
Luukkonen, Panu K. ; Juuti, Anne ; Sammalkorpi, Henna ; Penttilä, Anne K. ; Orešič, Matej ; Hyötyläinen, Tuulia ; Arola, Johanna ; Orho-Melander, Marju ^LU and Yki-Järvinen, Hannele (2020) In Journal of Hepatology 73(3). p.725-726
- Contribution to journal › Letter
Mark Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease
Luukkonen, Panu K. ; Tukiainen, Taru ; Juuti, Anne ; Sammalkorpi, Henna ; Nidhina Haridas, P. A. ; Niemelä, Onni ; Arola, Johanna ; Orho-Melander, Marju ^LU ; Hakkarainen, Antti and Kovanen, Petri T. , et al. (2020) In JCI Insight 5(5).
- Contribution to journal › Article
Mark The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue
Qadri, Sami ; Lallukka-Brück, Susanna ; Luukkonen, Panu K. ; Zhou, You ; Gastaldelli, Amalia ; Orho-Melander, Marju ^LU ; Sammalkorpi, Henna ; Juuti, Anne ; Penttilä, Anne K. and Perttilä, Julia , et al. (2020) In Liver International 40(9). p.2128-2138
- Contribution to journal › Article
2019
Mark Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids
Luukkonen, Panu K. ; Nick, Auli ; Hölttä-Vuori, Maarit ; Thiele, Christoph ; Isokuortti, Elina ; Lallukka-Brück, Susanna ; Zhou, You ; Hakkarainen, Antti ; Lundbom, Nina and Peltonen, Markku , et al. (2019) In JCI Insight 4(16).
- Contribution to journal › Article
2018
Mark Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars
Luukkonen, Panu K. ; Ali, Ashfaq ^LU ; Orho-Melander, Marju ^LU and Yki-Järvinen, Hannele (2018) In Diabetes Care 41(8). p.1732-1739
- Contribution to journal › Article

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