Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses
(2009) In Optics Express 17(13). p.10849-10863- Abstract
- We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O-2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5 x 10(-5) for oxygen and 5 x 10(-4) for water vapor, but varies between patients... (More)
- We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O-2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5 x 10(-5) for oxygen and 5 x 10(-4) for water vapor, but varies between patients due to differences in light attenuation. In addition, we discuss the use of water vapor as a reference in quantification of in situ oxygen concentration in detail. In particular, light propagation aspects are investigated by employing photon time-of-flight spectroscopy. (C) 2009 Optical Society of America (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2258750
- author
- Lewander, Märta LU ; Guan, Zuguang LU ; Svanberg, Katarina LU ; Svanberg, Sune LU and Svensson, Tomas LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Optics Express
- volume
- 17
- issue
- 13
- pages
- 10849 - 10863
- publisher
- Optical Society of America
- external identifiers
-
- pmid:19550485
- wos:000267761100046
- scopus:67649383613
- ISSN
- 1094-4087
- DOI
- 10.1364/OE.17.010849
- language
- English
- LU publication?
- yes
- id
- 785d6329-b250-4897-a4c1-5233699422b2 (old id 2258750)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19550485?dopt=Abstract
- date added to LUP
- 2016-04-04 09:08:17
- date last changed
- 2022-03-23 04:10:57
@article{785d6329-b250-4897-a4c1-5233699422b2, abstract = {{We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O-2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5 x 10(-5) for oxygen and 5 x 10(-4) for water vapor, but varies between patients due to differences in light attenuation. In addition, we discuss the use of water vapor as a reference in quantification of in situ oxygen concentration in detail. In particular, light propagation aspects are investigated by employing photon time-of-flight spectroscopy. (C) 2009 Optical Society of America}}, author = {{Lewander, Märta and Guan, Zuguang and Svanberg, Katarina and Svanberg, Sune and Svensson, Tomas}}, issn = {{1094-4087}}, language = {{eng}}, number = {{13}}, pages = {{10849--10863}}, publisher = {{Optical Society of America}}, series = {{Optics Express}}, title = {{Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses}}, url = {{https://lup.lub.lu.se/search/files/5241957/2297389.pdf}}, doi = {{10.1364/OE.17.010849}}, volume = {{17}}, year = {{2009}}, }