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Association of Traumatic Brain Injuries with Increased Risk of Malignant Brain and other CNS Tumors

Magnusson, David LU and Røysland Gudde, Niels (2024) In Master's Thesis in Mathematical Sciences FMSM01 20241
Mathematical Statistics
Abstract
This thesis investigates the association between traumatic brain injuries (TBIs) of varying severities and the subsequent risk of developing malignant brain and other central nervous system (CNS) tumors. Utilizing a retrospective study design, medical records involving 34,004 adult patients who suffered TBIs between January 2nd, 2000, and March 1st, 2023, were analyzed. The study employed survival analysis techniques, including Kaplan-Meier estimators, the Cox proportional hazard model, and semi-competing risk analysis to explore the impact of TBI severity and the administration of anti-inflammatory drugs around the time of injury on tumor development. The findings suggest a statistically significant association with a hazard ratio of 1.64... (More)
This thesis investigates the association between traumatic brain injuries (TBIs) of varying severities and the subsequent risk of developing malignant brain and other central nervous system (CNS) tumors. Utilizing a retrospective study design, medical records involving 34,004 adult patients who suffered TBIs between January 2nd, 2000, and March 1st, 2023, were analyzed. The study employed survival analysis techniques, including Kaplan-Meier estimators, the Cox proportional hazard model, and semi-competing risk analysis to explore the impact of TBI severity and the administration of anti-inflammatory drugs around the time of injury on tumor development. The findings suggest a statistically significant association with a hazard ratio of 1.64 (95% CI: 1.07, 2.50) for moderate/severe TBIs compared to the control group. Mild TBIs did not show a significant increase in risk, and the dataset contained too few cases of penetrating TBIs for any conclusions to be drawn. The role of anti-inflammatory drugs did not demonstrate a significant protective effect against tumor development.Additionally, the thesis explored potential clustering of patient characteristics and pre-existing conditions to identify subgroups with higher risks. However, this analysis did not yield definitive insights. (Less)
Please use this url to cite or link to this publication:
author
Magnusson, David LU and Røysland Gudde, Niels
supervisor
organization
course
FMSM01 20241
year
type
H2 - Master's Degree (Two Years)
subject
publication/series
Master's Thesis in Mathematical Sciences
report number
LUTFMS-33497-2024
ISSN
1404-6342
other publication id
2024:E42
language
English
id
9186579
date added to LUP
2025-03-19 14:40:25
date last changed
2025-03-19 14:40:25
@misc{9186579,
  abstract     = {{This thesis investigates the association between traumatic brain injuries (TBIs) of varying severities and the subsequent risk of developing malignant brain and other central nervous system (CNS) tumors. Utilizing a retrospective study design, medical records involving 34,004 adult patients who suffered TBIs between January 2nd, 2000, and March 1st, 2023, were analyzed. The study employed survival analysis techniques, including Kaplan-Meier estimators, the Cox proportional hazard model, and semi-competing risk analysis to explore the impact of TBI severity and the administration of anti-inflammatory drugs around the time of injury on tumor development. The findings suggest a statistically significant association with a hazard ratio of 1.64 (95% CI: 1.07, 2.50) for moderate/severe TBIs compared to the control group. Mild TBIs did not show a significant increase in risk, and the dataset contained too few cases of penetrating TBIs for any conclusions to be drawn. The role of anti-inflammatory drugs did not demonstrate a significant protective effect against tumor development.Additionally, the thesis explored potential clustering of patient characteristics and pre-existing conditions to identify subgroups with higher risks. However, this analysis did not yield definitive insights.}},
  author       = {{Magnusson, David and Røysland Gudde, Niels}},
  issn         = {{1404-6342}},
  language     = {{eng}},
  note         = {{Student Paper}},
  series       = {{Master's Thesis in Mathematical Sciences}},
  title        = {{Association of Traumatic Brain Injuries with Increased Risk of Malignant Brain and other CNS Tumors}},
  year         = {{2024}},
}