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Role of FUT8 in the regulation of cellular signaling in ovarian cancer

Akbari Asl, Elham (2023) MOBN02 20231
Degree Projects in Molecular Biology
Popular Abstract
One of the most common cancers in women

Ovarian cancer is a major health issue and a leading cause of cancer-related deaths among women globally. A key factor in progression of ovarian cancer is a process called glycosylation, where sugars are added to proteins, altering their function. This process involves an enzyme named FUT8, which is crucial for adding specific sugar molecules to proteins. In this study, we focused on the role of FUT8 in ovarian cancer. We examined various ovarian cancer cell lines and found differences in the levels of FUT8. Some cell lines had high levels of FUT8, while others had low or undetectable levels. The study then specifically altered the amount of FUT8 in two types of ovarian cancer cells - increasing... (More)
One of the most common cancers in women

Ovarian cancer is a major health issue and a leading cause of cancer-related deaths among women globally. A key factor in progression of ovarian cancer is a process called glycosylation, where sugars are added to proteins, altering their function. This process involves an enzyme named FUT8, which is crucial for adding specific sugar molecules to proteins. In this study, we focused on the role of FUT8 in ovarian cancer. We examined various ovarian cancer cell lines and found differences in the levels of FUT8. Some cell lines had high levels of FUT8, while others had low or undetectable levels. The study then specifically altered the amount of FUT8 in two types of ovarian cancer cells - increasing it in one and decreasing it in the other.

The results were intriguing. Reducing FUT8 levels led to a slight decrease in cell growth and the ability of the cancer cells to heal after injury. Moreover, we observed that lowering FUT8 levels also decreased the overall amount of various proteins in the cells. However, it interestingly increased the activity of certain important proteins involved in cell signaling, including AXL, Insulin Receptor, and ErB3.

The study's findings highlight FUT8's significant role in ovarian cancer. By affecting the levels of various proteins and their activity, FUT8 could be a key player in cancer progression. This research opens up new possibilities for targeted ovarian cancer treatments, focusing on manipulating FUT8 levels to control the disease.

Master’s Degree Project in Molecular Biology, MOBN02, 45 credits, 2023/2023
Department of Biology, Lund University


Supervisor: Kazi Julhash Uddin
Co-supervisor: Ahmad Nasimian
Department of Laboratory Medicine, Lund University (Less)
Please use this url to cite or link to this publication:
author
Akbari Asl, Elham
supervisor
organization
course
MOBN02 20231
year
type
H2 - Master's Degree (Two Years)
subject
language
English
id
9143430
date added to LUP
2024-01-03 10:56:29
date last changed
2024-01-03 10:56:29
@misc{9143430,
  author       = {{Akbari Asl, Elham}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Role of FUT8 in the regulation of cellular signaling in ovarian cancer}},
  year         = {{2023}},
}