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Exponering av bisfenol A från fiskkonserver

Pham, Jen LU (2014) MVEK02 20141
Studies in Environmental Science
Abstract
Bisphenol A (BPA) is an endocrine disruptor which is very present in our surrounding environment. As a component mainly used in plastics and in the inner linings in cans, BPA can also be found in our bodies due to migration into food. Once the substance is reaching the components of the body it is biotransformed into a more water soluble molecule called monoglucoronide. Whether to measure the unconjugated BPA or the monoglucoronide in biological samples is, in the world of scientists, still debated. Many hold that only the unconjugated BPA is acting as a endocrine disruptor but contamination of BPA from materials in lab could obscure the true levels of exposure. One could try the best to avoid contamination or instead measure the levels of... (More)
Bisphenol A (BPA) is an endocrine disruptor which is very present in our surrounding environment. As a component mainly used in plastics and in the inner linings in cans, BPA can also be found in our bodies due to migration into food. Once the substance is reaching the components of the body it is biotransformed into a more water soluble molecule called monoglucoronide. Whether to measure the unconjugated BPA or the monoglucoronide in biological samples is, in the world of scientists, still debated. Many hold that only the unconjugated BPA is acting as a endocrine disruptor but contamination of BPA from materials in lab could obscure the true levels of exposure. One could try the best to avoid contamination or instead measure the levels of monoglucoronide. Both methods were conducted in this study in order to examine if there were any exposure of BPA from canned fish to humans. 21 volunteers donated urine and blood samples after having a lunch consisting of different fishes in cans. The samples were then analyzed for unconjugated BPA and monoglucoronide in urine. Solely unconjugated BPA was analyzed in blood serum by two different techniques - one with enzyme and one without. The analyses were performed by liquid chromatography-tandem mass spectrometry. The results revealed elevated levels of BPA in urine and in blood serum samples, with enzyme, several hours after lunch. Monoglucoronide in urine was partly detected when comparing with earlier analysis executed by the Occupational and Environmental Medicine at Lund University. This could be due to the present of other metabolites. Eating sardines or tuna gave a significant elevation of BPA in urine. Hence canned fish is a source of exposure of BPA to humans. This study demonstrates the ubiquitous nature of BPA in our daily life. (Less)
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author
Pham, Jen LU
supervisor
organization
course
MVEK02 20141
year
type
M2 - Bachelor Degree
subject
keywords
bisphenol A, BPA, monoglucoronide, endocrine disruptor, urine, blood serum, canned fish
language
Swedish
id
4457962
date added to LUP
2014-06-30 17:47:53
date last changed
2014-06-30 17:47:53
@misc{4457962,
  abstract     = {{Bisphenol A (BPA) is an endocrine disruptor which is very present in our surrounding environment. As a component mainly used in plastics and in the inner linings in cans, BPA can also be found in our bodies due to migration into food. Once the substance is reaching the components of the body it is biotransformed into a more water soluble molecule called monoglucoronide. Whether to measure the unconjugated BPA or the monoglucoronide in biological samples is, in the world of scientists, still debated. Many hold that only the unconjugated BPA is acting as a endocrine disruptor but contamination of BPA from materials in lab could obscure the true levels of exposure. One could try the best to avoid contamination or instead measure the levels of monoglucoronide. Both methods were conducted in this study in order to examine if there were any exposure of BPA from canned fish to humans. 21 volunteers donated urine and blood samples after having a lunch consisting of different fishes in cans. The samples were then analyzed for unconjugated BPA and monoglucoronide in urine. Solely unconjugated BPA was analyzed in blood serum by two different techniques - one with enzyme and one without. The analyses were performed by liquid chromatography-tandem mass spectrometry. The results revealed elevated levels of BPA in urine and in blood serum samples, with enzyme, several hours after lunch. Monoglucoronide in urine was partly detected when comparing with earlier analysis executed by the Occupational and Environmental Medicine at Lund University. This could be due to the present of other metabolites. Eating sardines or tuna gave a significant elevation of BPA in urine. Hence canned fish is a source of exposure of BPA to humans. This study demonstrates the ubiquitous nature of BPA in our daily life.}},
  author       = {{Pham, Jen}},
  language     = {{swe}},
  note         = {{Student Paper}},
  title        = {{Exponering av bisfenol A från fiskkonserver}},
  year         = {{2014}},
}