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/Pg 19 0 R
>>
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488 0 obj
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/K [5]
/Pg 19 0 R
>>
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489 0 obj
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/K [6]
/Pg 19 0 R
>>
endobj
490 0 obj
<<
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>>
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491 0 obj
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/K [8]
/Pg 19 0 R
>>
endobj
492 0 obj
<<
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/K [9]
/Pg 19 0 R
>>
endobj
493 0 obj
<<
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/K [10]
/Pg 19 0 R
>>
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494 0 obj
<<
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/K [11]
/Pg 19 0 R
>>
endobj
495 0 obj
<<
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/K [12]
/Pg 19 0 R
>>
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496 0 obj
<<
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/K [13]
/Pg 19 0 R
>>
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497 0 obj
<<
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/K [14]
/Pg 19 0 R
>>
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498 0 obj
<<
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/K [15]
/Pg 19 0 R
>>
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499 0 obj
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/K [16]
/Pg 19 0 R
>>
endobj
500 0 obj
<<
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/K [17]
/Pg 19 0 R
>>
endobj
501 0 obj
<<
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/ActualText (. While )
/K [18]
/Pg 19 0 R
>>
endobj
502 0 obj
<<
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/ActualText (the )
/K [19]
/Pg 19 0 R
>>
endobj
503 0 obj
<<
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/ActualText (C3 domain creates )
/K [20]
/Pg 19 0 R
>>
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504 0 obj
<<
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/K [21]
/Pg 19 0 R
>>
endobj
505 0 obj
<<
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/K [22]
/Pg 19 0 R
>>
endobj
506 0 obj
<<
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/ActualText ( )
/K [23]
/Pg 19 0 R
>>
endobj
507 0 obj
<<
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/K [24]
/Pg 19 0 R
>>
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508 0 obj
<<
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/ActualText (binding site. )
/K [25]
/Pg 19 0 R
>>
endobj
509 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (Novel PKC isoforms)
/K [26]
/Pg 19 0 R
>>
endobj
510 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [27]
/Pg 19 0 R
>>
endobj
511 0 obj
<<
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/ActualText (include)
/K [28]
/Pg 19 0 R
>>
endobj
512 0 obj
<<
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/ActualText ( )
/K [29]
/Pg 19 0 R
>>
endobj
513 0 obj
<<
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/ActualText (PKC)
/K [30]
/Pg 19 0 R
>>
endobj
514 0 obj
<<
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/ActualText
/K [31]
/Pg 19 0 R
>>
endobj
515 0 obj
<<
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/ActualText (, PKC)
/K [32]
/Pg 19 0 R
>>
endobj
516 0 obj
<<
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/Type /StructElem
/ActualText
/K [33]
/Pg 19 0 R
>>
endobj
517 0 obj
<<
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/ActualText (, PKC)
/K [34]
/Pg 19 0 R
>>
endobj
518 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText
/K [35]
/Pg 19 0 R
>>
endobj
519 0 obj
<<
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/ActualText ( )
/K [36]
/Pg 19 0 R
>>
endobj
520 0 obj
<<
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/ActualText (and PKC)
/K [37]
/Pg 19 0 R
>>
endobj
521 0 obj
<<
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/ActualText
/K [38]
/Pg 19 0 R
>>
endobj
522 0 obj
<<
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/ActualText (. )
/K [39]
/Pg 19 0 R
>>
endobj
523 0 obj
<<
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/ActualText (These PKC isoforms )
/K [40]
/Pg 19 0 R
>>
endobj
524 0 obj
<<
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/ActualText (also have C1)
/K [41]
/Pg 19 0 R
>>
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525 0 obj
<<
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/ActualText (A and C1B)
/K [42]
/Pg 19 0 R
>>
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526 0 obj
<<
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/ActualText ( )
/K [43]
/Pg 19 0 R
>>
endobj
527 0 obj
<<
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/ActualText (domains)
/K [44]
/Pg 19 0 R
>>
endobj
528 0 obj
<<
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/ActualText ( )
/K [45]
/Pg 19 0 R
>>
endobj
529 0 obj
<<
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/ActualText (while )
/K [46]
/Pg 19 0 R
>>
endobj
530 0 obj
<<
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/ActualText (they )
/K [47]
/Pg 19 0 R
>>
endobj
531 0 obj
<<
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/ActualText (lack a functional C2 domain)
/K [48]
/Pg 19 0 R
>>
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532 0 obj
<<
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/ActualText (. They are thus)
/K [49]
/Pg 19 0 R
>>
endobj
533 0 obj
<<
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/ActualText ( )
/K [50]
/Pg 19 0 R
>>
endobj
534 0 obj
<<
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/ActualText (r)
/K [51]
/Pg 19 0 R
>>
endobj
535 0 obj
<<
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/ActualText (egulat)
/K [52]
/Pg 19 0 R
>>
endobj
536 0 obj
<<
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/ActualText (ed)
/K [53]
/Pg 19 0 R
>>
endobj
537 0 obj
<<
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/ActualText ( )
/K [54]
/Pg 19 0 R
>>
endobj
538 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (by )
/K [55]
/Pg 19 0 R
>>
endobj
539 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (phospholipids)
/K [56]
/Pg 19 0 R
>>
endobj
540 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [57]
/Pg 19 0 R
>>
endobj
541 0 obj
<<
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/ActualText (and DAG)
/K [58]
/Pg 19 0 R
>>
endobj
542 0 obj
<<
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/ActualText ( )
/K [59]
/Pg 19 0 R
>>
endobj
543 0 obj
<<
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/ActualText (but not by calcium)
/K [60]
/Pg 19 0 R
>>
endobj
544 0 obj
<<
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/ActualText ( )
/K [61]
/Pg 19 0 R
>>
endobj
545 0 obj
<<
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/Type /StructElem
/ActualText (ions)
/K [62]
/Pg 19 0 R
>>
endobj
546 0 obj
<<
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/Type /StructElem
/ActualText (.)
/K [63]
/Pg 19 0 R
>>
endobj
547 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [64]
/Pg 19 0 R
>>
endobj
548 0 obj
<<
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/ActualText (Instead of )
/K [65]
/Pg 19 0 R
>>
endobj
549 0 obj
<<
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/ActualText (a )
/K [66]
/Pg 19 0 R
>>
endobj
550 0 obj
<<
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/ActualText (functional C2 )
/K [67]
/Pg 19 0 R
>>
endobj
551 0 obj
<<
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/ActualText (domain)
/K [68]
/Pg 19 0 R
>>
endobj
552 0 obj
<<
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/ActualText (, the )
/K [69]
/Pg 19 0 R
>>
endobj
553 0 obj
<<
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/ActualText (novel PKC isoforms contain a n)
/K [70]
/Pg 19 0 R
>>
endobj
554 0 obj
<<
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/ActualText (ovel C2 domain that )
/K [71]
/Pg 19 0 R
>>
endobj
555 0 obj
<<
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/ActualText (has)
/K [72]
/Pg 19 0 R
>>
endobj
556 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [73]
/Pg 19 0 R
>>
endobj
557 0 obj
<<
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/ActualText (important roles in cell )
/K [74]
/Pg 19 0 R
>>
endobj
558 0 obj
<<
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/ActualText (signaling )
/K [75]
/Pg 19 0 R
>>
endobj
559 0 obj
<<
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/Type /StructElem
/ActualText (despite)
/K [76]
/Pg 19 0 R
>>
endobj
560 0 obj
<<
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/ActualText ( )
/K [77]
/Pg 19 0 R
>>
endobj
561 0 obj
<<
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/Type /StructElem
/ActualText (lack)
/K [78]
/Pg 19 0 R
>>
endobj
562 0 obj
<<
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/Type /StructElem
/ActualText (ing)
/K [79]
/Pg 19 0 R
>>
endobj
563 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [80]
/Pg 19 0 R
>>
endobj
564 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (affinity )
/K [81]
/Pg 19 0 R
>>
endobj
565 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (for)
/K [82]
/Pg 19 0 R
>>
endobj
566 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [83]
/Pg 19 0 R
>>
endobj
567 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (calcium ion)
/K [84]
/Pg 19 0 R
>>
endobj
568 0 obj
<<
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/ActualText (s)
/K [85]
/Pg 19 0 R
>>
endobj
569 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [86]
/Pg 19 0 R
>>
endobj
570 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\()
/K [87]
/Pg 19 0 R
>>
endobj
571 0 obj
<<
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/Type /StructElem
/ActualText (9)
/K [88]
/Pg 19 0 R
>>
endobj
572 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\))
/K [89]
/Pg 19 0 R
>>
endobj
573 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (. )
/K [90]
/Pg 19 0 R
>>
endobj
574 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (Atypical PKC isoforms, PKC)
/K [91]
/Pg 19 0 R
>>
endobj
575 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText
/K [92]
/Pg 19 0 R
>>
endobj
576 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [93]
/Pg 19 0 R
>>
endobj
577 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (and PKC)
/K [94]
/Pg 19 0 R
>>
endobj
578 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText
/K [95]
/Pg 19 0 R
>>
endobj
579 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (,)
/K [96]
/Pg 19 0 R
>>
endobj
580 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [97]
/Pg 19 0 R
>>
endobj
581 0 obj
<<
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/Type /StructElem
/ActualText (completely lack C2 domain and)
/K [98]
/Pg 19 0 R
>>
endobj
582 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [99]
/Pg 19 0 R
>>
endobj
583 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (one)
/K [100]
/Pg 19 0 R
>>
endobj
584 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [101]
/Pg 19 0 R
>>
endobj
585 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (C1 domain, )
/K [102]
/Pg 19 0 R
>>
endobj
586 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (and are therefore)
/K [103]
/Pg 19 0 R
>>
endobj
587 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [104]
/Pg 19 0 R
>>
endobj
588 0 obj
<<
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/Type /StructElem
/ActualText (independent )
/K [105]
/Pg 19 0 R
>>
endobj
589 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (of)
/K [106]
/Pg 19 0 R
>>
endobj
590 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [107]
/Pg 19 0 R
>>
endobj
591 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (DAG and )
/K [108]
/Pg 19 0 R
>>
endobj
592 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (calcium)
/K [109]
/Pg 19 0 R
>>
endobj
593 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [110]
/Pg 19 0 R
>>
endobj
594 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (for their )
/K [111]
/Pg 19 0 R
>>
endobj
595 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (regulation)
/K [112]
/Pg 19 0 R
>>
endobj
596 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (, but can be regulated by )
/K [113]
/Pg 19 0 R
>>
endobj
597 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (phospholipids)
/K [114]
/Pg 19 0 R
>>
endobj
598 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [115]
/Pg 19 0 R
>>
endobj
599 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [116]
/Pg 19 0 R
>>
endobj
600 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (Atypical PKC isoforms )
/K [117]
/Pg 19 0 R
>>
endobj
601 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (contain a PB1 domain that plays a role in protein dimerization. )
/K [118]
/Pg 19 0 R
>>
endobj
602 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (B)
/K [119]
/Pg 19 0 R
>>
endobj
603 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (inding of )
/K [120]
/Pg 19 0 R
>>
endobj
604 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (DAG and calcium)
/K [121]
/Pg 19 0 R
>>
endobj
605 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [122]
/Pg 19 0 R
>>
endobj
606 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (to )
/K [123]
/Pg 19 0 R
>>
endobj
607 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (the regulatory domain help)
/K [124]
/Pg 19 0 R
>>
endobj
608 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (s)
/K [125]
/Pg 19 0 R
>>
endobj
609 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [126]
/Pg 19 0 R
>>
endobj
610 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (specific PKC isoforms to localize to)
/K [127]
/Pg 19 0 R
>>
endobj
611 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [128]
/Pg 19 0 R
>>
endobj
612 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (the)
/K [129]
/Pg 19 0 R
>>
endobj
613 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [130]
/Pg 19 0 R
>>
endobj
614 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (specific s)
/K [131]
/Pg 19 0 R
>>
endobj
615 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (ubcellular )
/K [132]
/Pg 19 0 R
>>
endobj
616 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (compartments.)
/K [133]
/Pg 19 0 R
>>
endobj
617 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [134]
/Pg 19 0 R
>>
endobj
618 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (A common feature of a)
/K [135]
/Pg 19 0 R
>>
endobj
619 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (ll PKC isoforms )
/K [136]
/Pg 19 0 R
>>
endobj
620 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (is )
/K [137]
/Pg 19 0 R
>>
endobj
621 0 obj
<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText (the )
/K [138]
/Pg 19 0 R
>>
endobj
622 0 obj
<<
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/Type /StructElem
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/K [139]
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>>
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<<
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/K [140]
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>>
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<<
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/S /Span
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>>
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<<
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>>
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>>
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/S /Span
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/K [147]
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>>
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<<
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/K [148]
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<<
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/K [149]
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>>
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/K [151]
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<<
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/K [154]
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/K [155]
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>>
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<<
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/K [156]
/Pg 19 0 R
>>
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<<
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/S /Span
/Type /StructElem
/ActualText (. Binding of factors to the regulatory domain causes necessary )
/K [157]
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>>
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<<
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/Type /StructElem
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/K [158]
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>>
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<<
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/S /Span
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/K [159]
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>>
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<<
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/S /Span
/Type /StructElem
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/K [160]
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>>
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/K [161]
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/K [162]
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>>
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/K [164]
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endobj
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<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [165]
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>>
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<<
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/S /Span
/Type /StructElem
/ActualText (substrate)
/K [166]
/Pg 19 0 R
>>
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<<
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/S /Span
/Type /StructElem
/ActualText (s)
/K [167]
/Pg 19 0 R
>>
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<<
/P 3578 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [168]
/Pg 19 0 R
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<<
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/S /Span
/Type /StructElem
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/K [169]
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/Type /StructElem
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/K [171]
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<<
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/S /Span
/Type /StructElem
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/Type /StructElem
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/K [173]
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<<
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/K [174]
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/Type /StructElem
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<<
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/Type /StructElem
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>>
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>>
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/K [182]
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/S /Span
/Type /StructElem
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<<
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/K [184]
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/K [185]
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>>
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<<
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/Type /StructElem
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/K [186]
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<<
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/K [187]
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/K [189]
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/K [190]
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/Type /StructElem
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<<
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/S /Span
/Type /StructElem
/ActualText ( )
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/K [193]
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<<
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/Type /StructElem
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/K [195]
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>>
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/K [199]
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>>
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<<
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/Type /StructElem
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/K [200]
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>>
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<<
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/S /Span
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/ActualText (\()
/K [201]
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>>
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<<
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/S /Span
/Type /StructElem
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/K [202]
/Pg 19 0 R
>>
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<<
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/K [203]
/Pg 19 0 R
>>
endobj
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<<
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/S /Span
/Type /StructElem
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/K [204]
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/K [205]
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<<
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<<
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<<
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/K [208]
/Pg 19 0 R
>>
endobj
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<<
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/S /Span
/Type /StructElem
/ActualText (PKC isoforms are expressed and retained in )
/K [209]
/Pg 19 0 R
>>
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693 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (the )
/K [210]
/Pg 19 0 R
>>
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694 0 obj
<<
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/Type /StructElem
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/K [211]
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>>
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<<
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/K [212]
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>>
endobj
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<<
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/Type /StructElem
/ActualText ( )
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>>
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<<
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/K [214]
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>>
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<<
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/ActualText ( )
/K [215]
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>>
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<<
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/K [216]
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>>
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/K [217]
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<<
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>>
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<<
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>>
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<<
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/K [220]
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<<
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/Type /StructElem
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/Pg 19 0 R
>>
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<<
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/Type /StructElem
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/K [222]
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>>
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>>
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/K [224]
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>>
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<<
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/K [226]
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>>
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/K [227]
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>>
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/Type /StructElem
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/K [228]
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>>
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<<
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/K [229]
/Pg 19 0 R
>>
endobj
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<<
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/K [230]
/Pg 19 0 R
>>
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<<
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/K [3878 0 R 499 0 R]
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>>
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>>
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>>
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/Pg 19 0 R
>>
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<<
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/K [0]
/Pg 20 0 R
>>
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/ActualText (\()
/K [1]
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>>
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/K [2]
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>>
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/K [4]
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>>
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/K [5]
/Pg 20 0 R
>>
endobj
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<<
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/Type /StructElem
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/K [6]
/Pg 20 0 R
>>
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725 0 obj
<<
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/K [7]
/Pg 20 0 R
>>
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/K [8]
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>>
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<<
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/K [9]
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>>
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<<
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/K [10]
/Pg 20 0 R
>>
endobj
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<<
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/K [11]
/Pg 20 0 R
>>
endobj
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<<
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/K [12]
/Pg 20 0 R
>>
endobj
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<<
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/Type /StructElem
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/K [13]
/Pg 20 0 R
>>
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<<
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/S /Span
/Type /StructElem
/ActualText (\()
/K [14]
/Pg 20 0 R
>>
endobj
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<<
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/K [15]
/Pg 20 0 R
>>
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<<
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/S /Span
/Type /StructElem
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/K [16]
/Pg 20 0 R
>>
endobj
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<<
/P 3582 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [17]
/Pg 20 0 R
>>
endobj
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<<
/P 3582 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [18]
/Pg 20 0 R
>>
endobj
737 0 obj
<<
/P 3582 0 R
/S /Span
/Type /StructElem
/ActualText (M)
/K [19]
/Pg 20 0 R
>>
endobj
738 0 obj
<<
/P 3582 0 R
/S /Span
/Type /StructElem
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/K [20]
/Pg 20 0 R
>>
endobj
739 0 obj
<<
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/Type /StructElem
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/K [21]
/Pg 20 0 R
>>
endobj
740 0 obj
<<
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/Type /StructElem
/ActualText (downstream signaling)
/K [22]
/Pg 20 0 R
>>
endobj
741 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [23]
/Pg 20 0 R
>>
endobj
742 0 obj
<<
/P 3582 0 R
/S /Span
/Type /StructElem
/ActualText (pathways. )
/K [24]
/Pg 20 0 R
>>
endobj
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<<
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/S /Span
/Type /StructElem
/ActualText (Although )
/K [25]
/Pg 20 0 R
>>
endobj
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<<
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/Type /StructElem
/ActualText (the )
/K [26]
/Pg 20 0 R
>>
endobj
745 0 obj
<<
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/Type /StructElem
/ActualText (DAG ana)
/K [27]
/Pg 20 0 R
>>
endobj
746 0 obj
<<
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/S /Span
/Type /StructElem
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/K [28]
/Pg 20 0 R
>>
endobj
747 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (potent tumor promoter, )
/K [29]
/Pg 20 0 R
>>
endobj
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<<
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/S /Span
/Type /StructElem
/ActualText (a)
/K [30]
/Pg 20 0 R
>>
endobj
749 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [31]
/Pg 20 0 R
>>
endobj
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<<
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/K [32]
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>>
endobj
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<<
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/Type /StructElem
/ActualText (-)
/K [33]
/Pg 20 0 R
>>
endobj
752 0 obj
<<
/P 3582 0 R
/S /Span
/Type /StructElem
/ActualText (cyclic lactone bryostatin)
/K [34]
/Pg 20 0 R
>>
endobj
753 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [35]
/Pg 20 0 R
>>
endobj
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<<
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/K [36]
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>>
endobj
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<<
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<<
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/Type /StructElem
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/K [38]
/Pg 20 0 R
>>
endobj
757 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (a)
/K [39]
/Pg 20 0 R
>>
endobj
758 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [40]
/Pg 20 0 R
>>
endobj
759 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (mimic )
/K [41]
/Pg 20 0 R
>>
endobj
760 0 obj
<<
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/S /Span
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/ActualText (of)
/K [42]
/Pg 20 0 R
>>
endobj
761 0 obj
<<
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/K [43]
/Pg 20 0 R
>>
endobj
762 0 obj
<<
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/Type /StructElem
/ActualText (TPA)
/K [44]
/Pg 20 0 R
>>
endobj
763 0 obj
<<
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/ActualText (\))
/K [45]
/Pg 20 0 R
>>
endobj
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<<
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/K [46]
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>>
endobj
765 0 obj
<<
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/K [47]
/Pg 20 0 R
>>
endobj
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<<
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/K [48]
/Pg 20 0 R
>>
endobj
767 0 obj
<<
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/ActualText (an activate PKC )
/K [49]
/Pg 20 0 R
>>
endobj
768 0 obj
<<
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/K [50]
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>>
endobj
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/K [51]
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>>
endobj
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/K [52]
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>>
endobj
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<<
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/ActualText ( )
/K [53]
/Pg 20 0 R
>>
endobj
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<<
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/Type /StructElem
/ActualText (but)
/K [54]
/Pg 20 0 R
>>
endobj
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<<
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/ActualText ( )
/K [55]
/Pg 20 0 R
>>
endobj
774 0 obj
<<
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/ActualText (does not induce differentiation of HL)
/K [56]
/Pg 20 0 R
>>
endobj
775 0 obj
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/K [57]
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>>
endobj
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/K [58]
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>>
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<<
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/K [59]
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>>
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/K [60]
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>>
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/K [61]
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>>
endobj
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<<
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/Type /StructElem
/ActualText ( )
/K [62]
/Pg 20 0 R
>>
endobj
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<<
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/K [63]
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>>
endobj
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<<
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/K [64]
/Pg 20 0 R
>>
endobj
783 0 obj
<<
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/ActualText (complete tumor promoter)
/K [65]
/Pg 20 0 R
>>
endobj
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<<
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/ActualText ( )
/K [66]
/Pg 20 0 R
>>
endobj
785 0 obj
<<
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/ActualText (\()
/K [67]
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>>
endobj
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<<
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/K [68]
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>>
endobj
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<<
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/K [69]
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>>
endobj
788 0 obj
<<
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/ActualText (.)
/K [70]
/Pg 20 0 R
>>
endobj
789 0 obj
<<
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/ActualText ( )
/K [71]
/Pg 20 0 R
>>
endobj
790 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (Thus activation of PKC might have differential function)
/K [72]
/Pg 20 0 R
>>
endobj
791 0 obj
<<
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/S /Span
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/ActualText (s)
/K [73]
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>>
endobj
792 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [74]
/Pg 20 0 R
>>
endobj
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<<
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/K [75]
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>>
endobj
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<<
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/K [76]
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>>
endobj
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<<
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/K [77]
/Pg 20 0 R
>>
endobj
796 0 obj
<<
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/ActualText (molecules.)
/K [78]
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>>
endobj
797 0 obj
<<
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/ActualText ( )
/K [79]
/Pg 20 0 R
>>
endobj
798 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (Differential subcellular localization might also play a role )
/K [80]
/Pg 20 0 R
>>
endobj
799 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (in this proce)
/K [81]
/Pg 20 0 R
>>
endobj
800 0 obj
<<
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/ActualText (ss. )
/K [82]
/Pg 20 0 R
>>
endobj
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<<
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/ActualText (The s)
/K [83]
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>>
endobj
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<<
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/ActualText (ame factor)
/K [84]
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>>
endobj
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<<
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/ActualText (s)
/K [85]
/Pg 20 0 R
>>
endobj
804 0 obj
<<
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/ActualText ( )
/K [86]
/Pg 20 0 R
>>
endobj
805 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (can direct different PKC isoforms to the different cellular )
/K [87]
/Pg 20 0 R
>>
endobj
806 0 obj
<<
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/S /Span
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/ActualText (compartments. )
/K [88]
/Pg 20 0 R
>>
endobj
807 0 obj
<<
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/ActualText (Bryostatin)
/K [89]
/Pg 20 0 R
>>
endobj
808 0 obj
<<
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/ActualText ( )
/K [90]
/Pg 20 0 R
>>
endobj
809 0 obj
<<
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/ActualText (1)
/K [91]
/Pg 20 0 R
>>
endobj
810 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [92]
/Pg 20 0 R
>>
endobj
811 0 obj
<<
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/ActualText (treatment leads to )
/K [93]
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>>
endobj
812 0 obj
<<
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/ActualText (translocat)
/K [94]
/Pg 20 0 R
>>
endobj
813 0 obj
<<
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/ActualText (ion of)
/K [95]
/Pg 20 0 R
>>
endobj
814 0 obj
<<
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/ActualText ( )
/K [96]
/Pg 20 0 R
>>
endobj
815 0 obj
<<
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/ActualText
/K [97]
/Pg 20 0 R
>>
endobj
816 0 obj
<<
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/K [98]
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>>
endobj
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<<
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/ActualText (cytosol to)
/K [99]
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>>
endobj
818 0 obj
<<
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/ActualText ( )
/K [100]
/Pg 20 0 R
>>
endobj
819 0 obj
<<
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/Type /StructElem
/ActualText (the)
/K [101]
/Pg 20 0 R
>>
endobj
820 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [102]
/Pg 20 0 R
>>
endobj
821 0 obj
<<
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/ActualText (plasma membrane )
/K [103]
/Pg 20 0 R
>>
endobj
822 0 obj
<<
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/ActualText (while it leads to translocation of )
/K [104]
/Pg 20 0 R
>>
endobj
823 0 obj
<<
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/ActualText
/K [105]
/Pg 20 0 R
>>
endobj
824 0 obj
<<
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/ActualText (II)
/K [106]
/Pg 20 0 R
>>
endobj
825 0 obj
<<
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/ActualText ( )
/K [107]
/Pg 20 0 R
>>
endobj
826 0 obj
<<
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/ActualText (to)
/K [108]
/Pg 20 0 R
>>
endobj
827 0 obj
<<
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/ActualText ( )
/K [109]
/Pg 20 0 R
>>
endobj
828 0 obj
<<
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/ActualText (the)
/K [110]
/Pg 20 0 R
>>
endobj
829 0 obj
<<
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/ActualText ( )
/K [111]
/Pg 20 0 R
>>
endobj
830 0 obj
<<
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/ActualText (plasma membrane )
/K [112]
/Pg 20 0 R
>>
endobj
831 0 obj
<<
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/ActualText (as)
/K [113]
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>>
endobj
832 0 obj
<<
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/ActualText ( )
/K [114]
/Pg 20 0 R
>>
endobj
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<<
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/ActualText (well as)
/K [115]
/Pg 20 0 R
>>
endobj
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<<
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/ActualText ( )
/K [116]
/Pg 20 0 R
>>
endobj
835 0 obj
<<
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/ActualText (to)
/K [117]
/Pg 20 0 R
>>
endobj
836 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [118]
/Pg 20 0 R
>>
endobj
837 0 obj
<<
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/Type /StructElem
/ActualText (the)
/K [119]
/Pg 20 0 R
>>
endobj
838 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [120]
/Pg 20 0 R
>>
endobj
839 0 obj
<<
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/ActualText (nuclear membrane in )
/K [121]
/Pg 20 0 R
>>
endobj
840 0 obj
<<
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/ActualText (the )
/K [122]
/Pg 20 0 R
>>
endobj
841 0 obj
<<
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/ActualText (HL60 cell line)
/K [123]
/Pg 20 0 R
>>
endobj
842 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [124]
/Pg 20 0 R
>>
endobj
843 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\()
/K [125]
/Pg 20 0 R
>>
endobj
844 0 obj
<<
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/Type /StructElem
/ActualText (12)
/K [126]
/Pg 20 0 R
>>
endobj
845 0 obj
<<
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/ActualText (\))
/K [127]
/Pg 20 0 R
>>
endobj
846 0 obj
<<
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/Type /StructElem
/ActualText (. )
/K [128]
/Pg 20 0 R
>>
endobj
847 0 obj
<<
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/Type /StructElem
/ActualText
/K [129]
/Pg 20 0 R
>>
endobj
848 0 obj
<<
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/ActualText (-)
/K [130]
/Pg 20 0 R
>>
endobj
849 0 obj
<<
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/Type /StructElem
/ActualText (phorbol 12, 13)
/K [131]
/Pg 20 0 R
>>
endobj
850 0 obj
<<
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/ActualText (-)
/K [132]
/Pg 20 0 R
>>
endobj
851 0 obj
<<
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/ActualText (dibutyrate )
/K [133]
/Pg 20 0 R
>>
endobj
852 0 obj
<<
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/ActualText (treatment )
/K [134]
/Pg 20 0 R
>>
endobj
853 0 obj
<<
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/ActualText (induce)
/K [135]
/Pg 20 0 R
>>
endobj
854 0 obj
<<
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/ActualText (s)
/K [136]
/Pg 20 0 R
>>
endobj
855 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [137]
/Pg 20 0 R
>>
endobj
856 0 obj
<<
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/Type /StructElem
/ActualText
/K [138]
/Pg 20 0 R
>>
endobj
857 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [139]
/Pg 20 0 R
>>
endobj
858 0 obj
<<
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/ActualText (to the pl)
/K [140]
/Pg 20 0 R
>>
endobj
859 0 obj
<<
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/ActualText (asma membrane)
/K [141]
/Pg 20 0 R
>>
endobj
860 0 obj
<<
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/Type /StructElem
/ActualText (, but only partial )
/K [142]
/Pg 20 0 R
>>
endobj
861 0 obj
<<
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/Type /StructElem
/ActualText
/K [143]
/Pg 20 0 R
>>
endobj
862 0 obj
<<
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/Type /StructElem
/ActualText (II)
/K [144]
/Pg 20 0 R
>>
endobj
863 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [145]
/Pg 20 0 R
>>
endobj
864 0 obj
<<
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/Type /StructElem
/ActualText (to the same cellular compartment)
/K [146]
/Pg 20 0 R
>>
endobj
865 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (.)
/K [147]
/Pg 20 0 R
>>
endobj
866 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [148]
/Pg 20 0 R
>>
endobj
867 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (Besides their translocation to the cell )
/K [149]
/Pg 20 0 R
>>
endobj
868 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (membrane, PKC isoforms)
/K [150]
/Pg 20 0 R
>>
endobj
869 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [151]
/Pg 20 0 R
>>
endobj
870 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (have )
/K [152]
/Pg 20 0 R
>>
endobj
871 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (also )
/K [153]
/Pg 20 0 R
>>
endobj
872 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (been)
/K [154]
/Pg 20 0 R
>>
endobj
873 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [155]
/Pg 20 0 R
>>
endobj
874 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (shown)
/K [156]
/Pg 20 0 R
>>
endobj
875 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [157]
/Pg 20 0 R
>>
endobj
876 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (to)
/K [158]
/Pg 20 0 R
>>
endobj
877 0 obj
<<
/P 3582 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [159]
/Pg 20 0 R
>>
endobj
878 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (be)
/K [160]
/Pg 20 0 R
>>
endobj
879 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [161]
/Pg 20 0 R
>>
endobj
880 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (associate)
/K [162]
/Pg 20 0 R
>>
endobj
881 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (d)
/K [163]
/Pg 20 0 R
>>
endobj
882 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [164]
/Pg 20 0 R
>>
endobj
883 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (with other intracellular )
/K [165]
/Pg 20 0 R
>>
endobj
884 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (compartments. Many of them reside )
/K [166]
/Pg 20 0 R
>>
endobj
885 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (at)
/K [167]
/Pg 20 0 R
>>
endobj
886 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [168]
/Pg 20 0 R
>>
endobj
887 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (the)
/K [169]
/Pg 20 0 R
>>
endobj
888 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [170]
/Pg 20 0 R
>>
endobj
889 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (nuclear membrane or anchor with Golgi and )
/K [171]
/Pg 20 0 R
>>
endobj
890 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (mitochondrial membranes )
/K [172]
/Pg 20 0 R
>>
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/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [72]
/Pg 21 0 R
>>
endobj
1026 0 obj
<<
/P 1153 0 R
/S /Span
/Type /StructElem
/ActualText (21)
/K [73]
/Pg 21 0 R
>>
endobj
1027 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [74]
/Pg 21 0 R
>>
endobj
1028 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [75]
/Pg 21 0 R
>>
endobj
1029 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (which is )
/K [76]
/Pg 21 0 R
>>
endobj
1030 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (in line with previous )
/K [77]
/Pg 21 0 R
>>
endobj
1031 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (observations that )
/K [78]
/Pg 21 0 R
>>
endobj
1032 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText
/K [79]
/Pg 21 0 R
>>
endobj
1033 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (The e)
/K [80]
/Pg 21 0 R
>>
endobj
1034 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (xpression levels )
/K [81]
/Pg 21 0 R
>>
endobj
1035 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (of )
/K [82]
/Pg 21 0 R
>>
endobj
1036 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (other PKC isoforms )
/K [83]
/Pg 21 0 R
>>
endobj
1037 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (also differ )
/K [84]
/Pg 21 0 R
>>
endobj
1038 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (between)
/K [85]
/Pg 21 0 R
>>
endobj
1039 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [86]
/Pg 21 0 R
>>
endobj
1040 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (cancer types)
/K [87]
/Pg 21 0 R
>>
endobj
1041 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [88]
/Pg 21 0 R
>>
endobj
1042 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (\(Fig. 2\))
/K [89]
/Pg 21 0 R
>>
endobj
1043 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [90]
/Pg 21 0 R
>>
endobj
1044 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText
/K [91]
/Pg 21 0 R
>>
endobj
1045 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (was )
/K [92]
/Pg 21 0 R
>>
endobj
1046 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (observed in B)
/K [93]
/Pg 21 0 R
>>
endobj
1047 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [94]
/Pg 21 0 R
>>
endobj
1048 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (cell lymphoma)
/K [95]
/Pg 21 0 R
>>
endobj
1049 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (,)
/K [96]
/Pg 21 0 R
>>
endobj
1050 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [97]
/Pg 21 0 R
>>
endobj
1051 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (while expression was lost in )
/K [98]
/Pg 21 0 R
>>
endobj
1052 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (a )
/K [99]
/Pg 21 0 R
>>
endobj
1053 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (melanoma cell line)
/K [100]
/Pg 21 0 R
>>
endobj
1054 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [101]
/Pg 21 0 R
>>
endobj
1055 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (\(for revi)
/K [102]
/Pg 21 0 R
>>
endobj
1056 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (ew see )
/K [103]
/Pg 21 0 R
>>
endobj
1057 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [104]
/Pg 21 0 R
>>
endobj
1058 0 obj
<<
/P 1154 0 R
/S /Span
/Type /StructElem
/ActualText (22)
/K [105]
/Pg 21 0 R
>>
endobj
1059 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [106]
/Pg 21 0 R
>>
endobj
1060 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [107]
/Pg 21 0 R
>>
endobj
1061 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [108]
/Pg 21 0 R
>>
endobj
1062 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [109]
/Pg 21 0 R
>>
endobj
1063 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (PKC)
/K [110]
/Pg 21 0 R
>>
endobj
1064 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText
/K [111]
/Pg 21 0 R
>>
endobj
1065 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (II)
/K [112]
/Pg 21 0 R
>>
endobj
1066 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [113]
/Pg 21 0 R
>>
endobj
1067 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (is also involved in enhancement of )
/K [114]
/Pg 21 0 R
>>
endobj
1068 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (B)
/K [115]
/Pg 21 0 R
>>
endobj
1069 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (-)
/K [116]
/Pg 21 0 R
>>
endobj
1070 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (cell receptor \()
/K [117]
/Pg 21 0 R
>>
endobj
1071 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (BCR)
/K [118]
/Pg 21 0 R
>>
endobj
1072 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\))
/K [119]
/Pg 21 0 R
>>
endobj
1073 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [120]
/Pg 21 0 R
>>
endobj
1074 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (signaling in ZAP)
/K [121]
/Pg 21 0 R
>>
endobj
1075 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (-)
/K [122]
/Pg 21 0 R
>>
endobj
1076 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (70 )
/K [123]
/Pg 21 0 R
>>
endobj
1077 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (expressing CLL cells )
/K [124]
/Pg 21 0 R
>>
endobj
1078 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\()
/K [125]
/Pg 21 0 R
>>
endobj
1079 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (23)
/K [126]
/Pg 21 0 R
>>
endobj
1080 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\))
/K [127]
/Pg 21 0 R
>>
endobj
1081 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [128]
/Pg 21 0 R
>>
endobj
1082 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [129]
/Pg 21 0 R
>>
endobj
1083 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (Even though)
/K [130]
/Pg 21 0 R
>>
endobj
1084 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [131]
/Pg 21 0 R
>>
endobj
1085 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText
/K [132]
/Pg 21 0 R
>>
endobj
1086 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (s)
/K [133]
/Pg 21 0 R
>>
endobj
1087 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [134]
/Pg 21 0 R
>>
endobj
1088 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (as a tumor suppressor )
/K [135]
/Pg 21 0 R
>>
endobj
1089 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (in many cancers, it )
/K [136]
/Pg 21 0 R
>>
endobj
1090 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (plays )
/K [137]
/Pg 21 0 R
>>
endobj
1091 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (the )
/K [138]
/Pg 21 0 R
>>
endobj
1092 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText
/K [139]
/Pg 21 0 R
>>
endobj
1093 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (-)
/K [140]
/Pg 21 0 R
>>
endobj
1094 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (CLL cells )
/K [141]
/Pg 21 0 R
>>
endobj
1095 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\()
/K [142]
/Pg 21 0 R
>>
endobj
1096 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (24)
/K [143]
/Pg 21 0 R
>>
endobj
1097 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\))
/K [144]
/Pg 21 0 R
>>
endobj
1098 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [145]
/Pg 21 0 R
>>
endobj
1099 0 obj
<<
/P 3586 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [146]
/Pg 21 0 R
>>
endobj
1100 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (Although mutation)
/K [147]
/Pg 21 0 R
>>
endobj
1101 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (s in PKC isoforms are)
/K [148]
/Pg 21 0 R
>>
endobj
1102 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [149]
/Pg 21 0 R
>>
endobj
1103 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (very rar)
/K [150]
/Pg 21 0 R
>>
endobj
1104 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (e, some earlier reports describe)
/K [151]
/Pg 21 0 R
>>
endobj
1105 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (d)
/K [152]
/Pg 21 0 R
>>
endobj
1106 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [153]
/Pg 21 0 R
>>
endobj
1107 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (certain )
/K [154]
/Pg 21 0 R
>>
endobj
1108 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText
/K [155]
/Pg 21 0 R
>>
endobj
1109 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (mutation )
/K [156]
/Pg 21 0 R
>>
endobj
1110 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (and )
/K [157]
/Pg 21 0 R
>>
endobj
1111 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (was initially identified in a subpopulation of pituitary tumors )
/K [158]
/Pg 21 0 R
>>
endobj
1112 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [159]
/Pg 21 0 R
>>
endobj
1113 0 obj
<<
/P 1157 0 R
/S /Span
/Type /StructElem
/ActualText (25)
/K [160]
/Pg 21 0 R
>>
endobj
1114 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [161]
/Pg 21 0 R
>>
endobj
1115 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (. Later this )
/K [162]
/Pg 21 0 R
>>
endobj
1116 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (mutation was)
/K [163]
/Pg 21 0 R
>>
endobj
1117 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [164]
/Pg 21 0 R
>>
endobj
1118 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (also observed in thyroid and breast cancers )
/K [165]
/Pg 21 0 R
>>
endobj
1119 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [166]
/Pg 21 0 R
>>
endobj
1120 0 obj
<<
/P 1158 0 R
/S /Span
/Type /StructElem
/ActualText (26)
/K [167]
/Pg 21 0 R
>>
endobj
1121 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (,)
/K [168]
/Pg 21 0 R
>>
endobj
1122 0 obj
<<
/P 1159 0 R
/S /Span
/Type /StructElem
/ActualText (27)
/K [169]
/Pg 21 0 R
>>
endobj
1123 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [170]
/Pg 21 0 R
>>
endobj
1124 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [171]
/Pg 21 0 R
>>
endobj
1125 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [172]
/Pg 21 0 R
>>
endobj
1126 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (Patients carrying )
/K [173]
/Pg 21 0 R
>>
endobj
1127 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText
/K [174]
/Pg 21 0 R
>>
endobj
1128 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [175]
/Pg 21 0 R
>>
endobj
1129 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (D294G mutation)
/K [176]
/Pg 21 0 R
>>
endobj
1130 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [177]
/Pg 21 0 R
>>
endobj
1131 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (is )
/K [178]
/Pg 21 0 R
>>
endobj
1132 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (linked t)
/K [179]
/Pg 21 0 R
>>
endobj
1133 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (o poor prognosis. The D)
/K [180]
/Pg 21 0 R
>>
endobj
1134 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (2)
/K [181]
/Pg 21 0 R
>>
endobj
1135 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (94G mutation is a loss of )
/K [182]
/Pg 21 0 R
>>
endobj
1136 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (function mutation )
/K [183]
/Pg 21 0 R
>>
endobj
1137 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [184]
/Pg 21 0 R
>>
endobj
1138 0 obj
<<
/P 1160 0 R
/S /Span
/Type /StructElem
/ActualText (28)
/K [185]
/Pg 21 0 R
>>
endobj
1139 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [186]
/Pg 21 0 R
>>
endobj
1140 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [187]
/Pg 21 0 R
>>
endobj
1141 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText
/K [188]
/Pg 21 0 R
>>
endobj
1142 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [189]
/Pg 21 0 R
>>
endobj
1143 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [190]
/Pg 21 0 R
>>
endobj
1144 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (The t)
/K [191]
/Pg 21 0 R
>>
endobj
1145 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (umor suppressor role of )
/K [192]
/Pg 21 0 R
>>
endobj
1146 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (PKC i)
/K [193]
/Pg 21 0 R
>>
endobj
1147 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (soforms has also been described )
/K [194]
/Pg 21 0 R
>>
endobj
1148 0 obj
<<
/P 3587 0 R
/S /Span
/Type /StructElem
/ActualText (in cancer, where treatment with ingenol mebutate \(also )
/K [195]
/Pg 21 0 R
>>
endobj
1149 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3888 0 R 963 0 R]
/Pg 21 0 R
>>
endobj
1150 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3889 0 R 1003 0 R]
/Pg 21 0 R
>>
endobj
1151 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3890 0 R 1010 0 R]
/Pg 21 0 R
>>
endobj
1152 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3891 0 R 1017 0 R]
/Pg 21 0 R
>>
endobj
1153 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3892 0 R 1026 0 R]
/Pg 21 0 R
>>
endobj
1154 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3893 0 R 1058 0 R]
/Pg 21 0 R
>>
endobj
1155 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3894 0 R 1079 0 R]
/Pg 21 0 R
>>
endobj
1156 0 obj
<<
/P 3586 0 R
/S /Link
/Type /StructElem
/K [3895 0 R 1096 0 R]
/Pg 21 0 R
>>
endobj
1157 0 obj
<<
/P 3587 0 R
/S /Link
/Type /StructElem
/K [3896 0 R 1113 0 R]
/Pg 21 0 R
>>
endobj
1158 0 obj
<<
/P 3587 0 R
/S /Link
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/K [0]
/Pg 24 0 R
>>
endobj
1556 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (various)
/K [1]
/Pg 24 0 R
>>
endobj
1557 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [2]
/Pg 24 0 R
>>
endobj
1558 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (ca)
/K [3]
/Pg 24 0 R
>>
endobj
1559 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (ncers. Since overexpression of )
/K [4]
/Pg 24 0 R
>>
endobj
1560 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (PKC isoforms play a role in cancer and )
/K [5]
/Pg 24 0 R
>>
endobj
1561 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (since )
/K [6]
/Pg 24 0 R
>>
endobj
1562 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (PKC is rarely mutated)
/K [7]
/Pg 24 0 R
>>
endobj
1563 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [8]
/Pg 24 0 R
>>
endobj
1564 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (in cancers)
/K [9]
/Pg 24 0 R
>>
endobj
1565 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (, it is important to )
/K [10]
/Pg 24 0 R
>>
endobj
1566 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (know PKC expression profile in CLL before )
/K [11]
/Pg 24 0 R
>>
endobj
1567 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (attempting to use this family of proteins as a target )
/K [12]
/Pg 24 0 R
>>
endobj
1568 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (of intervention)
/K [13]
/Pg 24 0 R
>>
endobj
1569 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [14]
/Pg 24 0 R
>>
endobj
1570 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (Although an)
/K [15]
/Pg 24 0 R
>>
endobj
1571 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [16]
/Pg 24 0 R
>>
endobj
1572 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (ea)
/K [17]
/Pg 24 0 R
>>
endobj
1573 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (rly)
/K [18]
/Pg 24 0 R
>>
endobj
1574 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [19]
/Pg 24 0 R
>>
endobj
1575 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (study de)
/K [20]
/Pg 24 0 R
>>
endobj
1576 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (monstrated)
/K [21]
/Pg 24 0 R
>>
endobj
1577 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [22]
/Pg 24 0 R
>>
endobj
1578 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (lower total PKC activity in CLL )
/K [23]
/Pg 24 0 R
>>
endobj
1579 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (as well )
/K [24]
/Pg 24 0 R
>>
endobj
1580 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (as )
/K [25]
/Pg 24 0 R
>>
endobj
1581 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (in)
/K [26]
/Pg 24 0 R
>>
endobj
1582 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [27]
/Pg 24 0 R
>>
endobj
1583 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (three )
/K [28]
/Pg 24 0 R
>>
endobj
1584 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (other )
/K [29]
/Pg 24 0 R
>>
endobj
1585 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (hematopoietic disorders, )
/K [30]
/Pg 24 0 R
>>
endobj
1586 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (a)
/K [31]
/Pg 24 0 R
>>
endobj
1587 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [32]
/Pg 24 0 R
>>
endobj
1588 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (higher PKC)
/K [33]
/Pg 24 0 R
>>
endobj
1589 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [34]
/Pg 24 0 R
>>
endobj
1590 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [35]
/Pg 24 0 R
>>
endobj
1591 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (expression )
/K [36]
/Pg 24 0 R
>>
endobj
1592 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (was found in CLL patients )
/K [37]
/Pg 24 0 R
>>
endobj
1593 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [38]
/Pg 24 0 R
>>
endobj
1594 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (compare)
/K [39]
/Pg 24 0 R
>>
endobj
1595 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (d)
/K [40]
/Pg 24 0 R
>>
endobj
1596 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [41]
/Pg 24 0 R
>>
endobj
1597 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (to )
/K [42]
/Pg 24 0 R
>>
endobj
1598 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [43]
/Pg 24 0 R
>>
endobj
1599 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [44]
/Pg 24 0 R
>>
endobj
1600 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (and)
/K [45]
/Pg 24 0 R
>>
endobj
1601 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [46]
/Pg 24 0 R
>>
endobj
1602 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [47]
/Pg 24 0 R
>>
endobj
1603 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [48]
/Pg 24 0 R
>>
endobj
1604 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [49]
/Pg 24 0 R
>>
endobj
1605 0 obj
<<
/P 1795 0 R
/S /Span
/Type /StructElem
/ActualText (53)
/K [50]
/Pg 24 0 R
>>
endobj
1606 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [51]
/Pg 24 0 R
>>
endobj
1607 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [52]
/Pg 24 0 R
>>
endobj
1608 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (A more recent)
/K [53]
/Pg 24 0 R
>>
endobj
1609 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [54]
/Pg 24 0 R
>>
endobj
1610 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (study )
/K [55]
/Pg 24 0 R
>>
endobj
1611 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (investigated a more )
/K [56]
/Pg 24 0 R
>>
endobj
1612 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (complete)
/K [57]
/Pg 24 0 R
>>
endobj
1613 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [58]
/Pg 24 0 R
>>
endobj
1614 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (profile of )
/K [59]
/Pg 24 0 R
>>
endobj
1615 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (PKC)
/K [60]
/Pg 24 0 R
>>
endobj
1616 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [61]
/Pg 24 0 R
>>
endobj
1617 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (isoform )
/K [62]
/Pg 24 0 R
>>
endobj
1618 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (ex)
/K [63]
/Pg 24 0 R
>>
endobj
1619 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (pression)
/K [64]
/Pg 24 0 R
>>
endobj
1620 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [65]
/Pg 24 0 R
>>
endobj
1621 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (While)
/K [66]
/Pg 24 0 R
>>
endobj
1622 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [67]
/Pg 24 0 R
>>
endobj
1623 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (all CLL patient samples)
/K [68]
/Pg 24 0 R
>>
endobj
1624 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [69]
/Pg 24 0 R
>>
endobj
1625 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (analyzed)
/K [70]
/Pg 24 0 R
>>
endobj
1626 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [71]
/Pg 24 0 R
>>
endobj
1627 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (displayed a significant level of)
/K [72]
/Pg 24 0 R
>>
endobj
1628 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [73]
/Pg 24 0 R
>>
endobj
1629 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (P)
/K [74]
/Pg 24 0 R
>>
endobj
1630 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [75]
/Pg 24 0 R
>>
endobj
1631 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (the )
/K [76]
/Pg 24 0 R
>>
endobj
1632 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [77]
/Pg 24 0 R
>>
endobj
1633 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (, )
/K [78]
/Pg 24 0 R
>>
endobj
1634 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [79]
/Pg 24 0 R
>>
endobj
1635 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [80]
/Pg 24 0 R
>>
endobj
1636 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [81]
/Pg 24 0 R
>>
endobj
1637 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (found)
/K [82]
/Pg 24 0 R
>>
endobj
1638 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [83]
/Pg 24 0 R
>>
endobj
1639 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (to )
/K [84]
/Pg 24 0 R
>>
endobj
1640 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (vary)
/K [85]
/Pg 24 0 R
>>
endobj
1641 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [86]
/Pg 24 0 R
>>
endobj
1642 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (from 0% to 67%)
/K [87]
/Pg 24 0 R
>>
endobj
1643 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [88]
/Pg 24 0 R
>>
endobj
1644 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [89]
/Pg 24 0 R
>>
endobj
1645 0 obj
<<
/P 1796 0 R
/S /Span
/Type /StructElem
/ActualText (54)
/K [90]
/Pg 24 0 R
>>
endobj
1646 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [91]
/Pg 24 0 R
>>
endobj
1647 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [92]
/Pg 24 0 R
>>
endobj
1648 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [93]
/Pg 24 0 R
>>
endobj
1649 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (Western blotting analysis of different )
/K [94]
/Pg 24 0 R
>>
endobj
1650 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (PKC isoform from hairy cell leukemia \(HCL\), normal B)
/K [95]
/Pg 24 0 R
>>
endobj
1651 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [96]
/Pg 24 0 R
>>
endobj
1652 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (c)
/K [97]
/Pg 24 0 R
>>
endobj
1653 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (ell and CLL cells )
/K [98]
/Pg 24 0 R
>>
endobj
1654 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (demonstrated)
/K [99]
/Pg 24 0 R
>>
endobj
1655 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [100]
/Pg 24 0 R
>>
endobj
1656 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (that )
/K [101]
/Pg 24 0 R
>>
endobj
1657 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (PKC)
/K [102]
/Pg 24 0 R
>>
endobj
1658 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [103]
/Pg 24 0 R
>>
endobj
1659 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (II)
/K [104]
/Pg 24 0 R
>>
endobj
1660 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [105]
/Pg 24 0 R
>>
endobj
1661 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (is the dominant isoform in CLL)
/K [106]
/Pg 24 0 R
>>
endobj
1662 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [107]
/Pg 24 0 R
>>
endobj
1663 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (but)
/K [108]
/Pg 24 0 R
>>
endobj
1664 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [109]
/Pg 24 0 R
>>
endobj
1665 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (the expression of )
/K [110]
/Pg 24 0 R
>>
endobj
1666 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [111]
/Pg 24 0 R
>>
endobj
1667 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [112]
/Pg 24 0 R
>>
endobj
1668 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (is)
/K [113]
/Pg 24 0 R
>>
endobj
1669 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [114]
/Pg 24 0 R
>>
endobj
1670 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (also)
/K [115]
/Pg 24 0 R
>>
endobj
1671 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [116]
/Pg 24 0 R
>>
endobj
1672 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (elevated \(Fig. 4\).)
/K [117]
/Pg 24 0 R
>>
endobj
1673 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [118]
/Pg 24 0 R
>>
endobj
1674 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (Moreover,)
/K [119]
/Pg 24 0 R
>>
endobj
1675 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [120]
/Pg 24 0 R
>>
endobj
1676 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (PKC)
/K [121]
/Pg 24 0 R
>>
endobj
1677 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText
/K [122]
/Pg 24 0 R
>>
endobj
1678 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (II)
/K [123]
/Pg 24 0 R
>>
endobj
1679 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [124]
/Pg 24 0 R
>>
endobj
1680 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (expression is 7 fold higher in CLL )
/K [125]
/Pg 24 0 R
>>
endobj
1681 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (compared)
/K [126]
/Pg 24 0 R
>>
endobj
1682 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [127]
/Pg 24 0 R
>>
endobj
1683 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (to t)
/K [128]
/Pg 24 0 R
>>
endobj
1684 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (hat in)
/K [129]
/Pg 24 0 R
>>
endobj
1685 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [130]
/Pg 24 0 R
>>
endobj
1686 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (HCL and B)
/K [131]
/Pg 24 0 R
>>
endobj
1687 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [132]
/Pg 24 0 R
>>
endobj
1688 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (cells )
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>>
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<<
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/K [134]
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>>
endobj
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<<
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/ActualText (55)
/K [135]
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>>
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>>
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<<
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>>
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<<
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>>
endobj
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<<
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/ActualText ( )
/K [139]
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>>
endobj
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<<
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/K [140]
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>>
endobj
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<<
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/ActualText (using microarray data from patien)
/K [141]
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>>
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<<
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/ActualText (t samples showed )
/K [142]
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>>
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<<
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/ActualText (an elevated expression of )
/K [143]
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>>
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<<
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/ActualText
/K [144]
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>>
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<<
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/ActualText (II)
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>>
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<<
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/ActualText ( )
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>>
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<<
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/ActualText (and )
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>>
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<<
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/ActualText
/K [148]
/Pg 24 0 R
>>
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<<
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/ActualText ( )
/K [149]
/Pg 24 0 R
>>
endobj
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<<
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/K [150]
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>>
endobj
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<<
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/ActualText (in CLL )
/K [151]
/Pg 24 0 R
>>
endobj
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<<
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/K [152]
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>>
endobj
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<<
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/ActualText (21)
/K [153]
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>>
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/K [154]
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>>
endobj
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<<
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/ActualText (. Differential expres)
/K [155]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText (sion of PKC isoforms in CLL patients )
/K [156]
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>>
endobj
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<<
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/Type /StructElem
/ActualText (opens )
/K [157]
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>>
endobj
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<<
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/Type /StructElem
/ActualText (for a )
/K [158]
/Pg 24 0 R
>>
endobj
1714 0 obj
<<
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/ActualText (possibility of targeting specific PKC isoforms in this disease. )
/K [159]
/Pg 24 0 R
>>
endobj
1715 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (Although multiple )
/K [160]
/Pg 24 0 R
>>
endobj
1716 0 obj
<<
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/S /Span
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/ActualText (PKC isoforms are found to be overexpressed in CLL, )
/K [161]
/Pg 24 0 R
>>
endobj
1717 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (several CLL studies have pointed towards )
/K [162]
/Pg 24 0 R
>>
endobj
1718 0 obj
<<
/P 3597 0 R
/S /Span
/Type /StructElem
/ActualText (PKC)
/K [163]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText
/K [164]
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>>
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<<
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/K [165]
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>>
endobj
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<<
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/ActualText (.)
/K [166]
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>>
endobj
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<<
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/ActualText ( )
/K [167]
/Pg 24 0 R
>>
endobj
1723 0 obj
<<
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/ActualText (These)
/K [168]
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>>
endobj
1724 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [169]
/Pg 24 0 R
>>
endobj
1725 0 obj
<<
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/Type /StructElem
/ActualText (studies )
/K [170]
/Pg 24 0 R
>>
endobj
1726 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (suggests that)
/K [171]
/Pg 24 0 R
>>
endobj
1727 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [172]
/Pg 24 0 R
>>
endobj
1728 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (elevated expression of P)
/K [173]
/Pg 24 0 R
>>
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<<
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/S /Span
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/ActualText (KC)
/K [174]
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>>
endobj
1730 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText
/K [175]
/Pg 24 0 R
>>
endobj
1731 0 obj
<<
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/Type /StructElem
/ActualText (II)
/K [176]
/Pg 24 0 R
>>
endobj
1732 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [177]
/Pg 24 0 R
>>
endobj
1733 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (correlates with aggressive)
/K [178]
/Pg 24 0 R
>>
endobj
1734 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [179]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText (disease)
/K [180]
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>>
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1736 0 obj
<<
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/ActualText ( )
/K [181]
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>>
endobj
1737 0 obj
<<
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/K [182]
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>>
endobj
1738 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [183]
/Pg 24 0 R
>>
endobj
1739 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (in CLL)
/K [184]
/Pg 24 0 R
>>
endobj
1740 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [185]
/Pg 24 0 R
>>
endobj
1741 0 obj
<<
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/Type /StructElem
/ActualText (\()
/K [186]
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>>
endobj
1742 0 obj
<<
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/ActualText (56)
/K [187]
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>>
endobj
1743 0 obj
<<
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/K [188]
/Pg 24 0 R
>>
endobj
1744 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (58)
/K [189]
/Pg 24 0 R
>>
endobj
1745 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\))
/K [190]
/Pg 24 0 R
>>
endobj
1746 0 obj
<<
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/ActualText (.)
/K [191]
/Pg 24 0 R
>>
endobj
1747 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [192]
/Pg 24 0 R
>>
endobj
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<<
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/S /Span
/Type /StructElem
/ActualText (Furthermore)
/K [193]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText (,)
/K [194]
/Pg 24 0 R
>>
endobj
1750 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [195]
/Pg 24 0 R
>>
endobj
1751 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (e)
/K [196]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText (levated )
/K [197]
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>>
endobj
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<<
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/ActualText (PKC)
/K [198]
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>>
endobj
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<<
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/ActualText
/K [199]
/Pg 24 0 R
>>
endobj
1755 0 obj
<<
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/ActualText (II)
/K [200]
/Pg 24 0 R
>>
endobj
1756 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [201]
/Pg 24 0 R
>>
endobj
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<<
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/K [202]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText ( )
/K [203]
/Pg 24 0 R
>>
endobj
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<<
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/K [204]
/Pg 24 0 R
>>
endobj
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<<
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/K [205]
/Pg 24 0 R
>>
endobj
1761 0 obj
<<
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/ActualText (promote)
/K [206]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText ( )
/K [207]
/Pg 24 0 R
>>
endobj
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<<
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/ActualText (carcinogenesis )
/K [208]
/Pg 24 0 R
>>
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<<
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/ActualText (\()
/K [209]
/Pg 24 0 R
>>
endobj
1765 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (59)
/K [210]
/Pg 24 0 R
>>
endobj
1766 0 obj
<<
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/ActualText (,)
/K [211]
/Pg 24 0 R
>>
endobj
1767 0 obj
<<
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/ActualText (60)
/K [212]
/Pg 24 0 R
>>
endobj
1768 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (\))
/K [213]
/Pg 24 0 R
>>
endobj
1769 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (. )
/K [214]
/Pg 24 0 R
>>
endobj
1770 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (Therefor)
/K [215]
/Pg 24 0 R
>>
endobj
1771 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (e)
/K [216]
/Pg 24 0 R
>>
endobj
1772 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [217]
/Pg 24 0 R
>>
endobj
1773 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (targeting PKC)
/K [218]
/Pg 24 0 R
>>
endobj
1774 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText
/K [219]
/Pg 24 0 R
>>
endobj
1775 0 obj
<<
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/Type /StructElem
/ActualText (II)
/K [220]
/Pg 24 0 R
>>
endobj
1776 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [221]
/Pg 24 0 R
>>
endobj
1777 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (might provide a novel appr)
/K [222]
/Pg 24 0 R
>>
endobj
1778 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (oach in )
/K [223]
/Pg 24 0 R
>>
endobj
1779 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (treatment of CLL.)
/K [224]
/Pg 24 0 R
>>
endobj
1780 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [225]
/Pg 24 0 R
>>
endobj
1781 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText ( )
/K [226]
/Pg 24 0 R
>>
endobj
1782 0 obj
<<
/P 3598 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [227]
/Pg 24 0 R
>>
endobj
1783 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (7)
/K [228]
/Pg 24 0 R
>>
endobj
1784 0 obj
<<
/P 3599 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [229]
/Pg 24 0 R
>>
endobj
1785 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (The r)
/K [230]
/Pg 24 0 R
>>
endobj
1786 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (ole of )
/K [231]
/Pg 24 0 R
>>
endobj
1787 0 obj
<<
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/ActualText (PKC )
/K [232]
/Pg 24 0 R
>>
endobj
1788 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (isoforms)
/K [233]
/Pg 24 0 R
>>
endobj
1789 0 obj
<<
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/Type /StructElem
/ActualText ( )
/K [234]
/Pg 24 0 R
>>
endobj
1790 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (in CLL )
/K [235]
/Pg 24 0 R
>>
endobj
1791 0 obj
<<
/P 3599 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [236]
/Pg 24 0 R
>>
endobj
1792 0 obj
<<
/P 3600 0 R
/S /Span
/Type /StructElem
/ActualText (It is now widely accepted that BCR)
/K [237]
/Pg 24 0 R
>>
endobj
1793 0 obj
<<
/P 3600 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [238]
/Pg 24 0 R
>>
endobj
1794 0 obj
<<
/P 3600 0 R
/S /Span
/Type /StructElem
/ActualText (signaling is of importance for CLL pathogenesis. )
/K [239]
/Pg 24 0 R
>>
endobj
1795 0 obj
<<
/P 3597 0 R
/S /Link
/Type /StructElem
/K [3917 0 R 1605 0 R]
/Pg 24 0 R
>>
endobj
1796 0 obj
<<
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/S /Link
/Type /StructElem
/K [3918 0 R 1645 0 R]
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>>
endobj
1797 0 obj
<<
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/K [3919 0 R 1690 0 R]
/Pg 24 0 R
>>
endobj
1798 0 obj
<<
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/S /Link
/Type /StructElem
/K [3920 0 R 1708 0 R]
/Pg 24 0 R
>>
endobj
1799 0 obj
<<
/P 3597 0 R
/S /Link
/Type /StructElem
/K [3921 0 R 1742 0 R 1743 0 R 1744 0 R]
/Pg 24 0 R
>>
endobj
1800 0 obj
<<
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/S /Link
/Type /StructElem
/K [3922 0 R 1765 0 R]
/Pg 24 0 R
>>
endobj
1801 0 obj
<<
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/S /Link
/Type /StructElem
/K [3923 0 R 1767 0 R]
/Pg 24 0 R
>>
endobj
1802 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (Mutation)
/K [0]
/Pg 25 0 R
>>
endobj
1803 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (s)
/K [1]
/Pg 25 0 R
>>
endobj
1804 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [2]
/Pg 25 0 R
>>
endobj
1805 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (of BCR sequences contributes to the survival and proliferation)
/K [3]
/Pg 25 0 R
>>
endobj
1806 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [4]
/Pg 25 0 R
>>
endobj
1807 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (of B)
/K [5]
/Pg 25 0 R
>>
endobj
1808 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [6]
/Pg 25 0 R
>>
endobj
1809 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (cells)
/K [7]
/Pg 25 0 R
>>
endobj
1810 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [8]
/Pg 25 0 R
>>
endobj
1811 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (The )
/K [9]
/Pg 25 0 R
>>
endobj
1812 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (expression of the )
/K [10]
/Pg 25 0 R
>>
endobj
1813 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (cell surface molecules CD38 )
/K [11]
/Pg 25 0 R
>>
endobj
1814 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (further supports this process. Survival signals )
/K [12]
/Pg 25 0 R
>>
endobj
1815 0 obj
<<
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/S /Span
/Type /StructElem
/ActualText (from )
/K [13]
/Pg 25 0 R
>>
endobj
1816 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (the )
/K [14]
/Pg 25 0 R
>>
endobj
1817 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (cell surface )
/K [15]
/Pg 25 0 R
>>
endobj
1818 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (B)
/K [16]
/Pg 25 0 R
>>
endobj
1819 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [17]
/Pg 25 0 R
>>
endobj
1820 0 obj
<<
/P 3601 0 R
/S /Span
/Type /StructElem
/ActualText (cell receptor)
/K [18]
/Pg 25 0 R
>>
endobj
1821 0 obj
<<
/P 3601 0 R
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/S /Span
/Type /StructElem
/ActualText (. The exact )
/K [151]
/Pg 25 0 R
>>
endobj
1954 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (mechan)
/K [152]
/Pg 25 0 R
>>
endobj
1955 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (ism)
/K [153]
/Pg 25 0 R
>>
endobj
1956 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [154]
/Pg 25 0 R
>>
endobj
1957 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (behind this regulation)
/K [155]
/Pg 25 0 R
>>
endobj
1958 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [156]
/Pg 25 0 R
>>
endobj
1959 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (was unknown until investigators observed that )
/K [157]
/Pg 25 0 R
>>
endobj
1960 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText
/K [158]
/Pg 25 0 R
>>
endobj
1961 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (II)
/K [159]
/Pg 25 0 R
>>
endobj
1962 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [160]
/Pg 25 0 R
>>
endobj
1963 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (is )
/K [161]
/Pg 25 0 R
>>
endobj
1964 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (constitutively associated with lipid)
/K [162]
/Pg 25 0 R
>>
endobj
1965 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [163]
/Pg 25 0 R
>>
endobj
1966 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (rafts in ZAP70 positive CLL cells )
/K [164]
/Pg 25 0 R
>>
endobj
1967 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [165]
/Pg 25 0 R
>>
endobj
1968 0 obj
<<
/P 1987 0 R
/S /Span
/Type /StructElem
/ActualText (23)
/K [166]
/Pg 25 0 R
>>
endobj
1969 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [167]
/Pg 25 0 R
>>
endobj
1970 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (.)
/K [168]
/Pg 25 0 R
>>
endobj
1971 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [169]
/Pg 25 0 R
>>
endobj
1972 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (Since, ZAP70 is )
/K [170]
/Pg 25 0 R
>>
endobj
1973 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (constitutively associated with lipid)
/K [171]
/Pg 25 0 R
>>
endobj
1974 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [172]
/Pg 25 0 R
>>
endobj
1975 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (rafts, it probably recruits )
/K [173]
/Pg 25 0 R
>>
endobj
1976 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText
/K [174]
/Pg 25 0 R
>>
endobj
1977 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [175]
/Pg 25 0 R
>>
endobj
1978 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (to the rafts)
/K [176]
/Pg 25 0 R
>>
endobj
1979 0 obj
<<
/P 3603 0 R
/S /Span
/Type /StructElem
/ActualText (. This )
/K [177]
/Pg 25 0 R
>>
endobj
1980 0 obj
<<
/P 3601 0 R
/S /Link
/Type /StructElem
/K [3924 0 R 1831 0 R]
/Pg 25 0 R
>>
endobj
1981 0 obj
<<
/P 3601 0 R
/S /Link
/Type /StructElem
/K [3925 0 R 1858 0 R]
/Pg 25 0 R
>>
endobj
1982 0 obj
<<
/P 3602 0 R
/S /Link
/Type /StructElem
/K [3926 0 R 1881 0 R]
/Pg 25 0 R
>>
endobj
1983 0 obj
<<
/P 3602 0 R
/S /Link
/Type /StructElem
/K [3927 0 R 1905 0 R]
/Pg 25 0 R
>>
endobj
1984 0 obj
<<
/P 3602 0 R
/S /Link
/Type /StructElem
/K [3928 0 R 1914 0 R]
/Pg 25 0 R
>>
endobj
1985 0 obj
<<
/P 3602 0 R
/S /Link
/Type /StructElem
/K [3929 0 R 1921 0 R]
/Pg 25 0 R
>>
endobj
1986 0 obj
<<
/P 3603 0 R
/S /Link
/Type /StructElem
/K [3930 0 R 1949 0 R 1950 0 R 1951 0 R]
/Pg 25 0 R
>>
endobj
1987 0 obj
<<
/P 3603 0 R
/S /Link
/Type /StructElem
/K [3931 0 R 1968 0 R]
/Pg 25 0 R
>>
endobj
1988 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (recruitment enhances )
/K [0]
/Pg 26 0 R
>>
endobj
1989 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText
/K [1]
/Pg 26 0 R
>>
endobj
1990 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [2]
/Pg 26 0 R
>>
endobj
1991 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (activation and)
/K [3]
/Pg 26 0 R
>>
endobj
1992 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [4]
/Pg 26 0 R
>>
endobj
1993 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (activated )
/K [5]
/Pg 26 0 R
>>
endobj
1994 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText
/K [6]
/Pg 26 0 R
>>
endobj
1995 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (II)
/K [7]
/Pg 26 0 R
>>
endobj
1996 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [8]
/Pg 26 0 R
>>
endobj
1997 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (translocates to the mitochondria )
/K [9]
/Pg 26 0 R
>>
endobj
1998 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (where it )
/K [10]
/Pg 26 0 R
>>
endobj
1999 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (associates with and )
/K [11]
/Pg 26 0 R
>>
endobj
2000 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (phosphorylate)
/K [12]
/Pg 26 0 R
>>
endobj
2001 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (s the)
/K [13]
/Pg 26 0 R
>>
endobj
2002 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [14]
/Pg 26 0 R
>>
endobj
2003 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (anti)
/K [15]
/Pg 26 0 R
>>
endobj
2004 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [16]
/Pg 26 0 R
>>
endobj
2005 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (apoptotic protein BCL2 )
/K [17]
/Pg 26 0 R
>>
endobj
2006 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (and )
/K [18]
/Pg 26 0 R
>>
endobj
2007 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (the pro)
/K [19]
/Pg 26 0 R
>>
endobj
2008 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [20]
/Pg 26 0 R
>>
endobj
2009 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (apoptotic )
/K [21]
/Pg 26 0 R
>>
endobj
2010 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (protein )
/K [22]
/Pg 26 0 R
>>
endobj
2011 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (BIM)
/K [23]
/Pg 26 0 R
>>
endobj
2012 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (EL)
/K [24]
/Pg 26 0 R
>>
endobj
2013 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [25]
/Pg 26 0 R
>>
endobj
2014 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [26]
/Pg 26 0 R
>>
endobj
2015 0 obj
<<
/P 2157 0 R
/S /Span
/Type /StructElem
/ActualText (23)
/K [27]
/Pg 26 0 R
>>
endobj
2016 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [28]
/Pg 26 0 R
>>
endobj
2017 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [29]
/Pg 26 0 R
>>
endobj
2018 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (While p)
/K [30]
/Pg 26 0 R
>>
endobj
2019 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (hosphorylation of)
/K [31]
/Pg 26 0 R
>>
endobj
2020 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [32]
/Pg 26 0 R
>>
endobj
2021 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (BIM)
/K [33]
/Pg 26 0 R
>>
endobj
2022 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (EL)
/K [34]
/Pg 26 0 R
>>
endobj
2023 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [35]
/Pg 26 0 R
>>
endobj
2024 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (directs this protein )
/K [36]
/Pg 26 0 R
>>
endobj
2025 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (for )
/K [37]
/Pg 26 0 R
>>
endobj
2026 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (proteosomal degradation,)
/K [38]
/Pg 26 0 R
>>
endobj
2027 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [39]
/Pg 26 0 R
>>
endobj
2028 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (BCL2)
/K [40]
/Pg 26 0 R
>>
endobj
2029 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [41]
/Pg 26 0 R
>>
endobj
2030 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (phosphorylation enhances this process.)
/K [42]
/Pg 26 0 R
>>
endobj
2031 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [43]
/Pg 26 0 R
>>
endobj
2032 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (Therefor)
/K [44]
/Pg 26 0 R
>>
endobj
2033 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (e,)
/K [45]
/Pg 26 0 R
>>
endobj
2034 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [46]
/Pg 26 0 R
>>
endobj
2035 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText
/K [47]
/Pg 26 0 R
>>
endobj
2036 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [48]
/Pg 26 0 R
>>
endobj
2037 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (mediated anti)
/K [49]
/Pg 26 0 R
>>
endobj
2038 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [50]
/Pg 26 0 R
>>
endobj
2039 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (apoptotic effects in)
/K [51]
/Pg 26 0 R
>>
endobj
2040 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [52]
/Pg 26 0 R
>>
endobj
2041 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (CLL)
/K [53]
/Pg 26 0 R
>>
endobj
2042 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [54]
/Pg 26 0 R
>>
endobj
2043 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [55]
/Pg 26 0 R
>>
endobj
2044 0 obj
<<
/P 2158 0 R
/S /Span
/Type /StructElem
/ActualText (69)
/K [56]
/Pg 26 0 R
>>
endobj
2045 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [57]
/Pg 26 0 R
>>
endobj
2046 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [58]
/Pg 26 0 R
>>
endobj
2047 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (is mediated through early activation of NF)
/K [59]
/Pg 26 0 R
>>
endobj
2048 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [60]
/Pg 26 0 R
>>
endobj
2049 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText
/K [61]
/Pg 26 0 R
>>
endobj
2050 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (pathway as well as down regulation of BIM)
/K [62]
/Pg 26 0 R
>>
endobj
2051 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (EL)
/K [63]
/Pg 26 0 R
>>
endobj
2052 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [64]
/Pg 26 0 R
>>
endobj
2053 0 obj
<<
/P 3604 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [65]
/Pg 26 0 R
>>
endobj
2054 0 obj
<<
/P 3605 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [66]
/Pg 26 0 R
>>
endobj
2055 0 obj
<<
/P 3606 0 R
/S /Span
/Type /StructElem
/ActualText (8)
/K [67]
/Pg 26 0 R
>>
endobj
2056 0 obj
<<
/P 3606 0 R
/S /Span
/Type /StructElem
/ActualText (. )
/K [68]
/Pg 26 0 R
>>
endobj
2057 0 obj
<<
/P 3606 0 R
/S /Span
/Type /StructElem
/ActualText (PKC inhibitors)
/K [69]
/Pg 26 0 R
>>
endobj
2058 0 obj
<<
/P 3606 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [70]
/Pg 26 0 R
>>
endobj
2059 0 obj
<<
/P 3606 0 R
/S /Span
/Type /StructElem
/ActualText (in CLL)
/K [71]
/Pg 26 0 R
>>
endobj
2060 0 obj
<<
/P 3606 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [72]
/Pg 26 0 R
>>
endobj
2061 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (Treatment of CLL generally involves combination chemotherapies which generate )
/K [73]
/Pg 26 0 R
>>
endobj
2062 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (severe)
/K [74]
/Pg 26 0 R
>>
endobj
2063 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [75]
/Pg 26 0 R
>>
endobj
2064 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (side)
/K [76]
/Pg 26 0 R
>>
endobj
2065 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (-)
/K [77]
/Pg 26 0 R
>>
endobj
2066 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (effects. Targeted therapy allows more specific )
/K [78]
/Pg 26 0 R
>>
endobj
2067 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (treatment option. This approach appears to )
/K [79]
/Pg 26 0 R
>>
endobj
2068 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (b)
/K [80]
/Pg 26 0 R
>>
endobj
2069 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (e )
/K [81]
/Pg 26 0 R
>>
endobj
2070 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (more popular but still suffers from )
/K [82]
/Pg 26 0 R
>>
endobj
2071 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (moderate)
/K [83]
/Pg 26 0 R
>>
endobj
2072 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [84]
/Pg 26 0 R
>>
endobj
2073 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (response and secondary resistance to the drugs. )
/K [85]
/Pg 26 0 R
>>
endobj
2074 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (Recent studies suggest that mutations in)
/K [86]
/Pg 26 0 R
>>
endobj
2075 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [87]
/Pg 26 0 R
>>
endobj
2076 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (the)
/K [88]
/Pg 26 0 R
>>
endobj
2077 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [89]
/Pg 26 0 R
>>
endobj
2078 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (inhibitor binding pocket confers secondary )
/K [90]
/Pg 26 0 R
>>
endobj
2079 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (resistance)
/K [91]
/Pg 26 0 R
>>
endobj
2080 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [92]
/Pg 26 0 R
>>
endobj
2081 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (\()
/K [93]
/Pg 26 0 R
>>
endobj
2082 0 obj
<<
/P 2159 0 R
/S /Span
/Type /StructElem
/ActualText (70)
/K [94]
/Pg 26 0 R
>>
endobj
2083 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (\))
/K [95]
/Pg 26 0 R
>>
endobj
2084 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (. Thus)
/K [96]
/Pg 26 0 R
>>
endobj
2085 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText (,)
/K [97]
/Pg 26 0 R
>>
endobj
2086 0 obj
<<
/P 3607 0 R
/S /Span
/Type /StructElem
/ActualText ( )
/K [98]
/Pg 26 0 R
>>
endobj
2087 0 obj
<<
/P 3607 0 R
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