Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort
(2016) In British Journal of Cancer 115(4). p.480-489- Abstract
Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan-Meier method was used to correlate the analysed elements with survival.Results:The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate <15%. Specifically,... (More)
Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan-Meier method was used to correlate the analysed elements with survival.Results:The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate <15%. Specifically, tumours with irregularly shaped blood vessels, large sinusoid-like vessels, smaller and tortuous venules and arterioles and with large areas of reticulin fibres forming large, crosslinking, branching and haphazardly arranged networks were linked to the ultra-high-risk phenotype.Conclusions:We demonstrate that quantification of tumour stroma components by morphometric techniques has the potential to improve risk stratification of neuroblastoma patients.
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- author
- Tadeo, Irene ; Berbegall, Ana P. ; Castel, Victoria ; García-Miguel, Purificación ; Callaghan, Robert ; Påhlman, Sven LU ; Navarro, Samuel and Noguera, Rosa
- organization
- publishing date
- 2016-08-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Cancer
- volume
- 115
- issue
- 4
- pages
- 10 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:84978473807
- pmid:27415013
- wos:000381302700011
- ISSN
- 0007-0920
- DOI
- 10.1038/bjc.2016.210
- language
- English
- LU publication?
- yes
- id
- 0ac2e0c3-ecb0-4d3a-a42a-2656b4c8de69
- date added to LUP
- 2016-12-29 13:12:42
- date last changed
- 2024-04-19 17:11:51
@article{0ac2e0c3-ecb0-4d3a-a42a-2656b4c8de69,
abstract = {{<p>Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan-Meier method was used to correlate the analysed elements with survival.Results:The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate <15%. Specifically, tumours with irregularly shaped blood vessels, large sinusoid-like vessels, smaller and tortuous venules and arterioles and with large areas of reticulin fibres forming large, crosslinking, branching and haphazardly arranged networks were linked to the ultra-high-risk phenotype.Conclusions:We demonstrate that quantification of tumour stroma components by morphometric techniques has the potential to improve risk stratification of neuroblastoma patients.</p>}},
author = {{Tadeo, Irene and Berbegall, Ana P. and Castel, Victoria and García-Miguel, Purificación and Callaghan, Robert and Påhlman, Sven and Navarro, Samuel and Noguera, Rosa}},
issn = {{0007-0920}},
language = {{eng}},
month = {{08}},
number = {{4}},
pages = {{480--489}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort}},
url = {{http://dx.doi.org/10.1038/bjc.2016.210}},
doi = {{10.1038/bjc.2016.210}},
volume = {{115}},
year = {{2016}},
}