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Comparative tissue distribution and depuration characteristics of copper nanoparticles and soluble copper in rainbow trout (Oncorhynchus mykiss)

Lindh, Stina LU (2017) KBK820 20171
Pure and Applied Biochemistry
Abstract
The continuously growing number of products containing nanoparticles makes their presence in the environment seem inevitable and given the well-known toxicity of dissolved metals, concerns regarding the toxicity of metal-based nanoparticles have been raised. Whether metal-based nanoparticles present similar or different toxicological effects compared to metal salts is a progressing field. In the present study, rainbow trout were intraperitoneally injected with CuSO4 or CuNPs to investigate tissue distribution and depuration characteristics. Fish injected with either CuSO4 or CuNPs, showed increased accumulation in the liver, kidney, gills, intestine, and carcass with no statistically significant difference between the two treatments. The... (More)
The continuously growing number of products containing nanoparticles makes their presence in the environment seem inevitable and given the well-known toxicity of dissolved metals, concerns regarding the toxicity of metal-based nanoparticles have been raised. Whether metal-based nanoparticles present similar or different toxicological effects compared to metal salts is a progressing field. In the present study, rainbow trout were intraperitoneally injected with CuSO4 or CuNPs to investigate tissue distribution and depuration characteristics. Fish injected with either CuSO4 or CuNPs, showed increased accumulation in the liver, kidney, gills, intestine, and carcass with no statistically significant difference between the two treatments. The intestine of Cu exposed fish showed a significant reduction in Cu concentrations after 192 h. A similar trend was observed for gills and carcass, but was not statistically significant. Copper levels in the liver appeared to increase over the 192 h depuration period. In addition, rainbow trout exposed to CuNP in an aqueous exposure regime showed no significant Cu accumulation in analysed tissues. In conclusion, copper in the form of ions or NPs appear to have similar accumulation patterns after injection and do not significantly depurate from the liver, kidney, gills, and carcass after 192 h. A longer depuration period is needed to possibly detect significant effects and possible similarities and differences between depuration characteristics of soluble Cu and CuNPs. (Less)
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author
Lindh, Stina LU
supervisor
organization
course
KBK820 20171
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Copper nanoparticles, Fish, Copper accumulation, Depuration, Tissue distribution, Applied biochemistry, tillämpad biokemi
language
English
id
8926207
date added to LUP
2017-10-31 08:50:33
date last changed
2017-10-31 08:50:33
@misc{8926207,
  abstract     = {The continuously growing number of products containing nanoparticles makes their presence in the environment seem inevitable and given the well-known toxicity of dissolved metals, concerns regarding the toxicity of metal-based nanoparticles have been raised. Whether metal-based nanoparticles present similar or different toxicological effects compared to metal salts is a progressing field. In the present study, rainbow trout were intraperitoneally injected with CuSO4 or CuNPs to investigate tissue distribution and depuration characteristics. Fish injected with either CuSO4 or CuNPs, showed increased accumulation in the liver, kidney, gills, intestine, and carcass with no statistically significant difference between the two treatments. The intestine of Cu exposed fish showed a significant reduction in Cu concentrations after 192 h. A similar trend was observed for gills and carcass, but was not statistically significant. Copper levels in the liver appeared to increase over the 192 h depuration period. In addition, rainbow trout exposed to CuNP in an aqueous exposure regime showed no significant Cu accumulation in analysed tissues. In conclusion, copper in the form of ions or NPs appear to have similar accumulation patterns after injection and do not significantly depurate from the liver, kidney, gills, and carcass after 192 h. A longer depuration period is needed to possibly detect significant effects and possible similarities and differences between depuration characteristics of soluble Cu and CuNPs.},
  author       = {Lindh, Stina},
  keyword      = {Copper nanoparticles,Fish,Copper accumulation,Depuration,Tissue distribution,Applied biochemistry,tillämpad biokemi},
  language     = {eng},
  note         = {Student Paper},
  title        = {Comparative tissue distribution and depuration characteristics of copper nanoparticles and soluble copper in rainbow trout (Oncorhynchus mykiss)},
  year         = {2017},
}