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Continuous health monitoring via sampling of metabolites released through the skin

Kocalp, William LU (2022) KASM01 20221
Centre for Analysis and Synthesis
Abstract
Introduction
Skin metabolomics may serve as a powerful tool to evaluate the physiological changes oc-
curring in the body as a range of compounds, coming from inside the body, are retained
in the skin.
Background
The diffusion kinetics of metabolites across the skin, the composition of the skin, the
metabolites released as a consequence of different illnesses as well as the relationship be-
tween blood and the skin in respect to metabolism are topics within this field that are
studied. If a general profile of the skin metabolites could be constructed, it could be used
as a reference for other studies concerning the metabolism.
Aims
This project aim to answer whether certain interventions, fasting and induced sweating,
can have... (More)
Introduction
Skin metabolomics may serve as a powerful tool to evaluate the physiological changes oc-
curring in the body as a range of compounds, coming from inside the body, are retained
in the skin.
Background
The diffusion kinetics of metabolites across the skin, the composition of the skin, the
metabolites released as a consequence of different illnesses as well as the relationship be-
tween blood and the skin in respect to metabolism are topics within this field that are
studied. If a general profile of the skin metabolites could be constructed, it could be used
as a reference for other studies concerning the metabolism.
Aims
This project aim to answer whether certain interventions, fasting and induced sweating,
can have noticeable effects on the profile of skin metabolites.
Methods
To evaluate this, tape-stripping and water sampling was employed to sample the skin of
participants. The samples were analyzed using a gas chromatography–mass spectrometry
system.
Results
Around 20 metabolites were consistently identified and profiled. The extraction ratio
(MeOH/Water) of the solvent as well as the treatment of the skin did yield many sta-
tistically significant changes in the abundance of metabolites. An increased number of
tape-strips lead to an increase in abundance of metabolites. Fasting and induced sweating
did not result in a significantly observable effect for most metabolites, with the exception
of histidine and glycine.
Conclusion
Skin sampling was used to identify a list of metabolites that could serve as a profile to
describe skin metabolism. As the interventions did not yield any significantly observable
results for most metabolites, it can be said that the skin is a very rigid reservoir and it
takes more than a small intervention to cause big changes. (Less)
Please use this url to cite or link to this publication:
author
Kocalp, William LU
supervisor
organization
course
KASM01 20221
year
type
H2 - Master's Degree (Two Years)
subject
keywords
fasting, metabolism, skin, sweating, tape-stripping, technical analytical chemistry
language
English
id
9095374
date added to LUP
2022-08-01 12:09:04
date last changed
2022-08-01 12:09:04
@misc{9095374,
  abstract     = {{Introduction
Skin metabolomics may serve as a powerful tool to evaluate the physiological changes oc-
curring in the body as a range of compounds, coming from inside the body, are retained
in the skin.
Background
The diffusion kinetics of metabolites across the skin, the composition of the skin, the
metabolites released as a consequence of different illnesses as well as the relationship be-
tween blood and the skin in respect to metabolism are topics within this field that are
studied. If a general profile of the skin metabolites could be constructed, it could be used
as a reference for other studies concerning the metabolism.
Aims
This project aim to answer whether certain interventions, fasting and induced sweating,
can have noticeable effects on the profile of skin metabolites.
Methods
To evaluate this, tape-stripping and water sampling was employed to sample the skin of
participants. The samples were analyzed using a gas chromatography–mass spectrometry
system.
Results
Around 20 metabolites were consistently identified and profiled. The extraction ratio
(MeOH/Water) of the solvent as well as the treatment of the skin did yield many sta-
tistically significant changes in the abundance of metabolites. An increased number of
tape-strips lead to an increase in abundance of metabolites. Fasting and induced sweating
did not result in a significantly observable effect for most metabolites, with the exception
of histidine and glycine.
Conclusion
Skin sampling was used to identify a list of metabolites that could serve as a profile to
describe skin metabolism. As the interventions did not yield any significantly observable
results for most metabolites, it can be said that the skin is a very rigid reservoir and it
takes more than a small intervention to cause big changes.}},
  author       = {{Kocalp, William}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Continuous health monitoring via sampling of metabolites released through the skin}},
  year         = {{2022}},
}