Advanced

FOLLICLE STIMULATING HORMONE RECEPTOR POLYMORPHISMS AS MARKERS OF POOR OVARIAN RESPONSE IN WOMEN RECEIVING HORMONAL HYPERSTIMULATION PRIOR TO IN VITRO FERTILIZATION

Kyhlberg, Erika LU and Larsson, Linda (2012) LÄKM01 20121
MD Programme
Abstract
Abstract
Poor ovarian response (POR) in IVF can lead to cancelling a treatment cycle which is a physical and
mental strain on the patient. To beforehand identify the patient’s ovarian response would possibly
prevent the risk of unsuccessful stimulation. POR has been linked to polymorphisms in the FSH
receptor. Using the FSHR genotype as prognostic criteria would permit individualisation of dosing
and optimisation of treatment.
Objective: This study aimed to investigate whether women with the Ser/Ser680 FSHR genotype
were more prone to be POR than women with Asn/Ser or Asn/Asn genotypes.
Methods: 47 POR women and 52 controls were genotyped. Blood or saliva samples were collected
for DNA extraction. Analyses regarding a possible... (More)
Abstract
Poor ovarian response (POR) in IVF can lead to cancelling a treatment cycle which is a physical and
mental strain on the patient. To beforehand identify the patient’s ovarian response would possibly
prevent the risk of unsuccessful stimulation. POR has been linked to polymorphisms in the FSH
receptor. Using the FSHR genotype as prognostic criteria would permit individualisation of dosing
and optimisation of treatment.
Objective: This study aimed to investigate whether women with the Ser/Ser680 FSHR genotype
were more prone to be POR than women with Asn/Ser or Asn/Asn genotypes.
Methods: 47 POR women and 52 controls were genotyped. Blood or saliva samples were collected
for DNA extraction. Analyses regarding a possible association between the Ser/Ser680 polymorphism
and POR were done.
Results: Genotyping patients subdivided according to ovarian response showed that in the POR
group, 13% of women had the Ser/Ser FSHR genotype, 45% Asn/Asn and 43% Asn/Ser. In the
control group, 19% had the Ser/Ser, 29% Asn/Asn and 52% Asn/Ser.
Hence, there was no evidence of the Ser/Ser genotype being more prevalent in the POR group. The
Ser/Ser presented the OR of 0.61 of being POR, this figure not being statistically significantly
different from the other genotypes combined (Asn/Ser, Asn/Asn) (95% CI: 0.20 – 1.8; p=0.38).
In conclusion, our study did not find that women with the Ser/Ser680 FSHR genotype were more
prone to be POR. (Less)
Please use this url to cite or link to this publication:
author
Kyhlberg, Erika LU and Larsson, Linda
supervisor
organization
course
LÄKM01 20121
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Poor responder, in vitro fertilisation, polymorphism, follicle stimulating hormone receptor
language
English
id
2627398
date added to LUP
2012-08-24 11:02:54
date last changed
2012-08-24 11:02:54
@misc{2627398,
  abstract     = {Abstract
Poor ovarian response (POR) in IVF can lead to cancelling a treatment cycle which is a physical and
mental strain on the patient. To beforehand identify the patient’s ovarian response would possibly
prevent the risk of unsuccessful stimulation. POR has been linked to polymorphisms in the FSH
receptor. Using the FSHR genotype as prognostic criteria would permit individualisation of dosing
and optimisation of treatment.
Objective: This study aimed to investigate whether women with the Ser/Ser680 FSHR genotype
were more prone to be POR than women with Asn/Ser or Asn/Asn genotypes.
Methods: 47 POR women and 52 controls were genotyped. Blood or saliva samples were collected
for DNA extraction. Analyses regarding a possible association between the Ser/Ser680 polymorphism
and POR were done.
Results: Genotyping patients subdivided according to ovarian response showed that in the POR
group, 13% of women had the Ser/Ser FSHR genotype, 45% Asn/Asn and 43% Asn/Ser. In the
control group, 19% had the Ser/Ser, 29% Asn/Asn and 52% Asn/Ser.
Hence, there was no evidence of the Ser/Ser genotype being more prevalent in the POR group. The
Ser/Ser presented the OR of 0.61 of being POR, this figure not being statistically significantly
different from the other genotypes combined (Asn/Ser, Asn/Asn) (95% CI: 0.20 – 1.8; p=0.38).
In conclusion, our study did not find that women with the Ser/Ser680 FSHR genotype were more
prone to be POR.},
  author       = {Kyhlberg, Erika and Larsson, Linda},
  keyword      = {Poor responder,in vitro fertilisation,polymorphism,follicle stimulating hormone receptor},
  language     = {eng},
  note         = {Student Paper},
  title        = {FOLLICLE STIMULATING HORMONE RECEPTOR POLYMORPHISMS AS MARKERS OF POOR OVARIAN RESPONSE IN WOMEN RECEIVING HORMONAL HYPERSTIMULATION PRIOR TO IN VITRO FERTILIZATION},
  year         = {2012},
}