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Optimization of nanowire photodiode devices for neuronal cell survival

Biswas, Shantonu LU (2013) FYSM60 20122
Department of Physics
Solid State Physics
Abstract
Designing efficient artificial retina is one of the prime research focuses for medical engineers. The long term goal of this project is to assess if artificial photoreceptors such as nanowire photodiodes could be suitable for neuronal stimulation. To investigate this, different nanowire substrates (Si NWs, GaP NWs) and nanowire photodiodes (InP NW-photodiodes) were fabricated on substrates in ordered arrays and characterized them by SEM. Retinal cells were cultured and characterized using fluorescent microscopy on the different nanowire substrates. Cell interaction with bare substrate and NW-substrate were also studied. We report that SiNWs growth parameter depends on densities of the patterns. We observed that cells prefer GaP NWs over... (More)
Designing efficient artificial retina is one of the prime research focuses for medical engineers. The long term goal of this project is to assess if artificial photoreceptors such as nanowire photodiodes could be suitable for neuronal stimulation. To investigate this, different nanowire substrates (Si NWs, GaP NWs) and nanowire photodiodes (InP NW-photodiodes) were fabricated on substrates in ordered arrays and characterized them by SEM. Retinal cells were cultured and characterized using fluorescent microscopy on the different nanowire substrates. Cell interaction with bare substrate and NW-substrate were also studied. We report that SiNWs growth parameter depends on densities of the patterns. We observed that cells prefer GaP NWs over than bare GaP substrate, specially axonal outgrowth is higher on GaP NWs than GaP bare substrate. We also demonstrated that achieving axonal guidance using nanowires is possible. As part of the next level experiment of this project an optical setup was developed aiming to stimulate the neurons with photodiodes and to record action potential in neurons by Ca+ imaging technique. (Less)
Please use this url to cite or link to this publication:
author
Biswas, Shantonu LU
supervisor
organization
course
FYSM60 20122
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Nanotechnology, nanowire, photodiodes, solar cell, neurons, action potential.
language
English
id
3633832
date added to LUP
2013-04-18 23:15:41
date last changed
2013-04-18 23:15:41
@misc{3633832,
  abstract     = {Designing efficient artificial retina is one of the prime research focuses for medical engineers. The long term goal of this project is to assess if artificial photoreceptors such as nanowire photodiodes could be suitable for neuronal stimulation. To investigate this, different nanowire substrates (Si NWs, GaP NWs) and nanowire photodiodes (InP NW-photodiodes) were fabricated on substrates in ordered arrays and characterized them by SEM. Retinal cells were cultured and characterized using fluorescent microscopy on the different nanowire substrates. Cell interaction with bare substrate and NW-substrate were also studied. We report that SiNWs growth parameter depends on densities of the patterns. We observed that cells prefer GaP NWs over than bare GaP substrate, specially axonal outgrowth is higher on GaP NWs than GaP bare substrate. We also demonstrated that achieving axonal guidance using nanowires is possible. As part of the next level experiment of this project an optical setup was developed aiming to stimulate the neurons with photodiodes and to record action potential in neurons by Ca+ imaging technique.},
  author       = {Biswas, Shantonu},
  keyword      = {Nanotechnology,nanowire,photodiodes,solar cell,neurons,action potential.},
  language     = {eng},
  note         = {Student Paper},
  title        = {Optimization of nanowire photodiode devices for neuronal cell survival},
  year         = {2013},
}