Rödhåriga människors respons på smärta, analgetika och hypnotika
(2023) ANSM22 20231Department of Health Sciences
- Abstract (Swedish)
- Bakgrund och syfte: Det råder olika uppfattningar kring rödhårigas respons på smärta och behov av analgetika och hypnotika inom forskning och klinik. Forskning som studerat rödhåriga personers respons på hypnotika har visat varierande resultat där behovet har varit både ökat och minskat. Vissa menar även att rödhåriga personer har en högre smärttröskel och mindre effekt av analgetika medan andra studier talar för att rödhåriga individer tål mindre smärta och har en ökad känslighet för analgetika. Genomgående verkar responsen påverkas av melanocortin-1 receptor genen (MC1R) vilken framförallt återfinns hos rödhåriga människor. Syftet med denna studie är att sammanställa forskningen och beskriva rödhåriga människors respons av analgetika,... (More)
- Bakgrund och syfte: Det råder olika uppfattningar kring rödhårigas respons på smärta och behov av analgetika och hypnotika inom forskning och klinik. Forskning som studerat rödhåriga personers respons på hypnotika har visat varierande resultat där behovet har varit både ökat och minskat. Vissa menar även att rödhåriga personer har en högre smärttröskel och mindre effekt av analgetika medan andra studier talar för att rödhåriga individer tål mindre smärta och har en ökad känslighet för analgetika. Genomgående verkar responsen påverkas av melanocortin-1 receptor genen (MC1R) vilken framförallt återfinns hos rödhåriga människor. Syftet med denna studie är att sammanställa forskningen och beskriva rödhåriga människors respons av analgetika, hypnotika och smärta.
Metod: En systematisk litteraturöversikt baserad på resultatet av 10 vetenskapliga artiklar, granskade och analyserade med metaanalys enligt SBU:s riktlinjer.
Resultat: Ett tydligt samband mellan att vara rödhårig och bära på en mutation i MC1R har påvisats. I samtliga studier där deltagarna screenats för MC1R har en signifikant skillnad på responsen av smärta, hypnotika och analgetika påvisats. Även i andra studier utan MC1R-screening har signifikanta skillnader i responsen hos rödhåriga framkommit. (Less) - Abstract
- Background and purpose: There are different perceptions about redheads' response to pain and their need of analgesics and hypnotics, both within research and clinical practice. Research that has studied redheads’ response to hypnotics has shown varying results where the need of such both has increased and decreased. Some people go as far as to say that redheads have a higher pain threshold and a lesser effect of analgesics while still other studies found that redheads actually have a lower tolerance to pain and a higher sensitivity to analgesics. Through and through it seems that the response is impacted by the melanocortin-1 receptor gene (MC1R), mainly found in redheads. The aim of this study is to compile research and describe redheads'... (More)
- Background and purpose: There are different perceptions about redheads' response to pain and their need of analgesics and hypnotics, both within research and clinical practice. Research that has studied redheads’ response to hypnotics has shown varying results where the need of such both has increased and decreased. Some people go as far as to say that redheads have a higher pain threshold and a lesser effect of analgesics while still other studies found that redheads actually have a lower tolerance to pain and a higher sensitivity to analgesics. Through and through it seems that the response is impacted by the melanocortin-1 receptor gene (MC1R), mainly found in redheads. The aim of this study is to compile research and describe redheads' response to analgesics, hypnotics and perceived pain.
Method: A systematic literature review based on the results of ten scientific articles, reviewed and analyzed with meta-analysis according to the SBU guidelines.
Result: A significant connection between being a redhead and carrier of a mutation within the MC1R gene was demonstrated. In all the cases where the participants were screened for MC1R, a significant difference in response to pain, hypnotics, and analgesics was demonstrated. Even in studies without MC1R screening a significant difference in the response was noted. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9116742
- author
- Almqvist, Martina LU and Franze, Elisabeth
- supervisor
- organization
- alternative title
- Myter eller sanningar?
- course
- ANSM22 20231
- year
- 2023
- type
- H1 - Master's Degree (One Year)
- subject
- keywords
- Melanocortin-1 receptor, rödhåriga, hypnotika, analgetika, smärta, respons
- language
- Swedish
- id
- 9116742
- date added to LUP
- 2024-03-06 08:32:58
- date last changed
- 2024-03-06 08:32:58
@misc{9116742,
abstract = {{Background and purpose: There are different perceptions about redheads' response to pain and their need of analgesics and hypnotics, both within research and clinical practice. Research that has studied redheads’ response to hypnotics has shown varying results where the need of such both has increased and decreased. Some people go as far as to say that redheads have a higher pain threshold and a lesser effect of analgesics while still other studies found that redheads actually have a lower tolerance to pain and a higher sensitivity to analgesics. Through and through it seems that the response is impacted by the melanocortin-1 receptor gene (MC1R), mainly found in redheads. The aim of this study is to compile research and describe redheads' response to analgesics, hypnotics and perceived pain.
Method: A systematic literature review based on the results of ten scientific articles, reviewed and analyzed with meta-analysis according to the SBU guidelines.
Result: A significant connection between being a redhead and carrier of a mutation within the MC1R gene was demonstrated. In all the cases where the participants were screened for MC1R, a significant difference in response to pain, hypnotics, and analgesics was demonstrated. Even in studies without MC1R screening a significant difference in the response was noted.}},
author = {{Almqvist, Martina and Franze, Elisabeth}},
language = {{swe}},
note = {{Student Paper}},
title = {{Rödhåriga människors respons på smärta, analgetika och hypnotika}},
year = {{2023}},
}