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Högfrekvent ultraljud för diagnosticering av Hirschsprungs sjukdom hos spädbarn

Petersson, Celine LU and Franzén, Sanna LU (2025) EEML05 20251
Department of Biomedical Engineering
Abstract
The report investigates whether ultra-high-frequency ultrasound at 30 MHz can distinguish healthy- from diseased intestinal tissue in infants with Hirschsprung's disease with the same accuracy as 50 MHz. Hirschsprung's disease is defined as the absence of ganglion cells in the distal parts of the intestine. During treatment, the affected sections of the intestine are surgically removed. The procedure requires multiple biopsies to ensure that all sections lacking ganglion cells are removed. Since biopsies are time-consuming, this report explores the possibility of using 30 MHz ultrasound instead. Previous research has shown that 50 MHz ultrasound has the potential to replace current primary diagnostic methods for Hirschsprung's disease.... (More)
The report investigates whether ultra-high-frequency ultrasound at 30 MHz can distinguish healthy- from diseased intestinal tissue in infants with Hirschsprung's disease with the same accuracy as 50 MHz. Hirschsprung's disease is defined as the absence of ganglion cells in the distal parts of the intestine. During treatment, the affected sections of the intestine are surgically removed. The procedure requires multiple biopsies to ensure that all sections lacking ganglion cells are removed. Since biopsies are time-consuming, this report explores the possibility of using 30 MHz ultrasound instead. Previous research has shown that 50 MHz ultrasound has the potential to replace current primary diagnostic methods for Hirschsprung's disease. However, 30 MHz ultrasound probes are more accessible and cost-effective compared to 50 MHz probes, making it relevant to investigate whether the lower frequency is able to achieve the same relevant results. To evaluate this, ultrasound images of both healthy and diseased intestinal tissue were analyzed using 30 MHz and 50 MHz probes to assess differences in the thickness of the different tissue layers as well as echogenicity. The results show a high degree of agreement between measurements obtained with the 30 MHz and 50 MHz probes, based on significance levels for thickness and echogenicity (brightness), as well as measurement differences. 30 MHz was proven to acheive enough resolution to distinguish the same significant differences between healthy and diseased bowel tissue as 50 MHz. (Less)
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author
Petersson, Celine LU and Franzén, Sanna LU
supervisor
organization
alternative title
High-frequency ultrasound to diagnose Hirschsprung’s disease in infants
course
EEML05 20251
year
type
M2 - Bachelor Degree
subject
language
Swedish
id
9206956
date added to LUP
2025-07-01 09:39:05
date last changed
2025-07-01 09:39:05
@misc{9206956,
  abstract     = {{The report investigates whether ultra-high-frequency ultrasound at 30 MHz can distinguish healthy- from diseased intestinal tissue in infants with Hirschsprung's disease with the same accuracy as 50 MHz. Hirschsprung's disease is defined as the absence of ganglion cells in the distal parts of the intestine. During treatment, the affected sections of the intestine are surgically removed. The procedure requires multiple biopsies to ensure that all sections lacking ganglion cells are removed. Since biopsies are time-consuming, this report explores the possibility of using 30 MHz ultrasound instead. Previous research has shown that 50 MHz ultrasound has the potential to replace current primary diagnostic methods for Hirschsprung's disease. However, 30 MHz ultrasound probes are more accessible and cost-effective compared to 50 MHz probes, making it relevant to investigate whether the lower frequency is able to achieve the same relevant results. To evaluate this, ultrasound images of both healthy and diseased intestinal tissue were analyzed using 30 MHz and 50 MHz probes to assess differences in the thickness of the different tissue layers as well as echogenicity. The results show a high degree of agreement between measurements obtained with the 30 MHz and 50 MHz probes, based on significance levels for thickness and echogenicity (brightness), as well as measurement differences. 30 MHz was proven to acheive enough resolution to distinguish the same significant differences between healthy and diseased bowel tissue as 50 MHz.}},
  author       = {{Petersson, Celine and Franzén, Sanna}},
  language     = {{swe}},
  note         = {{Student Paper}},
  title        = {{Högfrekvent ultraljud för diagnosticering av Hirschsprungs sjukdom hos spädbarn}},
  year         = {{2025}},
}