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Identification of novel signal transduction proteins of importance for FLT3 signaling in acute myeloid leukemia

Moharram, Sausan (2016) MOBT01 20152
Degree Projects in Molecular Biology
Popular Abstract
Novel therapeutic strategy for acute myeloid leukemia


Acute myeloid leukemia, AML, is a type of blood cancer that is generally common among elder ages with median age of 65 years old. Around 350 cases per year are diagnosed with AML in Sweden. It is characterized by infiltration of cancer cells in the bone marrow leading to insufficient production of different blood cell types including the immune cells. The pathogenesis of the disease is quite well understood but the treatment options are very limited due to resistance of the existing drugs. It is worth noting that AML is a heterogeneous disease, which means that not all leukemic patients have the same malignancy. AML has different types of mutations which contribute to its... (More)
Novel therapeutic strategy for acute myeloid leukemia


Acute myeloid leukemia, AML, is a type of blood cancer that is generally common among elder ages with median age of 65 years old. Around 350 cases per year are diagnosed with AML in Sweden. It is characterized by infiltration of cancer cells in the bone marrow leading to insufficient production of different blood cell types including the immune cells. The pathogenesis of the disease is quite well understood but the treatment options are very limited due to resistance of the existing drugs. It is worth noting that AML is a heterogeneous disease, which means that not all leukemic patients have the same malignancy. AML has different types of mutations which contribute to its heterogeneity. Therefore, it is necessary to identify mutations and find strategies to overcome drug resistance due to these mutations.

Mutations in the FLT3 receptor is one of the most common mutations in AML. Many drugs fail to show complete cure and the disease relapses in the vast majority of patients, and is more likely to be the death-related cause of AML. In our study, we tried to understand how cancer cells utilize FLT3 to proliferate and survive and how other proteins regulate the effect of the FLT3 mutant in cancer cells. We used a panel of different adaptor proteins to assess their ability to interact with FLT3. One interesting protein, SLAP2 showed the higher capability to bind FLT3. Further studies using different biochemical and molecular biological techniques defined the role of SLAP2 in controlling FLT3-mediated pathogenesis. SLAP2 showed adequate ability to control tumor cell growth signals and reduce tumor cell transformation through negative regulation of FLT3 receptor activity. Therefore, FLT3 interacting protein like SLAP2 could be a potential alternative drug target against AML.

Supervisor: Julhash Uddin Kazi
Master’s Degree Project in Molecular Biology 60 credits 2016
Department of Biology, Lund University
Subject of degree project: Cancer Research (Less)
Please use this url to cite or link to this publication:
author
Moharram, Sausan
supervisor
organization
course
MOBT01 20152
year
type
H2 - Master's Degree (Two Years)
subject
language
English
id
8870790
date added to LUP
2016-04-07 11:26:47
date last changed
2016-04-07 11:26:47
@misc{8870790,
  author       = {Moharram, Sausan},
  language     = {eng},
  note         = {Student Paper},
  title        = {Identification of novel signal transduction proteins of importance for FLT3 signaling in acute myeloid leukemia},
  year         = {2016},
}