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Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections

Mousavi, Monirehalsadat LU (2013) FYSM60 20131
Department of Physics
Abstract
Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, continues to be a challenge. Achieving complete resection is limited by difficulty in intraoperative discrimination between normal and residual tumor cells. This project contributes to the development and evaluation of a fiber-optical based fluorescence/reflectance spectroscopy system as an intraoperative guiding tool, using $\delta$-aminolevulinic acid (ALA)-induced Protoporphyrin IX (PpIX). The main aim is to combine the diagnostic potential of reflectance and fluorescence to improve clinical applicability. In this context, 5 LEDs coupled to a hand-held optical fiber was employed to deliver UV/visible light to the sample sequentially.... (More)
Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, continues to be a challenge. Achieving complete resection is limited by difficulty in intraoperative discrimination between normal and residual tumor cells. This project contributes to the development and evaluation of a fiber-optical based fluorescence/reflectance spectroscopy system as an intraoperative guiding tool, using $\delta$-aminolevulinic acid (ALA)-induced Protoporphyrin IX (PpIX). The main aim is to combine the diagnostic potential of reflectance and fluorescence to improve clinical applicability. In this context, 5 LEDs coupled to a hand-held optical fiber was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies. (Less)
Please use this url to cite or link to this publication:
author
Mousavi, Monirehalsadat LU
supervisor
organization
course
FYSM60 20131
year
type
H2 - Master's Degree (Two Years)
subject
language
English
id
3972404
date added to LUP
2013-11-12 08:48:11
date last changed
2013-11-12 08:48:11
@misc{3972404,
  abstract     = {Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, continues to be a challenge. Achieving complete resection is limited by difficulty in intraoperative discrimination between normal and residual tumor cells. This project contributes to the development and evaluation of a fiber-optical based fluorescence/reflectance spectroscopy system as an intraoperative guiding tool, using $\delta$-aminolevulinic acid (ALA)-induced Protoporphyrin IX (PpIX). The main aim is to combine the diagnostic potential of reflectance and fluorescence to improve clinical applicability. In this context, 5 LEDs coupled to a hand-held optical fiber was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies.},
  author       = {Mousavi, Monirehalsadat},
  language     = {eng},
  note         = {Student Paper},
  title        = {Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections},
  year         = {2013},
}