Beyond Survival: Trajectories of neurocognitive functioning in paediatric brain tumour patients treated with surgery alone
(2023) PSPR14 20222Department of Psychology
- Abstract
- Paediatric tumour in brain and spinal cord is the second most common form of cancer in childhood. Previous research has shown inconclusive results regarding the neurocognitive outcomes of patients treated with surgery alone. The purpose of this retrospective, longitudinal study, was to explore the trajectories of neurocognitive functioning for these patients. Participants (N=107) with a paediatric brain tumour diagnosis from Skåne University Hospital were assessed one to six times with age-appropriate Weschler subtests; Vocabulary, Matrix Reasoning, Coding and Digit Span. Neurocognitive scores from assessments were analysed in separate multilevel linear models. The scores were also compared with national age adjusted norms at different... (More)
- Paediatric tumour in brain and spinal cord is the second most common form of cancer in childhood. Previous research has shown inconclusive results regarding the neurocognitive outcomes of patients treated with surgery alone. The purpose of this retrospective, longitudinal study, was to explore the trajectories of neurocognitive functioning for these patients. Participants (N=107) with a paediatric brain tumour diagnosis from Skåne University Hospital were assessed one to six times with age-appropriate Weschler subtests; Vocabulary, Matrix Reasoning, Coding and Digit Span. Neurocognitive scores from assessments were analysed in separate multilevel linear models. The scores were also compared with national age adjusted norms at different time points. Verbal comprehension was the only domain which declined in scores over time. Younger age at diagnosis was associated with poorer neurocognitive development of perceptual reasoning, and processing speed, while patients who were older at diagnosis seemed to recover within these domains post-surgery. Compared to national age norms, participants had lower scores on processing speed and working memory pre- surgery. Seizures and male sex were associated with less favourable outcomes, and further research is needed to understand the underlying biological factors in these specific risks. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9107643
- author
- Herbertsson, Amelie LU and Houghton, Evelina LU
- supervisor
- organization
- course
- PSPR14 20222
- year
- 2023
- type
- H3 - Professional qualifications (4 Years - )
- subject
- keywords
- CNS-tumor in childhood, neurocognitive outcome, surgery only
- language
- English
- id
- 9107643
- date added to LUP
- 2023-01-23 11:43:04
- date last changed
- 2023-01-23 11:43:04
@misc{9107643, abstract = {{Paediatric tumour in brain and spinal cord is the second most common form of cancer in childhood. Previous research has shown inconclusive results regarding the neurocognitive outcomes of patients treated with surgery alone. The purpose of this retrospective, longitudinal study, was to explore the trajectories of neurocognitive functioning for these patients. Participants (N=107) with a paediatric brain tumour diagnosis from Skåne University Hospital were assessed one to six times with age-appropriate Weschler subtests; Vocabulary, Matrix Reasoning, Coding and Digit Span. Neurocognitive scores from assessments were analysed in separate multilevel linear models. The scores were also compared with national age adjusted norms at different time points. Verbal comprehension was the only domain which declined in scores over time. Younger age at diagnosis was associated with poorer neurocognitive development of perceptual reasoning, and processing speed, while patients who were older at diagnosis seemed to recover within these domains post-surgery. Compared to national age norms, participants had lower scores on processing speed and working memory pre- surgery. Seizures and male sex were associated with less favourable outcomes, and further research is needed to understand the underlying biological factors in these specific risks.}}, author = {{Herbertsson, Amelie and Houghton, Evelina}}, language = {{eng}}, note = {{Student Paper}}, title = {{Beyond Survival: Trajectories of neurocognitive functioning in paediatric brain tumour patients treated with surgery alone}}, year = {{2023}}, }