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Modelling and robust estimation of AV node function during AF

Garoldi, Gennaro LU and Iozzia, Luca LU (2014) EEM820 20141
Department of Biomedical Engineering
Abstract
Objective: The purpose of the present thesis is to enrich the robustness of a statistical atrioventricular (AV) node model during atrial Fibrillation (AF). The model takes into account electrophysiological properties as the two pathways, their refractory periods and concealed conduction; these pathways are located between sinoatrial (SA) and AV node. It is highly desirable understanding of the AV node function, in order to achieve optimal arrhythmia management for those patients affected by AF, which is the most common arrhythmia. Methods: The simulation has been improved by introducing a new parameter that represents the probability of an impulse choosing either one of the two pathways. Exploration data has been conducted keeping fixed a... (More)
Objective: The purpose of the present thesis is to enrich the robustness of a statistical atrioventricular (AV) node model during atrial Fibrillation (AF). The model takes into account electrophysiological properties as the two pathways, their refractory periods and concealed conduction; these pathways are located between sinoatrial (SA) and AV node. It is highly desirable understanding of the AV node function, in order to achieve optimal arrhythmia management for those patients affected by AF, which is the most common arrhythmia. Methods: The simulation has been improved by introducing a new parameter that represents the probability of an impulse choosing either one of the two pathways. Exploration data has been conducted keeping fixed a set of parameters while varying one of them. Results: The model concerns a relationship between the probability of an atrial impulse passing through (output parameter, a) and choosing (input parameter, g) either one of two pathway. To test its accuracy and precision mean absolute error (MAE) and root mean square error (RMSE) have been calculated for different g, obtaining, MAE = 3:8_8:2023_10 (Less)
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author
Garoldi, Gennaro LU and Iozzia, Luca LU
supervisor
organization
course
EEM820 20141
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Atrial Fibrillation (AF), atrioventricular node (AV node), Carvedilol, Diltiazem, dual pathways, Holter recordings, maximum likelihood estimation (MLE), minimum least squares (MLS), metoprolol, refractory period, RR intervals, statistical modeling, Verapamil.
language
English
additional info
2014-05
id
4530372
date added to LUP
2014-07-03 13:29:31
date last changed
2014-10-08 14:47:33
@misc{4530372,
  abstract     = {{Objective: The purpose of the present thesis is to enrich the robustness of a statistical atrioventricular (AV) node model during atrial Fibrillation (AF). The model takes into account electrophysiological properties as the two pathways, their refractory periods and concealed conduction; these pathways are located between sinoatrial (SA) and AV node. It is highly desirable understanding of the AV node function, in order to achieve optimal arrhythmia management for those patients affected by AF, which is the most common arrhythmia. Methods: The simulation has been improved by introducing a new parameter that represents the probability of an impulse choosing either one of the two pathways. Exploration data has been conducted keeping fixed a set of parameters while varying one of them. Results: The model concerns a relationship between the probability of an atrial impulse passing through (output parameter, a) and choosing (input parameter, g) either one of two pathway. To test its accuracy and precision mean absolute error (MAE) and root mean square error (RMSE) have been calculated for different g, obtaining, MAE = 3:8_8:2023_10}},
  author       = {{Garoldi, Gennaro and Iozzia, Luca}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Modelling and robust estimation of AV node function during AF}},
  year         = {{2014}},
}