Development of Vessel Phantoms for Ultrasound Methods
(2018) BMEM01 20181Department of Biomedical Engineering
- Abstract
- Phantoms mimicking the specific mechanical and acoustic properties of human tissues are essential in the development and evaluation of novel ultrasound methods. In this work, various ultrasound phantoms are proposed to be used in the development of ultrasound methods to investigate the arterial walls longitudinal movements influence on the vasa vasorum circulation.
The longitudinal movement of arteries has been shown in vivio. It has been measured to be of the same magnitude as the diameter change of the arteries. Ultrasound phantoms simulating the arterial longitudinal movement has recently been made using Polyvinyl alcohol (PVA). However, these phantoms suffered from having low temporal stability and easy degradation.
This master’s... (More) - Phantoms mimicking the specific mechanical and acoustic properties of human tissues are essential in the development and evaluation of novel ultrasound methods. In this work, various ultrasound phantoms are proposed to be used in the development of ultrasound methods to investigate the arterial walls longitudinal movements influence on the vasa vasorum circulation.
The longitudinal movement of arteries has been shown in vivio. It has been measured to be of the same magnitude as the diameter change of the arteries. Ultrasound phantoms simulating the arterial longitudinal movement has recently been made using Polyvinyl alcohol (PVA). However, these phantoms suffered from having low temporal stability and easy degradation.
This master’s thesis investigates several tissues mimicking materials and describes the design and fabrication of ultrasound phantom models that simulate the vasa vasorum (the vessels of the vessel) and the longitudinal movement of the arterial wall. The mechanical properties of phantom materials were evaluated with a mechanical test instrument and the speed of sound was measured using a method based on the time of flight, and the attenuation was also measured. We showed that copolymer-in-oil, as well as ballistic gel, are excellent alternatives for vessel phantom fabrication. The Young’s modulus for copolymer in oil and ballistic gel was measured to be 37 and 82 kPa, respectively. The attenuation coefficients were 0.83 and 0.40 dB/MHz/cm, respectively. The ultrasound speed ranged from 1433–1458 m/s.
The results suggest that the best alternative is to use the commercially available styrene-ethylene/butylene-styrene (SEBS) block copolymer in mineral oil, and the clear synthetic ballistics gelatin of 10%. A walled and multi-layered vessel phantom in a cylindrical geometry and with decreasing diameter was designed and fabricated. The longitudinal and radial movements were generated by the use of pulsatile flow produced from a gear pump. The longitudinal movement was measured to 0.2 mm and the radial movement to 0.8 mm. (Less) - Popular Abstract
- Ultrasound Phantoms Mimicking the Vessels of the Vessels
Millions of people around the world suffer and die every year due to diseases related to blood circulation. This number could be decreased significantly if better and early detection methods were developed. In order to develop advanced methods, it is important to have access to a controlled environment that mimic the phenomena of interest. Arteries are blood vessels responsible of carrying oxygenated blood from the heart out to the body and are elastic, moveable and stretchable. Since the 1970s it is known that there is an arterial diameter change, and it is what is looked for when care takers want to measure blood pressure. On the other hand, not until recently an ultrasound... (More) - Ultrasound Phantoms Mimicking the Vessels of the Vessels
Millions of people around the world suffer and die every year due to diseases related to blood circulation. This number could be decreased significantly if better and early detection methods were developed. In order to develop advanced methods, it is important to have access to a controlled environment that mimic the phenomena of interest. Arteries are blood vessels responsible of carrying oxygenated blood from the heart out to the body and are elastic, moveable and stretchable. Since the 1970s it is known that there is an arterial diameter change, and it is what is looked for when care takers want to measure blood pressure. On the other hand, not until recently an ultrasound method was developed to detect and show that the arterial wall moves in the direction of the blood flow as well. Ultrasound is a high frequency sound and images are created from the reflected sound waves by the different body structures. Ultrasound equipment is frequently used in medical diagnosis, for example on pregnant women to check their babies.
Researchers would like to develop ultrasound methods to understand how the arterial wall movements might affect the blood circulation within the micro vessels that provide blood supply and nourishment to the walls of vessels. These micro vessels are also called vasa vasorum which comes from Latin and means the vessels of the vessels and is a network of small vessels. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/8936013
- author
- Meirza, Benjamin LU
- supervisor
- organization
- course
- BMEM01 20181
- year
- 2018
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Longitudinal movement of the arterial wall, Vasa vasourom, Micro vessles, SEBS, Ultrasound phantom.
- language
- English
- additional info
- 2018-05
- id
- 8936013
- date added to LUP
- 2018-02-23 14:38:58
- date last changed
- 2018-02-23 14:49:23
@misc{8936013,
abstract = {{Phantoms mimicking the specific mechanical and acoustic properties of human tissues are essential in the development and evaluation of novel ultrasound methods. In this work, various ultrasound phantoms are proposed to be used in the development of ultrasound methods to investigate the arterial walls longitudinal movements influence on the vasa vasorum circulation.
The longitudinal movement of arteries has been shown in vivio. It has been measured to be of the same magnitude as the diameter change of the arteries. Ultrasound phantoms simulating the arterial longitudinal movement has recently been made using Polyvinyl alcohol (PVA). However, these phantoms suffered from having low temporal stability and easy degradation.
This master’s thesis investigates several tissues mimicking materials and describes the design and fabrication of ultrasound phantom models that simulate the vasa vasorum (the vessels of the vessel) and the longitudinal movement of the arterial wall. The mechanical properties of phantom materials were evaluated with a mechanical test instrument and the speed of sound was measured using a method based on the time of flight, and the attenuation was also measured. We showed that copolymer-in-oil, as well as ballistic gel, are excellent alternatives for vessel phantom fabrication. The Young’s modulus for copolymer in oil and ballistic gel was measured to be 37 and 82 kPa, respectively. The attenuation coefficients were 0.83 and 0.40 dB/MHz/cm, respectively. The ultrasound speed ranged from 1433–1458 m/s.
The results suggest that the best alternative is to use the commercially available styrene-ethylene/butylene-styrene (SEBS) block copolymer in mineral oil, and the clear synthetic ballistics gelatin of 10%. A walled and multi-layered vessel phantom in a cylindrical geometry and with decreasing diameter was designed and fabricated. The longitudinal and radial movements were generated by the use of pulsatile flow produced from a gear pump. The longitudinal movement was measured to 0.2 mm and the radial movement to 0.8 mm.}},
author = {{Meirza, Benjamin}},
language = {{eng}},
note = {{Student Paper}},
title = {{Development of Vessel Phantoms for Ultrasound Methods}},
year = {{2018}},
}