Continuous health monitoring via sampling of metabolites released through the skin
(2022) KASM01 20221Centre for Analysis and Synthesis
- Abstract
- Introduction
Skin metabolomics may serve as a powerful tool to evaluate the physiological changes oc-
curring in the body as a range of compounds, coming from inside the body, are retained
in the skin.
Background
The diffusion kinetics of metabolites across the skin, the composition of the skin, the
metabolites released as a consequence of different illnesses as well as the relationship be-
tween blood and the skin in respect to metabolism are topics within this field that are
studied. If a general profile of the skin metabolites could be constructed, it could be used
as a reference for other studies concerning the metabolism.
Aims
This project aim to answer whether certain interventions, fasting and induced sweating,
can have... (More) - Introduction
Skin metabolomics may serve as a powerful tool to evaluate the physiological changes oc-
curring in the body as a range of compounds, coming from inside the body, are retained
in the skin.
Background
The diffusion kinetics of metabolites across the skin, the composition of the skin, the
metabolites released as a consequence of different illnesses as well as the relationship be-
tween blood and the skin in respect to metabolism are topics within this field that are
studied. If a general profile of the skin metabolites could be constructed, it could be used
as a reference for other studies concerning the metabolism.
Aims
This project aim to answer whether certain interventions, fasting and induced sweating,
can have noticeable effects on the profile of skin metabolites.
Methods
To evaluate this, tape-stripping and water sampling was employed to sample the skin of
participants. The samples were analyzed using a gas chromatography–mass spectrometry
system.
Results
Around 20 metabolites were consistently identified and profiled. The extraction ratio
(MeOH/Water) of the solvent as well as the treatment of the skin did yield many sta-
tistically significant changes in the abundance of metabolites. An increased number of
tape-strips lead to an increase in abundance of metabolites. Fasting and induced sweating
did not result in a significantly observable effect for most metabolites, with the exception
of histidine and glycine.
Conclusion
Skin sampling was used to identify a list of metabolites that could serve as a profile to
describe skin metabolism. As the interventions did not yield any significantly observable
results for most metabolites, it can be said that the skin is a very rigid reservoir and it
takes more than a small intervention to cause big changes. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9095374
- author
- Kocalp, William LU
- supervisor
-
- Oksana Rogova LU
- Peter Spégel LU
- organization
- course
- KASM01 20221
- year
- 2022
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- fasting, metabolism, skin, sweating, tape-stripping, technical analytical chemistry
- language
- English
- id
- 9095374
- date added to LUP
- 2022-08-01 12:09:04
- date last changed
- 2022-08-01 12:09:04
@misc{9095374, abstract = {{Introduction Skin metabolomics may serve as a powerful tool to evaluate the physiological changes oc- curring in the body as a range of compounds, coming from inside the body, are retained in the skin. Background The diffusion kinetics of metabolites across the skin, the composition of the skin, the metabolites released as a consequence of different illnesses as well as the relationship be- tween blood and the skin in respect to metabolism are topics within this field that are studied. If a general profile of the skin metabolites could be constructed, it could be used as a reference for other studies concerning the metabolism. Aims This project aim to answer whether certain interventions, fasting and induced sweating, can have noticeable effects on the profile of skin metabolites. Methods To evaluate this, tape-stripping and water sampling was employed to sample the skin of participants. The samples were analyzed using a gas chromatography–mass spectrometry system. Results Around 20 metabolites were consistently identified and profiled. The extraction ratio (MeOH/Water) of the solvent as well as the treatment of the skin did yield many sta- tistically significant changes in the abundance of metabolites. An increased number of tape-strips lead to an increase in abundance of metabolites. Fasting and induced sweating did not result in a significantly observable effect for most metabolites, with the exception of histidine and glycine. Conclusion Skin sampling was used to identify a list of metabolites that could serve as a profile to describe skin metabolism. As the interventions did not yield any significantly observable results for most metabolites, it can be said that the skin is a very rigid reservoir and it takes more than a small intervention to cause big changes.}}, author = {{Kocalp, William}}, language = {{eng}}, note = {{Student Paper}}, title = {{Continuous health monitoring via sampling of metabolites released through the skin}}, year = {{2022}}, }