A Role for TLRs in Moraxella-superantigen induced polyclonal B cell activation.
(2012) In Frontiers in bioscience (Scholar edition) 4. p.1031-1043- Abstract
- A number of microorganisms are capable of binding immunoglobulins (Igs) in a manner, which excludes binding to conventional antigen binding sites. Interaction of such bacterial proteins with surface immunoglobulins leads to polyclonal activation of B-lymphocytes. A recent example is Moraxella catarrhalis that binds to B lymphocytes in an IgD-dependent manner and induces proliferation and differentiation of B lymphocytes leading to the production of unspecific Igs. The activation is mediated by Moraxella IgD binding protein (MID), which specifically binds to both soluble IgD and the IgD B cell receptor (BCR). Besides cross-linking the BCR, whole Moraxella and outer membrane vesicles (OMVs) engage Toll like receptors (TLRs) to further... (More)
- A number of microorganisms are capable of binding immunoglobulins (Igs) in a manner, which excludes binding to conventional antigen binding sites. Interaction of such bacterial proteins with surface immunoglobulins leads to polyclonal activation of B-lymphocytes. A recent example is Moraxella catarrhalis that binds to B lymphocytes in an IgD-dependent manner and induces proliferation and differentiation of B lymphocytes leading to the production of unspecific Igs. The activation is mediated by Moraxella IgD binding protein (MID), which specifically binds to both soluble IgD and the IgD B cell receptor (BCR). Besides cross-linking the BCR, whole Moraxella and outer membrane vesicles (OMVs) engage Toll like receptors (TLRs) to further increase the response. TLR activation leads to initiation of signaling pathways, which evoke a proinflammatory response against the invading microbes. Polyclonal B cell activation has in general been implicated in various phenomenons that are detrimental for the host but beneficial for pathogens, for example, autoimmune manifestations and redirection of the immune system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2273500
- author
- Singh, Kalpana ; Bayrak, Burcu LU and Riesbeck, Kristian LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Frontiers in bioscience (Scholar edition)
- volume
- 4
- pages
- 1031 - 1043
- publisher
- Frontiers in Bioscience
- external identifiers
-
- pmid:22202107
- scopus:84869387874
- ISSN
- 1945-0524
- language
- English
- LU publication?
- yes
- id
- 25b3d170-5817-4d0f-b9ed-c1521d3a56f6 (old id 2273500)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22202107?dopt=Abstract
- date added to LUP
- 2016-04-04 09:40:47
- date last changed
- 2022-03-31 07:38:51
@article{25b3d170-5817-4d0f-b9ed-c1521d3a56f6, abstract = {{A number of microorganisms are capable of binding immunoglobulins (Igs) in a manner, which excludes binding to conventional antigen binding sites. Interaction of such bacterial proteins with surface immunoglobulins leads to polyclonal activation of B-lymphocytes. A recent example is Moraxella catarrhalis that binds to B lymphocytes in an IgD-dependent manner and induces proliferation and differentiation of B lymphocytes leading to the production of unspecific Igs. The activation is mediated by Moraxella IgD binding protein (MID), which specifically binds to both soluble IgD and the IgD B cell receptor (BCR). Besides cross-linking the BCR, whole Moraxella and outer membrane vesicles (OMVs) engage Toll like receptors (TLRs) to further increase the response. TLR activation leads to initiation of signaling pathways, which evoke a proinflammatory response against the invading microbes. Polyclonal B cell activation has in general been implicated in various phenomenons that are detrimental for the host but beneficial for pathogens, for example, autoimmune manifestations and redirection of the immune system.}}, author = {{Singh, Kalpana and Bayrak, Burcu and Riesbeck, Kristian}}, issn = {{1945-0524}}, language = {{eng}}, pages = {{1031--1043}}, publisher = {{Frontiers in Bioscience}}, series = {{Frontiers in bioscience (Scholar edition)}}, title = {{A Role for TLRs in Moraxella-superantigen induced polyclonal B cell activation.}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed/22202107?dopt=Abstract}}, volume = {{4}}, year = {{2012}}, }