Ultra high frequency ultrasound for diagnosing Hirschsprung’s disease
(2024) EEML05 20241Department of Biomedical Engineering
- Abstract (Swedish)
- A study investigating methods of ultrasound imaging for detection and treatment of Hirschsprung's disease. Hirschsprung's disease is characterized by the absence of ganglia cells in the colon and rectum. The diagnosis today consists of x-ray and biopsies from the bowel wall. The affected part of the bowel needs to be surgically removed to allow normal bowel function. During the surgery biopsies are needed to confirm healthy bowel to know the length of bowel that needs to be resected. Previous research has proven that ultra high frequency ultrasound can be used to distinguish between aganglionic and ganglionic tissue in Hirschsprung's disease by comparing the thickness ratio between the muscularis interna (MI) and the muscularis externa... (More)
- A study investigating methods of ultrasound imaging for detection and treatment of Hirschsprung's disease. Hirschsprung's disease is characterized by the absence of ganglia cells in the colon and rectum. The diagnosis today consists of x-ray and biopsies from the bowel wall. The affected part of the bowel needs to be surgically removed to allow normal bowel function. During the surgery biopsies are needed to confirm healthy bowel to know the length of bowel that needs to be resected. Previous research has proven that ultra high frequency ultrasound can be used to distinguish between aganglionic and ganglionic tissue in Hirschsprung's disease by comparing the thickness ratio between the muscularis interna (MI) and the muscularis externa (ME). From histopathological samples the muscle layer ratio in aganglionic tissue is expected to be around 50\% lower than the ratio in ganglionic tissue.
Ultrasound images captured from the mucosal side of the bowel as well as the serosal side were compared. Images were compiled from both sides of the bowel including longitudinal and transversal orientations from aganglionic and ganglionic bowel. Intravascular ultrasound (IVUS) images were also analyzed.
A significant difference in thickness ratio MI/ME was found in linear mucosal ultrasound images. The difference in ratio MI/ME between aganglionic and ganglionic tissue was around 50\% in mucosal images which is more in line with previous histopathological findings compared to serosal images that had a lower difference. These findings indicates that mucosal images can be used to diagnose Hirschsprung's disease. No correlation between amplitude ratio and sick versus healthy bowel could be found in any of the images. No statistical conclusions could be made for the IVUS images due to limited data. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9158270
- author
- Nilsson, Julia LU and Dierschke Passikhani, Elisabeth LU
- supervisor
-
- Maria Evertsson LU
- Tobias Erlöv LU
- organization
- alternative title
- Ultrahögfrekvent ultraljud för diagnostisering av Hirschsprungs sjukdom
- course
- EEML05 20241
- year
- 2024
- type
- M2 - Bachelor Degree
- subject
- language
- English
- id
- 9158270
- date added to LUP
- 2024-06-20 13:01:18
- date last changed
- 2024-06-20 13:01:21
@misc{9158270,
abstract = {{A study investigating methods of ultrasound imaging for detection and treatment of Hirschsprung's disease. Hirschsprung's disease is characterized by the absence of ganglia cells in the colon and rectum. The diagnosis today consists of x-ray and biopsies from the bowel wall. The affected part of the bowel needs to be surgically removed to allow normal bowel function. During the surgery biopsies are needed to confirm healthy bowel to know the length of bowel that needs to be resected. Previous research has proven that ultra high frequency ultrasound can be used to distinguish between aganglionic and ganglionic tissue in Hirschsprung's disease by comparing the thickness ratio between the muscularis interna (MI) and the muscularis externa (ME). From histopathological samples the muscle layer ratio in aganglionic tissue is expected to be around 50\% lower than the ratio in ganglionic tissue.
Ultrasound images captured from the mucosal side of the bowel as well as the serosal side were compared. Images were compiled from both sides of the bowel including longitudinal and transversal orientations from aganglionic and ganglionic bowel. Intravascular ultrasound (IVUS) images were also analyzed.
A significant difference in thickness ratio MI/ME was found in linear mucosal ultrasound images. The difference in ratio MI/ME between aganglionic and ganglionic tissue was around 50\% in mucosal images which is more in line with previous histopathological findings compared to serosal images that had a lower difference. These findings indicates that mucosal images can be used to diagnose Hirschsprung's disease. No correlation between amplitude ratio and sick versus healthy bowel could be found in any of the images. No statistical conclusions could be made for the IVUS images due to limited data.}},
author = {{Nilsson, Julia and Dierschke Passikhani, Elisabeth}},
language = {{eng}},
note = {{Student Paper}},
title = {{Ultra high frequency ultrasound for diagnosing Hirschsprung’s disease}},
year = {{2024}},
}