Skip to main content

LUP Student Papers

LUND UNIVERSITY LIBRARIES

Development of a post-processing pipeline for Myelin Water Imaging at 7 T

Clemensson, Petter LU and Berthold, Elliot LU (2022) In Proceedings of Clinical Innovations 2022 EEML05 20221
Department of Biomedical Engineering
Abstract
Myelin water imaging, MWI, is a non-invasive method used for quantifying the amount of myelin in the brain that can aid the understanding of brain plasticity and neurodegenerative diseases, such as Multiple Sclerosis (MS). Conventional MWI is done at a field strength of 3 T, though there are indications that higher field strength may lead to higher resolution images. We investigate the use of isotropic voxels and echo time (TE) 8 ms at 7 T MWI, establish favorable parameters, and compare our results with a previous study, where anisotropic voxels and TE 10 ms were used. Moreover, we aim to demonstrate the usefulness of MWI at 7 T and further develop it by looking at a pilot data set consisting of diagnosed MS patients and comparing our... (More)
Myelin water imaging, MWI, is a non-invasive method used for quantifying the amount of myelin in the brain that can aid the understanding of brain plasticity and neurodegenerative diseases, such as Multiple Sclerosis (MS). Conventional MWI is done at a field strength of 3 T, though there are indications that higher field strength may lead to higher resolution images. We investigate the use of isotropic voxels and echo time (TE) 8 ms at 7 T MWI, establish favorable parameters, and compare our results with a previous study, where anisotropic voxels and TE 10 ms were used. Moreover, we aim to demonstrate the usefulness of MWI at 7 T and further develop it by looking at a pilot data set consisting of diagnosed MS patients and comparing our results to an extensive 3 T MWI atlas. Healthy individuals were scanned using 8 ms and 10 ms TE, along with a pilot dataset consisting of scans from MS patients using 8 ms TE at 7 T. We have demonstrated that MWI on 7 T scans with isotropic voxels and an 8 ms TE can be used to identify lesions associated with MS. Although 8 ms TE performed equally well as the established 10 ms TE when it comes to the characterization of the myelin water fraction, there is not enough evidence to validate that an 8 ms TE is superior to 10 ms. Further research is warranted to evaluate the possibility of generalizing the 3 T MWI atlas across field strengths. (Less)
Please use this url to cite or link to this publication:
author
Clemensson, Petter LU and Berthold, Elliot LU
supervisor
organization
course
EEML05 20221
year
type
M2 - Bachelor Degree
subject
keywords
Magnetic Resonance Imaging, Myelin Water Imaging, Neuroimaging
publication/series
Proceedings of Clinical Innovations 2022
language
English
id
9089946
date added to LUP
2022-06-30 13:36:43
date last changed
2022-06-30 13:36:43
@misc{9089946,
  abstract     = {{Myelin water imaging, MWI, is a non-invasive method used for quantifying the amount of myelin in the brain that can aid the understanding of brain plasticity and neurodegenerative diseases, such as Multiple Sclerosis (MS). Conventional MWI is done at a field strength of 3 T, though there are indications that higher field strength may lead to higher resolution images. We investigate the use of isotropic voxels and echo time (TE) 8 ms at 7 T MWI, establish favorable parameters, and compare our results with a previous study, where anisotropic voxels and TE 10 ms were used. Moreover, we aim to demonstrate the usefulness of MWI at 7 T and further develop it by looking at a pilot data set consisting of diagnosed MS patients and comparing our results to an extensive 3 T MWI atlas. Healthy individuals were scanned using 8 ms and 10 ms TE, along with a pilot dataset consisting of scans from MS patients using 8 ms TE at 7 T. We have demonstrated that MWI on 7 T scans with isotropic voxels and an 8 ms TE can be used to identify lesions associated with MS. Although 8 ms TE performed equally well as the established 10 ms TE when it comes to the characterization of the myelin water fraction, there is not enough evidence to validate that an 8 ms TE is superior to 10 ms. Further research is warranted to evaluate the possibility of generalizing the 3 T MWI atlas across field strengths.}},
  author       = {{Clemensson, Petter and Berthold, Elliot}},
  language     = {{eng}},
  note         = {{Student Paper}},
  series       = {{Proceedings of Clinical Innovations 2022}},
  title        = {{Development of a post-processing pipeline for Myelin Water Imaging at 7 T}},
  year         = {{2022}},
}