Correlation between immersion testing methods for evaluating corrosion rate in magnesium alloys
(2025) EEML05 20251Department of Biomedical Engineering
- Abstract
- A challenge when predicting physiological corrosion behaviour of biomaterials is the lack of established correlation between the results from in vitro and in vivo studies. This project investigates how the selection of immersion testing method affects the degradation of magnesium based alloys by comparing corrosion rates obtained from three methods: bioreactor, incubator and isothermal calorimetry. The methods produced significant differences in corrosion rates despite material samples and testing medium being identical. The bioreactor produced the highest corrosion rates, likely due to the flow of testing medium as well as active pH regulation. The incubator and calorimeter results were more similar, with calorimetric corrosion rates... (More)
- A challenge when predicting physiological corrosion behaviour of biomaterials is the lack of established correlation between the results from in vitro and in vivo studies. This project investigates how the selection of immersion testing method affects the degradation of magnesium based alloys by comparing corrosion rates obtained from three methods: bioreactor, incubator and isothermal calorimetry. The methods produced significant differences in corrosion rates despite material samples and testing medium being identical. The bioreactor produced the highest corrosion rates, likely due to the flow of testing medium as well as active pH regulation. The incubator and calorimeter results were more similar, with calorimetric corrosion rates derived from pressure evolution being consistently lower than the corresponding corrosion rates calculated from mass loss. The findings of the report emphasise the importance of choosing parameters that simulate the physiological environment in order to achieve reliable corrosion rates in-vitro. Although the dataset was too small to determine a definitive correlation to traditional immersion methods, the in-house built isothermal calorimeter produced reasonable measurements. This suggests that further optimization of the instrument could result in a reliable immersion method for obtaining continuous corrosion rates, along with measurements of hydrogen gas evolution. This method is relevant for further studies, as it has the potential to reduce the reliance on animal trials in early stages of biodegradable material development. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9204620
- author
- Giang, Fredrik LU and Bohman, Hanna LU
- supervisor
-
- Dmytro Orlov LU
- organization
- alternative title
- Korrelation mellan immersionsmetoder för korrosionstest av magnesiumlegeringar
- course
- EEML05 20251
- year
- 2025
- type
- M2 - Bachelor Degree
- subject
- language
- English
- id
- 9204620
- date added to LUP
- 2025-07-01 09:30:46
- date last changed
- 2025-07-01 09:30:46
@misc{9204620,
abstract = {{A challenge when predicting physiological corrosion behaviour of biomaterials is the lack of established correlation between the results from in vitro and in vivo studies. This project investigates how the selection of immersion testing method affects the degradation of magnesium based alloys by comparing corrosion rates obtained from three methods: bioreactor, incubator and isothermal calorimetry. The methods produced significant differences in corrosion rates despite material samples and testing medium being identical. The bioreactor produced the highest corrosion rates, likely due to the flow of testing medium as well as active pH regulation. The incubator and calorimeter results were more similar, with calorimetric corrosion rates derived from pressure evolution being consistently lower than the corresponding corrosion rates calculated from mass loss. The findings of the report emphasise the importance of choosing parameters that simulate the physiological environment in order to achieve reliable corrosion rates in-vitro. Although the dataset was too small to determine a definitive correlation to traditional immersion methods, the in-house built isothermal calorimeter produced reasonable measurements. This suggests that further optimization of the instrument could result in a reliable immersion method for obtaining continuous corrosion rates, along with measurements of hydrogen gas evolution. This method is relevant for further studies, as it has the potential to reduce the reliance on animal trials in early stages of biodegradable material development.}},
author = {{Giang, Fredrik and Bohman, Hanna}},
language = {{eng}},
note = {{Student Paper}},
title = {{Correlation between immersion testing methods for evaluating corrosion rate in magnesium alloys}},
year = {{2025}},
}