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Korttidseffekt av rTMS jämfört med ECT i samband med behandling av depression: En metaanalys

Näslund, Daniel LU (2012) PSYK01 20112
Department of Psychology
Abstract
This meta-analysis examines the antidepressive efficacy of repetitive transcranial magnetic stimulation (rTMS) when compared to electroconvulsive therapy (ECT) in a short term perspective. A literature search was performed with the intention to include all randomized clinical trials. A total of seven articles were included. Results showed that both rTMS and ECT had a significant antidepressive effect (p<0.05), measured in score difference on Hamilton Depression Rating Scale (HDRS). The effect was not significant (p=0.0599) between the two treatment groups in a comparison on HDRS. Effect sizes were calculated and were in all cases but one larger in the ECT group. An effect size difference of d=0.76 (p=0.0160) in favour for ECT was found... (More)
This meta-analysis examines the antidepressive efficacy of repetitive transcranial magnetic stimulation (rTMS) when compared to electroconvulsive therapy (ECT) in a short term perspective. A literature search was performed with the intention to include all randomized clinical trials. A total of seven articles were included. Results showed that both rTMS and ECT had a significant antidepressive effect (p<0.05), measured in score difference on Hamilton Depression Rating Scale (HDRS). The effect was not significant (p=0.0599) between the two treatment groups in a comparison on HDRS. Effect sizes were calculated and were in all cases but one larger in the ECT group. An effect size difference of d=0.76 (p=0.0160) in favour for ECT was found when compared to rTMS. The studies were heterogeneous and included a smaller sample. To conclude rTMS still has to be seen as an experimental method and that further studies are needed before implementing it in a daily clinical praxis. (Less)
Abstract (Swedish)
Metaanlysen undersöker antidepressiv effekt av repetitiv transkranial magnetstimulering (rTMS) jämfört med elektrokonvulsiv terapi (ECT) i ett korttidsperspektiv. En litteratursökning genomfördes med avsikt att inkludera samtliga randomiserade kliniska prövningar där de två behandlingsteknikerna ställdes mot varandra. Totalt sju artiklar inkluderades. Resultatet visade att både rTMS och ECT hade en signifikant antidepressiv effekt (p<0.05), mätt i poängskillnad på Hamilton Depression Rating Scale (HDRS). Effekten var inte signifikant (p=0.0599) mellan behandlingsgrupperna vid jämförelse av HDRS. Effektstorlekar beräknades och dessa var större i samtliga fall utom ett för ECT-gruppen. Effektstorleksskillnaden var d=0.76 (p=0.0160) till... (More)
Metaanlysen undersöker antidepressiv effekt av repetitiv transkranial magnetstimulering (rTMS) jämfört med elektrokonvulsiv terapi (ECT) i ett korttidsperspektiv. En litteratursökning genomfördes med avsikt att inkludera samtliga randomiserade kliniska prövningar där de två behandlingsteknikerna ställdes mot varandra. Totalt sju artiklar inkluderades. Resultatet visade att både rTMS och ECT hade en signifikant antidepressiv effekt (p<0.05), mätt i poängskillnad på Hamilton Depression Rating Scale (HDRS). Effekten var inte signifikant (p=0.0599) mellan behandlingsgrupperna vid jämförelse av HDRS. Effektstorlekar beräknades och dessa var större i samtliga fall utom ett för ECT-gruppen. Effektstorleksskillnaden var d=0.76 (p=0.0160) till fördel för ECT när denna ställdes mot rTMS. Studierna var dock heterogena och inkluderade ett mindre antal deltagare. Slutsatsen blir därför att rTMS fortsatt får ses som en experimentell metod och att ytterligare studier behövs innan den kan implementeras i vardaglig klinisk praxis. (Less)
Please use this url to cite or link to this publication:
author
Näslund, Daniel LU
supervisor
organization
course
PSYK01 20112
year
type
M2 - Bachelor Degree
subject
keywords
electroconvulsive therapy, meta-analysis, repetitive transcranial magnetic stimulation, elektrokonvulsiv terapi, metaanalys depression, repetitiv transkranial magnetstimulering, depression
language
Swedish
id
2437344
date added to LUP
2012-04-10 16:22:36
date last changed
2012-04-10 16:22:36
@misc{2437344,
  abstract     = {This meta-analysis examines the antidepressive efficacy of repetitive transcranial magnetic stimulation (rTMS) when compared to electroconvulsive therapy (ECT) in a short term perspective. A literature search was performed with the intention to include all randomized clinical trials. A total of seven articles were included. Results showed that both rTMS and ECT had a significant antidepressive effect (p<0.05), measured in score difference on Hamilton Depression Rating Scale (HDRS). The effect was not significant (p=0.0599) between the two treatment groups in a comparison on HDRS. Effect sizes were calculated and were in all cases but one larger in the ECT group. An effect size difference of d=0.76 (p=0.0160) in favour for ECT was found when compared to rTMS. The studies were heterogeneous and included a smaller sample. To conclude rTMS still has to be seen as an experimental method and that further studies are needed before implementing it in a daily clinical praxis.},
  author       = {Näslund, Daniel},
  keyword      = {electroconvulsive therapy,meta-analysis,repetitive transcranial magnetic stimulation,elektrokonvulsiv terapi,metaanalys depression,repetitiv transkranial magnetstimulering,depression},
  language     = {swe},
  note         = {Student Paper},
  title        = {Korttidseffekt av rTMS jämfört med ECT i samband med behandling av depression: En metaanalys},
  year         = {2012},
}