Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.
(2011) In PLoS ONE 6(4).- Abstract
- The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1937116
- author
- Esguerra, Jonathan LU ; Bolmeson, Caroline LU ; Cilio, Corrado LU and Eliasson, Lena LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Islets of Langerhans/*drug effects/*metabolism, MicroRNAs/*genetics, Glucose/*pharmacology, Gene Expression Profiling, Animals, Type 2/*metabolism, Diabetes Mellitus, Polymerase Chain Reaction, Rats, Wistar
- in
- PLoS ONE
- volume
- 6
- issue
- 4
- article number
- e18613
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000289238700029
- pmid:21490936
- scopus:79954555856
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0018613
- language
- English
- LU publication?
- yes
- id
- a3eed891-e89f-4675-915e-30b5cb5db6f2 (old id 1937116)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21490936?dopt=Abstract
- date added to LUP
- 2016-04-04 09:37:46
- date last changed
- 2022-04-08 03:52:24
@article{a3eed891-e89f-4675-915e-30b5cb5db6f2, abstract = {{The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.}}, author = {{Esguerra, Jonathan and Bolmeson, Caroline and Cilio, Corrado and Eliasson, Lena}}, issn = {{1932-6203}}, keywords = {{Islets of Langerhans/*drug effects/*metabolism; MicroRNAs/*genetics; Glucose/*pharmacology; Gene Expression Profiling; Animals; Type 2/*metabolism; Diabetes Mellitus; Polymerase Chain Reaction; Rats; Wistar}}, language = {{eng}}, number = {{4}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.}}, url = {{https://lup.lub.lu.se/search/files/5375095/1961773.pdf}}, doi = {{10.1371/journal.pone.0018613}}, volume = {{6}}, year = {{2011}}, }