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Tinnitus as a Symptom of Cochlear Synaptopathy? A Study of Auditory Brainstem Responses

Redgård, Rickard LU (2018) AUDM81 20181
Logopedics, Phoniatrics and Audiology
Abstract (Swedish)
Purpose. The purpose of the present study is to study the relationship between cochlear synaptopathy and tinnitus. Method. 29 participants with and without tinnitus were tested for hearing, including speech in noise and electrocochleography. Extracted data were then merged with existing data of 423 participants from the STOP cohort. These were divided into cases, with either permanent or occasional bilateral tinnitus, and controls. Participants with impaired hearing were excluded from analysis. The data were analysed for intergroup differences on amplitude and latency for all ABR waves, as well as speech in noise performance. Results. A trend in lower wave I amplitude was observed in the occasional tinnitus group. The permanent tinnitus... (More)
Purpose. The purpose of the present study is to study the relationship between cochlear synaptopathy and tinnitus. Method. 29 participants with and without tinnitus were tested for hearing, including speech in noise and electrocochleography. Extracted data were then merged with existing data of 423 participants from the STOP cohort. These were divided into cases, with either permanent or occasional bilateral tinnitus, and controls. Participants with impaired hearing were excluded from analysis. The data were analysed for intergroup differences on amplitude and latency for all ABR waves, as well as speech in noise performance. Results. A trend in lower wave I amplitude was observed in the occasional tinnitus group. The permanent tinnitus group had lower wave V amplitude than controls. Latencies for waves II through V were greater in the permanent tinnitus group compared to both occasional tinnitus and control groups. Conclusions. The study confirms latency findings of previous studies but finds no support for cochlear synaptopathy. Results suggest that occasional and permanent tinnitus are different subtypes of tinnitus, with different physiological correlates and underlying mechanisms. Further studies with larger sample sizes are needed to better differentiate tinnitus subtypes and to confirm the benefit of studying high-frequency thresholds (> 8 kHz). (Less)
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author
Redgård, Rickard LU
supervisor
organization
course
AUDM81 20181
year
type
H1 - Master's Degree (One Year)
subject
keywords
tinnitus, electrocochleography, ABR, synaptopathy
language
English
id
8951812
date added to LUP
2018-06-20 15:14:18
date last changed
2018-06-20 15:14:18
@misc{8951812,
  abstract     = {Purpose. The purpose of the present study is to study the relationship between cochlear synaptopathy and tinnitus. Method. 29 participants with and without tinnitus were tested for hearing, including speech in noise and electrocochleography. Extracted data were then merged with existing data of 423 participants from the STOP cohort. These were divided into cases, with either permanent or occasional bilateral tinnitus, and controls. Participants with impaired hearing were excluded from analysis. The data were analysed for intergroup differences on amplitude and latency for all ABR waves, as well as speech in noise performance. Results. A trend in lower wave I amplitude was observed in the occasional tinnitus group. The permanent tinnitus group had lower wave V amplitude than controls. Latencies for waves II through V were greater in the permanent tinnitus group compared to both occasional tinnitus and control groups. Conclusions. The study confirms latency findings of previous studies but finds no support for cochlear synaptopathy. Results suggest that occasional and permanent tinnitus are different subtypes of tinnitus, with different physiological correlates and underlying mechanisms. Further studies with larger sample sizes are needed to better differentiate tinnitus subtypes and to confirm the benefit of studying high-frequency thresholds (> 8 kHz).},
  author       = {Redgård, Rickard},
  keyword      = {tinnitus,electrocochleography,ABR,synaptopathy},
  language     = {eng},
  note         = {Student Paper},
  title        = {Tinnitus as a Symptom of Cochlear Synaptopathy? A Study of Auditory Brainstem Responses},
  year         = {2018},
}