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Simulations and Experiments of Magnetic and Mechanical Effects in Magneto-Motive Ultrasound Imaging

Baruda, Esayas Atile LU (2013) FYSM60 20131
Department of Physics
Abstract
superparamagnetic nanoparticles have been used for different applications,
especially for MRI as a contrast agent. Recently, a new technique called
Magneto-motive ultrasound (MMUS) imaging was introduced making
these particles also work for as a contrast agent for ultrasound. This
method uses a time varying magnetic field as an excitation source to
provoke motion of magnetic nanoparticles laden in for instance a tissue
mimicking phantom. Ultrasound is then used to detect and image the
motion. In this project both experimentation and simulation have been
performed to show that motions induced outside nanoparticle laden regions
are a result of mechanical wave motion. Various concentrations inside a
tissue mimicking phantom have... (More)
superparamagnetic nanoparticles have been used for different applications,
especially for MRI as a contrast agent. Recently, a new technique called
Magneto-motive ultrasound (MMUS) imaging was introduced making
these particles also work for as a contrast agent for ultrasound. This
method uses a time varying magnetic field as an excitation source to
provoke motion of magnetic nanoparticles laden in for instance a tissue
mimicking phantom. Ultrasound is then used to detect and image the
motion. In this project both experimentation and simulation have been
performed to show that motions induced outside nanoparticle laden regions
are a result of mechanical wave motion. Various concentrations inside a
tissue mimicking phantom have been modeled.
As the results from the experimental and simulation show, there is a
correspondence between the experimental and the simulation results. The
triggered motion by the magnetic field makes the magnetic inserts to
displace and thereby the surrounding motion, in all directions. However,
ultrasound detects only the z-component movement. Considering the zcomponent displacement of the magnetic inserts and the area in between,
in both the experimental and the simulation results, both the inserts and the area in between happen to displace with different amplitudes and with a π-radian phase shift. This suggests that, there is a clear contrast between the magnetic nanoparticles and the surrounding where the inserts are labeled. This helps to differentiate the magnetic inserts from the surrounding where the inserts are embedded by considering the phase shift. (Less)
Please use this url to cite or link to this publication:
author
Baruda, Esayas Atile LU
supervisor
organization
course
FYSM60 20131
year
type
H2 - Master's Degree (Two Years)
subject
language
English
id
4228591
date added to LUP
2017-07-04 15:46:44
date last changed
2017-07-04 15:46:44
@misc{4228591,
  abstract     = {superparamagnetic nanoparticles have been used for different applications,
especially for MRI as a contrast agent. Recently, a new technique called
Magneto-motive ultrasound (MMUS) imaging was introduced making
these particles also work for as a contrast agent for ultrasound. This
method uses a time varying magnetic field as an excitation source to
provoke motion of magnetic nanoparticles laden in for instance a tissue
mimicking phantom. Ultrasound is then used to detect and image the
motion. In this project both experimentation and simulation have been
performed to show that motions induced outside nanoparticle laden regions
are a result of mechanical wave motion. Various concentrations inside a
tissue mimicking phantom have been modeled.
As the results from the experimental and simulation show, there is a
correspondence between the experimental and the simulation results. The
triggered motion by the magnetic field makes the magnetic inserts to
displace and thereby the surrounding motion, in all directions. However,
ultrasound detects only the z-component movement. Considering the zcomponent displacement of the magnetic inserts and the area in between,
in both the experimental and the simulation results, both the inserts and the area in between happen to displace with different amplitudes and with a π-radian phase shift. This suggests that, there is a clear contrast between the magnetic nanoparticles and the surrounding where the inserts are labeled. This helps to differentiate the magnetic inserts from the surrounding where the inserts are embedded by considering the phase shift.},
  author       = {Baruda, Esayas Atile},
  language     = {eng},
  note         = {Student Paper},
  title        = {Simulations and Experiments of Magnetic and Mechanical Effects in Magneto-Motive Ultrasound Imaging},
  year         = {2013},
}