Akustisk pack-bed. Infångning av partiklar i nanoskalan
(2024) BMEM01 20242Department of Biomedical Engineering
- Abstract
- In this master thesis a novel way of trapping nanosized particles were
tested. The technology used was based on acoustic trapping with seed
particles. In difference to earlier devices the seed particles were held in
place by a physical barrier that worked like a filter, stopping the bigger
seed particles while allowing the nanosized particles to flow through, a
setup that allowed for significantly more seed particles to be used.
The goal is that this technology could be used in the future to trap
extracellular vesicles for use in disease diagnostics. This would allow for
faster detection of various diseases and illnesses including potentially
cancers.
Trapping was successfully demonstrated with fluorescence polystyrene
... (More) - In this master thesis a novel way of trapping nanosized particles were
tested. The technology used was based on acoustic trapping with seed
particles. In difference to earlier devices the seed particles were held in
place by a physical barrier that worked like a filter, stopping the bigger
seed particles while allowing the nanosized particles to flow through, a
setup that allowed for significantly more seed particles to be used.
The goal is that this technology could be used in the future to trap
extracellular vesicles for use in disease diagnostics. This would allow for
faster detection of various diseases and illnesses including potentially
cancers.
Trapping was successfully demonstrated with fluorescence polystyrene
particles in sizes 270nm-1900nm. The fluorescence was used to track the
particles and analyze the results.
A series of experiment were also made to analyze the effect different
factors had on the trapping efficiency, including both factors related to the
device design and factors related to the experiment protocol such as the
flowrate used.
Devices were made both from glass capillaries (as is traditionally used)
and with a 3D printed plastic. Both types were shown to be functional.
Finally, an aging effect were noted as the characteristics of a device
changed over time as the device were used. A way to use this phenomenon
to optimize trapping efficiency, called priming, were suggested and
successfully demonstrated. (Less) - Popular Abstract (Swedish)
- Pack-bed framtidens medicintekniska diagnostik?
Kroppens celler kommunicerar genom att skicka information till varandra via små partiklar. Genom att fånga in dessa kan man ta del av denna information och olika sjukdomar kan därigenom detekteras. I detta arbete undersöks Pack-bed, en ny teknik där akustik används för sådan infångning.
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9178868
- author
- Bondesson, Ted LU
- supervisor
- organization
- alternative title
- Acoustic pac-bed. Trapping of nanosized particles
- course
- BMEM01 20242
- year
- 2024
- type
- H2 - Master's Degree (Two Years)
- subject
- language
- Swedish
- additional info
- 2024-24
- id
- 9178868
- date added to LUP
- 2025-01-29 14:07:54
- date last changed
- 2025-01-29 14:07:54
@misc{9178868,
abstract = {{In this master thesis a novel way of trapping nanosized particles were
tested. The technology used was based on acoustic trapping with seed
particles. In difference to earlier devices the seed particles were held in
place by a physical barrier that worked like a filter, stopping the bigger
seed particles while allowing the nanosized particles to flow through, a
setup that allowed for significantly more seed particles to be used.
The goal is that this technology could be used in the future to trap
extracellular vesicles for use in disease diagnostics. This would allow for
faster detection of various diseases and illnesses including potentially
cancers.
Trapping was successfully demonstrated with fluorescence polystyrene
particles in sizes 270nm-1900nm. The fluorescence was used to track the
particles and analyze the results.
A series of experiment were also made to analyze the effect different
factors had on the trapping efficiency, including both factors related to the
device design and factors related to the experiment protocol such as the
flowrate used.
Devices were made both from glass capillaries (as is traditionally used)
and with a 3D printed plastic. Both types were shown to be functional.
Finally, an aging effect were noted as the characteristics of a device
changed over time as the device were used. A way to use this phenomenon
to optimize trapping efficiency, called priming, were suggested and
successfully demonstrated.}},
author = {{Bondesson, Ted}},
language = {{swe}},
note = {{Student Paper}},
title = {{Akustisk pack-bed. Infångning av partiklar i nanoskalan}},
year = {{2024}},
}