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- 2019
- Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies
- Sequence variation at the MTHFD1L-AKAP12 and FOPNL loci does not influence multiple myeloma survival in Sweden
- 2018
- DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and −KTS isoforms—From initial observations to recent global genomic analyses
- Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
- The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
- Target Genes of WT1 in Leukemic Cells
- 2017
-
Distinct global binding patterns of the Wilms' tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells
Ullmark, Tove LU ; Järvstråt, Linnea LU ; Sanden, Carl LU ; Montano, Giorgia LU ; Jernmark-Nilsson, Helena LU ; Lilljebjörn, Henrik LU
; Lennartsson, Andreas
LU
; Fioretos, Thoas
LU
; Drott, Kristina
LU
and Vidovic, Karina
LU
, et al.
(2017)
In Haematologica
102(2).
p.336-345
Mark
- The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo
- The transcriptional coregulator NAB2 is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells
- Direct evidence for a polygenic etiology in familial multiple myeloma
-
Identification of sequence variants influencing immunoglobulin levels
Jonsson, Stefan ; Sveinbjornsson, Gardar ; de Lapuente Portilla, Aitzkoa Lopez LU ; Swaminathan, Bhairavi LU ; Plomp, Rosina ; Dekkers, Gillian ; Ajore, Ram LU ; Ali, Mina LU ; Bentlage, Arthur E H and Elmér, Evelina LU
, et al.
(2017)
In Nature Genetics
49(8).
p.1182-1191
Mark
- Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells
- 2016
- The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein.
- Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
- Global binding pattern of the Wilms' tumor gene 1 (WT1) +17AA -KTS isoform in leukemic cells
- 2015
-
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
Swaminathan, Bhairavi LU ; Thorleifsson, Guðmar ; Jöud, Magnus LU
; Ali, Mina
LU
; Johnsson, Ellinor
LU
; Ajore, Ram
LU
; Sulem, Patrick
; Halvarsson, Britt-Marie
LU
; Eyjolfsson, Guðmundur
and Haraldsdottir, Vilhelmina
, et al.
(2015)
In Nature Communications
6.
p.1-8
Mark
- Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.
- WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene.
- Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo.
- The DEK oncoprotein is upregulated by multiple leukemia-associated fusion genes.
- The DEK oncoprotein and its emerging roles in gene regulation.
- 2014
- The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.
- Robust isolation of malignant plasma cells in multiple myeloma.
- 2013
-
The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.
Kumar, Parveen LU ; Sharoyko, Vladimir LU ; Spégel, Peter LU ; Gullberg, Urban LU ; Mulder, Hindrik LU
; Olsson, Inge
LU
and Ajore, Ram
LU
(2013)
In PLoS ONE
8(7).
Mark
- Lentivirus-Induced Dendritic Cells for Immunization Against High-Risk WT1(+) Acute Myeloid Leukemia
- Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR
- Ultranet: efficient solver for the sparse inverse covariance selection problem in gene network modeling.
- Leukemia associated mutant Wilms' tumor gene 1 protein promotes expansion of human hematopoietic progenitor cells.
- Role of WT1-ZNF224 interaction in the expression of the tumor suppressor interferon regulatory factor 8 in leukemia cells
- 2012
- The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells
- Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
- The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G.
- 2010
- Wilms' tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells.
- The human IFN-inducible p53 target gene TRIM22 colocalizes with the centrosome independently of cell cycle phase.
- The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells
- 2008
-
Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation.
Håkansson, Petra LU ; Nilsson, Björn LU ; Andersson, Anna LU
; Lassen, Carin
LU
; Gullberg, Urban
LU
and Fioretos, Thoas
LU
(2008)
In Genes, Chromosomes and Cancer
47(4).
p.267-275
Mark
- The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias
- Identification of a novel and myeloid specific role of the leukemia-associated fusion protein DEK-NUP214 leading to increased protein synthesis.
- 2007
- Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.
- Regulation of the interferon-inducible p53 target gene TRIM22 (Staf50) in human T lymphocyte activation
-
The Wilms' tumor gene 1 (WT1) induces expression of the N-myc downstream regulated gene 2 (NDRG2)
Svensson, Emelie LU ; Vidovic, Karina LU ; Olofsson, Tor LU ; Vallon-Christersson, Johan LU
; Borg, Åke
LU
and Gullberg, Urban
LU
(2007)
In DNA and Cell Biology
26(8).
p.589-597
Mark
- Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells
- Cellbiologi
- 2006
- All-trans retinoic acid-induced expression of bactericidal/permeability-increasing protein (BPI) in human myeloid cells correlates to binding of C/EBP{beta} and C/EBP{varepsilon} to the BPI promoter.
- Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein
- The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK
- 2005
- DNA-binding dependent and independent functions of WT1 protein during human hematopoiesis.
- A murine antibacterial orthologue to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow.
- The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.
- Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model
- 2004
-
Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells.
Obad, Susanna LU ; Brunnström, Hans ; Vallon-Christersson, Johan LU
; Borg, Åke
LU
; Drott, Kristina
LU
and Gullberg, Urban
LU
(2004)
In Oncogene
23(23).
p.4050-4059
Mark
- Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays.
-
The - 564 A/G polymorphism in the promoter region of the proteinase 3 gene associated with Wegener's granulomatosis does not increase the promoter activity.
Pieters, Katrien LU ; Pettersson, Åsa LU ; Gullberg, Urban LU and Hellmark, Thomas LU
(2004)
In Clinical and Experimental Immunology
138(2).
p.266-270
Mark
- Establishment and phenotypic characterization of human U937 cells with inducible P210 BCR/ABL expression reveals upregulation of CEACAM1 (CD66a).
- 2003
- AML-1, PU.1, and Sp3 regulate expression of human bactericidal/permeability-increasing protein.
- A burning existence
- 2002
- Sorting of neutrophil-specific granule protein human cathelicidin, hCAP-18, when constitutively expressed in myeloid cells.
- Functional dissociation between proforms and mature forms of proteinase 3, azurocidin, and granzyme B in regulation of granulopoiesis.
- Sorting for storage in myeloid cells of nonmyeloid proteins and chimeras with the propeptide of myeloperoxidase precursor.
- 2001
- The human brm protein is cleaved during apoptosis: the role of cathepsin G
- Forced expression of the cyclin-dependent kinase inhibitor p16(INK4A) in leukemic U-937 cells reveals dissociation between cell cycle and differentiation
- Forced expression of the Wilms tumor 1 (WT1) gene inhibits proliferation of human hematopoietic CD34(+) progenitor cells
- 1998
- Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program
- p53-dependent and -independent differentiation of leukemic U-937 cells: relationship to cell cycle control
- 1997
-
Characterization of the processing and granular targeting of human proteinase 3 after transfection to the rat RBL or the murine 32D leukemic cell lines
Garwicz, Daniel LU ; Lindmark, Anders LU ; Hellmark, Thomas LU
; Gladh, Mathias
; Jögi, Jonas
LU
and Gullberg, Urban
LU
(1997)
In Journal of Leukocyte Biology
61(1).
p.113-123
Mark
- Altered expression of the retinoblastoma tumor-suppressor gene in leukemic cell lines inhibits induction of differentiation but not G1-accumulation
- 1996
- Expression of the p53 tumor suppressor gene induces differentiation and promotes induction of differentiation by 1,25-dihydroxycholecalciferol in leukemic U-937 cells
- 1995
- Metalloproteases and serineproteases are involved in the cleavage of the two tumour necrosis factor (TNF) receptors to soluble forms in the myeloid cell lines U-937 and THP-1
- TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor
- 1994
- The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability increasing protein
- 1993
- Phorbol ester-induced degranulation in adherent human eosinophil granulocytes is dependent on CD11/CD18 leukocyte integrins
- 1986
- The biosynthesis of neutrophil and eosinophil granule proteins
- The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity