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Medicinsk limning av lungsäcken

Arvastson, Per (2008)
Department of Statistics
Abstract
A statistical analysis has been performed on a pharmacological study from the Lung department of Medical clinic, UsiL. The intention of the study was to explore, especially from a pallative aspect, treatment of exceptional fluid manifestations in pleura caused by cancer.
The patients were recruited between 1993 and 1997. They were randomized either to the drug Atabrine or to the drug Bleomycin. However due to the characteristics of the drugs it was not possible to perform this study as a double blind study. Except for an anomaly in one age group and in one gender group, we have found no signs or statistical indications that the randomization has been perfomed in an improper way. In this study it is the relapse rate that stands out.... (More)
A statistical analysis has been performed on a pharmacological study from the Lung department of Medical clinic, UsiL. The intention of the study was to explore, especially from a pallative aspect, treatment of exceptional fluid manifestations in pleura caused by cancer.
The patients were recruited between 1993 and 1997. They were randomized either to the drug Atabrine or to the drug Bleomycin. However due to the characteristics of the drugs it was not possible to perform this study as a double blind study. Except for an anomaly in one age group and in one gender group, we have found no signs or statistical indications that the randomization has been perfomed in an improper way. In this study it is the relapse rate that stands out. Patients treated with Bleomycin has a significant higher relapse rate than those treated with Atabrine (p=0.009). From a pallative aspect this is an important result.
With oddsratio over radiographic evidences of pleural disease there could be found a significant difference in lung quality between the two groups. Patients treated with Atabrine has a significant higher oddsratio, 1.62, to achieve the highest quality (p=0.0374).
The survival times could be followed all the way for all patients. No significant difference in the survival functions or the median survival times between the two treatments, Atabrine and Bleomycin, were found. (Less)
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author
Arvastson, Per
supervisor
organization
year
type
M2 - Bachelor Degree
subject
keywords
klinisk studie, oddskvot test, weibull-regression, överlevnadsanalys, Statistics, operations research, programming, actuarial mathematics, Statistik, operationsanalys, programmering, aktuariematematik
language
Swedish
id
1644212
date added to LUP
2008-08-18
date last changed
2010-08-05 12:39:37
@misc{1644212,
  abstract     = {A statistical analysis has been performed on a pharmacological study from the Lung department of Medical clinic, UsiL. The intention of the study was to explore, especially from a pallative aspect, treatment of exceptional fluid manifestations in pleura caused by cancer.
The patients were recruited between 1993 and 1997. They were randomized either to the drug Atabrine or to the drug Bleomycin. However due to the characteristics of the drugs it was not possible to perform this study as a double blind study. Except for an anomaly in one age group and in one gender group, we have found no signs or statistical indications that the randomization has been perfomed in an improper way. In this study it is the relapse rate that stands out. Patients treated with Bleomycin has a significant higher relapse rate than those treated with Atabrine (p=0.009). From a pallative aspect this is an important result.
With oddsratio over radiographic evidences of pleural disease there could be found a significant difference in lung quality between the two groups. Patients treated with Atabrine has a significant higher oddsratio, 1.62, to achieve the highest quality (p=0.0374).
The survival times could be followed all the way for all patients. No significant difference in the survival functions or the median survival times between the two treatments, Atabrine and Bleomycin, were found.},
  author       = {Arvastson, Per},
  keyword      = {klinisk studie,oddskvot test,weibull-regression,överlevnadsanalys,Statistics, operations research, programming, actuarial mathematics,Statistik, operationsanalys, programmering, aktuariematematik},
  language     = {swe},
  note         = {Student Paper},
  title        = {Medicinsk limning av lungsäcken},
  year         = {2008},
}