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Impulse response analysis of neuromodulation for the treatment of motor symptoms in Parkinson’s disease

Hedström, Staffan (2016) In MSc Theses
Department of Automatic Control
Abstract
In adaptive deep brain stimulation, a treatment for motor symptoms in Parkinson’s disease, the target of the stimulus is usually in the sub-thalamic nucleus or the globus pallidus. In this thesis, a new stimulus target called reticular thalamus is investigated in a rat model of Parkinson’s disease. The responses to the stimulus were recorded from both local field potentials and action potentials from neurons in a live animal implanted with an electrode array and stimulus electrode. The local field potentials were used to investigate the state of a rat, to categorise healthy, parkinsonian and dyskinetic states, to create a response to the stimulus used for investigating the effects of the new stimulus target and to try find the transfer... (More)
In adaptive deep brain stimulation, a treatment for motor symptoms in Parkinson’s disease, the target of the stimulus is usually in the sub-thalamic nucleus or the globus pallidus. In this thesis, a new stimulus target called reticular thalamus is investigated in a rat model of Parkinson’s disease. The responses to the stimulus were recorded from both local field potentials and action potentials from neurons in a live animal implanted with an electrode array and stimulus electrode. The local field potentials were used to investigate the state of a rat, to categorise healthy, parkinsonian and dyskinetic states, to create a response to the stimulus used for investigating the effects of the new stimulus target and to try find the transfer function (turns input into output) to the brain of a rat model of Parkinson’s disease with the Markov parameter realisation algorithm. The new stimulus target showed interesting and clear visual responses from the rat and set the structures in the basal ganglia in a 5-10 Hz ringing for half a second as revealed by a peristimulus time histogram. A power spectral density diagram revealed characteristics previously shown to be correlated with Parkinson’s disease. The transfer function created from the responses was not able to predict the responses to other stimulation protocols other than the one used to build the transfer function, possibly due to the fact that the stimulus target was more effectively inhibited by the higher frequency stimulus protocols, so that the biological properties changed the system. (Less)
Please use this url to cite or link to this publication:
author
Hedström, Staffan
supervisor
organization
year
type
H3 - Professional qualifications (4 Years - )
subject
publication/series
MSc Theses
report number
TFRT-5993
ISSN
0280-5316
language
English
id
8882067
date added to LUP
2016-06-17 09:13:21
date last changed
2016-06-17 09:13:21
@misc{8882067,
  abstract     = {In adaptive deep brain stimulation, a treatment for motor symptoms in Parkinson’s disease, the target of the stimulus is usually in the sub-thalamic nucleus or the globus pallidus. In this thesis, a new stimulus target called reticular thalamus is investigated in a rat model of Parkinson’s disease. The responses to the stimulus were recorded from both local field potentials and action potentials from neurons in a live animal implanted with an electrode array and stimulus electrode. The local field potentials were used to investigate the state of a rat, to categorise healthy, parkinsonian and dyskinetic states, to create a response to the stimulus used for investigating the effects of the new stimulus target and to try find the transfer function (turns input into output) to the brain of a rat model of Parkinson’s disease with the Markov parameter realisation algorithm. The new stimulus target showed interesting and clear visual responses from the rat and set the structures in the basal ganglia in a 5-10 Hz ringing for half a second as revealed by a peristimulus time histogram. A power spectral density diagram revealed characteristics previously shown to be correlated with Parkinson’s disease. The transfer function created from the responses was not able to predict the responses to other stimulation protocols other than the one used to build the transfer function, possibly due to the fact that the stimulus target was more effectively inhibited by the higher frequency stimulus protocols, so that the biological properties changed the system.},
  author       = {Hedström, Staffan},
  issn         = {0280-5316},
  language     = {eng},
  note         = {Student Paper},
  series       = {MSc Theses},
  title        = {Impulse response analysis of neuromodulation for the treatment of motor symptoms in Parkinson’s disease},
  year         = {2016},
}