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The Effect of Psilocybin-Assisted Therapy on Quality of Life: A Systematic Review and Meta-Analysis

Joneborg, Isak LU (2025) PSPR14 20242
Department of Psychology
Abstract
Background: Psilocybin-assisted therapy (PAT) shows promise in the treatment of a variety of mental disorders. To date, no meta-analysis has been conducted on the effect of PAT on quality of life (QOL). Methods: A systematic review and meta-analysis of clinical trials examining PAT and reporting on QOL, extracted from Embase, Medline, PsycInfo, Web of Science and Cochrane CENTRAL. Results: Across six studies (pooled n = 412), the effect of PAT on QOL was moderate to large (g = 0.69). Pre-post within-group effect was large (g = 1.08), pre- to follow-up within-group effect was moderate (g = 0.61) and pre-post between-group effect was small (g = 0.31). Limitations: Few studies available, low sample sizes, and high risk of bias. Conclusion:... (More)
Background: Psilocybin-assisted therapy (PAT) shows promise in the treatment of a variety of mental disorders. To date, no meta-analysis has been conducted on the effect of PAT on quality of life (QOL). Methods: A systematic review and meta-analysis of clinical trials examining PAT and reporting on QOL, extracted from Embase, Medline, PsycInfo, Web of Science and Cochrane CENTRAL. Results: Across six studies (pooled n = 412), the effect of PAT on QOL was moderate to large (g = 0.69). Pre-post within-group effect was large (g = 1.08), pre- to follow-up within-group effect was moderate (g = 0.61) and pre-post between-group effect was small (g = 0.31). Limitations: Few studies available, low sample sizes, and high risk of bias. Conclusion: Our review and meta-analysis suggest that PAT may be effective in increasing QOL across a clinically diverse sample, however caution is warranted due to various limitations. (Less)
Please use this url to cite or link to this publication:
author
Joneborg, Isak LU
supervisor
organization
course
PSPR14 20242
year
type
H3 - Professional qualifications (4 Years - )
subject
keywords
Psychedelic-assisted therapy, quality of life, rapid-acting antidepressants, mood disorders, illness-related distress
language
English
id
9184606
date added to LUP
2025-02-10 12:40:07
date last changed
2025-02-10 12:40:07
@misc{9184606,
  abstract     = {{Background: Psilocybin-assisted therapy (PAT) shows promise in the treatment of a variety of mental disorders. To date, no meta-analysis has been conducted on the effect of PAT on quality of life (QOL). Methods: A systematic review and meta-analysis of clinical trials examining PAT and reporting on QOL, extracted from Embase, Medline, PsycInfo, Web of Science and Cochrane CENTRAL. Results: Across six studies (pooled n = 412), the effect of PAT on QOL was moderate to large (g = 0.69). Pre-post within-group effect was large (g = 1.08), pre- to follow-up within-group effect was moderate (g = 0.61) and pre-post between-group effect was small (g = 0.31). Limitations: Few studies available, low sample sizes, and high risk of bias. Conclusion: Our review and meta-analysis suggest that PAT may be effective in increasing QOL across a clinically diverse sample, however caution is warranted due to various limitations.}},
  author       = {{Joneborg, Isak}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{The Effect of Psilocybin-Assisted Therapy on Quality of Life: A Systematic Review and Meta-Analysis}},
  year         = {{2025}},
}