Korrelation som förbättrad detektionsmetod vid magnetomotoriskt ultraljud
(2022) EEML05 20221Department of Biomedical Engineering
- Abstract
- This report discusses the use of magnetomotive ultrasound (MMUS) as a diagnostic imaging method using superparamagnetic iron oxide nanoparticles (SPION) as a contrast agent. With a focus on rectal cancer. Rectal cancer is a disease which complications often affect the quality of life to a large extent for the affected. The principle of MMUS is based on applying a time-varying magnetic field that exerts a magnetic force on the nanoparticles injected in a chosen tissue. This vibration signature from the tissue can be detected with ultrasound.
Nowadays, phase shift is used as an imaging method, but due to its limitations, the report examines the possibility of using cross-correlation as an imaging technique instead. This is done in... (More) - This report discusses the use of magnetomotive ultrasound (MMUS) as a diagnostic imaging method using superparamagnetic iron oxide nanoparticles (SPION) as a contrast agent. With a focus on rectal cancer. Rectal cancer is a disease which complications often affect the quality of life to a large extent for the affected. The principle of MMUS is based on applying a time-varying magnetic field that exerts a magnetic force on the nanoparticles injected in a chosen tissue. This vibration signature from the tissue can be detected with ultrasound.
Nowadays, phase shift is used as an imaging method, but due to its limitations, the report examines the possibility of using cross-correlation as an imaging technique instead. This is done in collaboration with the company NanoEcho AB, which works to develop a commercial product that uses magnetomotive ultrasound (MMUS) to diagnose rectal cancer, primarily. If it is successful, the method might have other applications such as to diagnose prostate cancer. The work is done at Lund University with phantom data that NanoEcho AB has produced.
By modifying a similar software program, the phantom data has been analyzed using cross-correlation instead of phase shift. Two images have been produced where one shows high cross-correlation with the rotational frequency of the magnetic field and the other shows low, close to zero, cross-correlation with the rotational frequency of the magnetic field.
The results show that cross-correlation can be used to visualize areas with magnetic nanoparticles (SPIONS) and that the problems with the level of detail displayed during phase shifts can also be reduced, but that further research is needed in the area to draw concrete conclusions about this. Given the clear cross-correlation signal that could be measured, it is possible that more advanced signal processing can amplify the signal and thus increase the quality of the diagnostic image. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9093107
- author
- Myrén, Jonathan LU and Thiringer, Erik LU
- supervisor
- organization
- alternative title
- Correlation as an improved detection method in magnetomotive ultrasound
- course
- EEML05 20221
- year
- 2022
- type
- M2 - Bachelor Degree
- subject
- language
- Swedish
- id
- 9093107
- date added to LUP
- 2022-06-30 13:25:53
- date last changed
- 2022-06-30 13:25:53
@misc{9093107,
abstract = {{This report discusses the use of magnetomotive ultrasound (MMUS) as a diagnostic imaging method using superparamagnetic iron oxide nanoparticles (SPION) as a contrast agent. With a focus on rectal cancer. Rectal cancer is a disease which complications often affect the quality of life to a large extent for the affected. The principle of MMUS is based on applying a time-varying magnetic field that exerts a magnetic force on the nanoparticles injected in a chosen tissue. This vibration signature from the tissue can be detected with ultrasound.
Nowadays, phase shift is used as an imaging method, but due to its limitations, the report examines the possibility of using cross-correlation as an imaging technique instead. This is done in collaboration with the company NanoEcho AB, which works to develop a commercial product that uses magnetomotive ultrasound (MMUS) to diagnose rectal cancer, primarily. If it is successful, the method might have other applications such as to diagnose prostate cancer. The work is done at Lund University with phantom data that NanoEcho AB has produced.
By modifying a similar software program, the phantom data has been analyzed using cross-correlation instead of phase shift. Two images have been produced where one shows high cross-correlation with the rotational frequency of the magnetic field and the other shows low, close to zero, cross-correlation with the rotational frequency of the magnetic field.
The results show that cross-correlation can be used to visualize areas with magnetic nanoparticles (SPIONS) and that the problems with the level of detail displayed during phase shifts can also be reduced, but that further research is needed in the area to draw concrete conclusions about this. Given the clear cross-correlation signal that could be measured, it is possible that more advanced signal processing can amplify the signal and thus increase the quality of the diagnostic image.}},
author = {{Myrén, Jonathan and Thiringer, Erik}},
language = {{swe}},
note = {{Student Paper}},
title = {{Korrelation som förbättrad detektionsmetod vid magnetomotoriskt ultraljud}},
year = {{2022}},
}