The effect of epidural anaesthesia on TCI dosage, depth of anaesthesia and the need for hemodynamic treatment during lung surgery.A prospective observational pilot study
(2014) ANSM50 20141Department of Health Sciences
- Abstract
- Aim: To investigate the effect of general anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment. A comparison between general anaesthesia (GA) alone and general anaesthesia combined with epidural anaesthesia (GA+EDA).
Background: There are some uncertainties in the literature whether epidural anaesthesia has any effect on general anaesthesia governed by Target Controlled Infusion (TCI). Therefore the present study will investigate the effect of epidural anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment.
Methods: The present study was performed as a prospective observational study at Skåne University Hospital in Sweden during spring of 2014. Twenty... (More) - Aim: To investigate the effect of general anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment. A comparison between general anaesthesia (GA) alone and general anaesthesia combined with epidural anaesthesia (GA+EDA).
Background: There are some uncertainties in the literature whether epidural anaesthesia has any effect on general anaesthesia governed by Target Controlled Infusion (TCI). Therefore the present study will investigate the effect of epidural anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment.
Methods: The present study was performed as a prospective observational study at Skåne University Hospital in Sweden during spring of 2014. Twenty patient receiving propofol and remifentanil delivered with TCI with or without an epidural anaesthesia participated. Ten patients received a general anaesthesia (GA) and ten patients received an epidural anaesthesia along with general anaesthesia (GA+EDA). Bispectral index (BIS) values, dosages of propofol, remifentanil and norepinephrine as well as hemodynamic variables were recorded and analysed every 15 minutes until 90 minutes of anaesthesia.
Findings: There were no statistically differences between the two groups, GA vs GA+EDA regarding the BIS-values (p=1.000), propofol (p=0.938), remifentanil (p=0.970) and norepinephrine (p=0.145). The hemodynamic variables indicate significantly lower diastolic blood pressure in group GA+EDA in the time-point 15 min (p=0.047) and 75 min (p= 0.004), and heart rate was significant lower in group GA+EDA in time-point 45 min, p= 0.047. Otherwise no significant difference could be found between the two groups.
Conclusion: The results indicate that an epidural anaesthesia in conjunction with TCI has no effect on depth of anaesthesia, dosage of medication and the need of hemodynamic treatment. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/4457733
- author
- Andréasson, Kristina LU and Brinck, Christina LU
- supervisor
- organization
- course
- ANSM50 20141
- year
- 2014
- type
- H1 - Master's Degree (One Year)
- subject
- keywords
- Bispectral index, Target controlled infusion, Anesthesia epidural, Anesthesia general, Hemodynamic treatment
- language
- English
- id
- 4457733
- date added to LUP
- 2014-06-10 09:13:25
- date last changed
- 2015-12-14 13:21:34
@misc{4457733,
abstract = {{Aim: To investigate the effect of general anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment. A comparison between general anaesthesia (GA) alone and general anaesthesia combined with epidural anaesthesia (GA+EDA).
Background: There are some uncertainties in the literature whether epidural anaesthesia has any effect on general anaesthesia governed by Target Controlled Infusion (TCI). Therefore the present study will investigate the effect of epidural anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment.
Methods: The present study was performed as a prospective observational study at Skåne University Hospital in Sweden during spring of 2014. Twenty patient receiving propofol and remifentanil delivered with TCI with or without an epidural anaesthesia participated. Ten patients received a general anaesthesia (GA) and ten patients received an epidural anaesthesia along with general anaesthesia (GA+EDA). Bispectral index (BIS) values, dosages of propofol, remifentanil and norepinephrine as well as hemodynamic variables were recorded and analysed every 15 minutes until 90 minutes of anaesthesia.
Findings: There were no statistically differences between the two groups, GA vs GA+EDA regarding the BIS-values (p=1.000), propofol (p=0.938), remifentanil (p=0.970) and norepinephrine (p=0.145). The hemodynamic variables indicate significantly lower diastolic blood pressure in group GA+EDA in the time-point 15 min (p=0.047) and 75 min (p= 0.004), and heart rate was significant lower in group GA+EDA in time-point 45 min, p= 0.047. Otherwise no significant difference could be found between the two groups.
Conclusion: The results indicate that an epidural anaesthesia in conjunction with TCI has no effect on depth of anaesthesia, dosage of medication and the need of hemodynamic treatment.}},
author = {{Andréasson, Kristina and Brinck, Christina}},
language = {{eng}},
note = {{Student Paper}},
title = {{The effect of epidural anaesthesia on TCI dosage, depth of anaesthesia and the need for hemodynamic treatment during lung surgery.A prospective observational pilot study}},
year = {{2014}},
}