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Ultra-sensitive diagnostic method based on Surface Enhanced Raman Spectroscopy on plasmonic beads in suspension

Liu, Yujun LU (2013) FYSM31 20131
Department of Physics
Solid State Physics
Abstract (Swedish)
In this work, surface enhanced Raman spectroscopy (SERS) was combined with dielectrophoresis (DEP) to realize a controllable in situ detection method of enhanced Raman signals from molecules in suspension environment. Polymer beads coated with gold nanoparticles were prepared as SERS ‘hot spot’ substrates. Several DEP electrode designs were evaluated and the stripe electrode succeeded in manipulating the particles to form clusters for creating strong plasmon coupling. We use the finite difference time domain (FDTD) simulation method to evaluate the electric field enhancement for the SERS effect. Enhanced Raman spectrum of 4-mercaptobenzoic acid (4-MBA) and glucose molecule were obtained, and switchable enhancement was achieved for... (More)
In this work, surface enhanced Raman spectroscopy (SERS) was combined with dielectrophoresis (DEP) to realize a controllable in situ detection method of enhanced Raman signals from molecules in suspension environment. Polymer beads coated with gold nanoparticles were prepared as SERS ‘hot spot’ substrates. Several DEP electrode designs were evaluated and the stripe electrode succeeded in manipulating the particles to form clusters for creating strong plasmon coupling. We use the finite difference time domain (FDTD) simulation method to evaluate the electric field enhancement for the SERS effect. Enhanced Raman spectrum of 4-mercaptobenzoic acid (4-MBA) and glucose molecule were obtained, and switchable enhancement was achieved for functionalized 4-MBA molecules. (Less)
Please use this url to cite or link to this publication:
author
Liu, Yujun LU
supervisor
organization
course
FYSM31 20131
year
type
H2 - Master's Degree (Two Years)
subject
keywords
SERS, Raman, DEP, gold nanoparticle, enhancement
language
English
id
4005098
date added to LUP
2013-09-09 22:51:45
date last changed
2013-09-09 22:51:45
@misc{4005098,
  abstract     = {In this work, surface enhanced Raman spectroscopy (SERS) was combined with dielectrophoresis (DEP) to realize a controllable in situ detection method of enhanced Raman signals from molecules in suspension environment. Polymer beads coated with gold nanoparticles were prepared as SERS ‘hot spot’ substrates. Several DEP electrode designs were evaluated and the stripe electrode succeeded in manipulating the particles to form clusters for creating strong plasmon coupling. We use the finite difference time domain (FDTD) simulation method to evaluate the electric field enhancement for the SERS effect. Enhanced Raman spectrum of 4-mercaptobenzoic acid (4-MBA) and glucose molecule were obtained, and switchable enhancement was achieved for functionalized 4-MBA molecules.},
  author       = {Liu, Yujun},
  keyword      = {SERS,Raman,DEP,gold nanoparticle,enhancement},
  language     = {eng},
  note         = {Student Paper},
  title        = {Ultra-sensitive diagnostic method based on Surface Enhanced Raman Spectroscopy on plasmonic beads in suspension},
  year         = {2013},
}