A minimalistic model for peptide fibril formation
(2012) FYTK01 20121Computational Biology and Biological Physics - Undergoing reorganization
- Abstract
- A lattice model for fibril formation on the basis of general peptide interactions is presented. Fibrils are well-structured protein aggregates and a key phenomenon in many diseases, among them Alzheimer.
We study the model’s equilibrium and kinetic properties using Wang-Landau sampling and a Metropolis Monte Carlo algorithm with cluster moves. The peptides are shown to form ordered fibrilar aggregates at low temperatures, while being non-aggregated at high temperatures. A sharp
transition separates the two phases. In the kinetic simulations, the growth of fibrils is associated with two lag phases.
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/2796876
- author
- Linnemann, Niels Siegbert LU
- supervisor
-
- Anders Irbäck LU
- Stefan Wallin LU
- organization
- course
- FYTK01 20121
- year
- 2012
- type
- M2 - Bachelor Degree
- subject
- keywords
- fibril, fibril formation, protein physics, amyloid fibril, model for fibril formation
- language
- English
- id
- 2796876
- date added to LUP
- 2013-01-25 09:08:14
- date last changed
- 2017-10-06 16:44:14
@misc{2796876,
abstract = {{A lattice model for fibril formation on the basis of general peptide interactions is presented. Fibrils are well-structured protein aggregates and a key phenomenon in many diseases, among them Alzheimer.
We study the model’s equilibrium and kinetic properties using Wang-Landau sampling and a Metropolis Monte Carlo algorithm with cluster moves. The peptides are shown to form ordered fibrilar aggregates at low temperatures, while being non-aggregated at high temperatures. A sharp
transition separates the two phases. In the kinetic simulations, the growth of fibrils is associated with two lag phases.}},
author = {{Linnemann, Niels Siegbert}},
language = {{eng}},
note = {{Student Paper}},
title = {{A minimalistic model for peptide fibril formation}},
year = {{2012}},
}