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Towards the construction of a multivalent protein scaffold for influenza antigen display

Meijer, Niels (2020) MOBN02 20192
Degree Projects in Molecular Biology
Popular Abstract
Influenza is the causative agent of the flu. Symptoms usually include fever, coughing, and general malaise. Besides the general societal burden, influenza can also threaten global health when mixing its genome with influenza viruses in birds or pigs, as exemplified by the 1918 Spanish flu pandemic. The virus uses its proteins haemagglutinin (HA) and neuraminidase (NA) to get in or away from host cells, respectively. Luckily, immunising against these proteins can confer protective immunity against the strains active that year. The aim of this project is to develop a better influenza vaccine by creating a protein sheet bearing many copies of. The hypothesis is that the immune system will respond much stronger to so many foreign proteins... (More)
Influenza is the causative agent of the flu. Symptoms usually include fever, coughing, and general malaise. Besides the general societal burden, influenza can also threaten global health when mixing its genome with influenza viruses in birds or pigs, as exemplified by the 1918 Spanish flu pandemic. The virus uses its proteins haemagglutinin (HA) and neuraminidase (NA) to get in or away from host cells, respectively. Luckily, immunising against these proteins can confer protective immunity against the strains active that year. The aim of this project is to develop a better influenza vaccine by creating a protein sheet bearing many copies of. The hypothesis is that the immune system will respond much stronger to so many foreign proteins linked together, compared to the same number of proteins individually. This linkage will be achieved by designing a polymerising protein lattice that can have HA attached in its proper polymerisation form on both sides. The sequence of the scaffold will be designed de novo by computational means, using the Rosetta software suite. In the end a real protein with this sequence was to be synthesised and tested for the desired properties. (Less)
Please use this url to cite or link to this publication:
author
Meijer, Niels
supervisor
organization
course
MOBN02 20192
year
type
H2 - Master's Degree (Two Years)
subject
language
English
id
9029317
date added to LUP
2020-09-15 11:30:39
date last changed
2020-09-15 11:30:39
@misc{9029317,
  author       = {{Meijer, Niels}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Towards the construction of a multivalent protein scaffold for influenza antigen display}},
  year         = {{2020}},
}