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Simplified human exposure assessment of chemicals with the help of intake fraction?

Björkdahl, Christina (2004) In LUTVDG/TVBB--5150--SE VBR920
Division of Fire Safety Engineering
Risk Management and Safety Engineering
Division of Risk Management and Societal Safety
Abstract
The concept of intake fraction (iF) relates the emitted amount of a particular chemical to the subsequent human intake of that substance. Intake fractions have been calculated for more than 300 substances, spanning a range of up to seven orders of magnitude. It has furthermore been suggested that intake fractions can be estimated based on a few properties of the chemical. In this study, the following two questions are discussed: Can this type of relationships be used for simplified human exposure assessment? Does high total production volume of a chemical imply high human exposure? In this report the available research on the concept of intake fraction is scrutinized, including the suggested methods to calculate intake fractions. It is... (More)
The concept of intake fraction (iF) relates the emitted amount of a particular chemical to the subsequent human intake of that substance. Intake fractions have been calculated for more than 300 substances, spanning a range of up to seven orders of magnitude. It has furthermore been suggested that intake fractions can be estimated based on a few properties of the chemical. In this study, the following two questions are discussed: Can this type of relationships be used for simplified human exposure assessment? Does high total production volume of a chemical imply high human exposure? In this report the available research on the concept of intake fraction is scrutinized, including the suggested methods to calculate intake fractions. It is concluded that variability and uncertainty in the intake fractions estimated so far is considerable, implying that the concept needs further development before it can be used for simplified exposure analysis in the regulatory context. It is furthermore concluded that there seem to be a positive correlation between the amount of a chemical emitted into the environment and the magnitude of human exposure to that particular substances. This does however not imply that a high total production volume of a chemical necessarily will result in high human exposure. (Less)
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author
Björkdahl, Christina
supervisor
organization
course
VBR920
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Intake fraction, chemicals, human exposure assessment, human exposure analysis, emission-to-intake, relationship, risk assessment, kemikalier, exponeringsbedömning, exponeringsanalys, emission-till-intags samband, riskbedömning.
publication/series
LUTVDG/TVBB--5150--SE
report number
5150
ISSN
1402-3504
language
English
id
1688904
date added to LUP
2011-01-20 17:29:02
date last changed
2014-03-10 10:40:34
@misc{1688904,
  abstract     = {The concept of intake fraction (iF) relates the emitted amount of a particular chemical to the subsequent human intake of that substance. Intake fractions have been calculated for more than 300 substances, spanning a range of up to seven orders of magnitude. It has furthermore been suggested that intake fractions can be estimated based on a few properties of the chemical. In this study, the following two questions are discussed: Can this type of relationships be used for simplified human exposure assessment? Does high total production volume of a chemical imply high human exposure? In this report the available research on the concept of intake fraction is scrutinized, including the suggested methods to calculate intake fractions. It is concluded that variability and uncertainty in the intake fractions estimated so far is considerable, implying that the concept needs further development before it can be used for simplified exposure analysis in the regulatory context. It is furthermore concluded that there seem to be a positive correlation between the amount of a chemical emitted into the environment and the magnitude of human exposure to that particular substances. This does however not imply that a high total production volume of a chemical necessarily will result in high human exposure.},
  author       = {Björkdahl, Christina},
  issn         = {1402-3504},
  keyword      = {Intake fraction,chemicals,human exposure assessment,human exposure analysis,emission-to-intake,relationship,risk assessment,kemikalier,exponeringsbedömning,exponeringsanalys,emission-till-intags samband,riskbedömning.},
  language     = {eng},
  note         = {Student Paper},
  series       = {LUTVDG/TVBB--5150--SE},
  title        = {Simplified human exposure assessment of chemicals with the help of intake fraction?},
  year         = {2004},
}