Minnesinterferens: Relationen mellan mönsterseparation och inhibitorisk kontroll vid bipolär sjukdom
(2014) PSPT02 20141Department of Psychology
- Abstract
- Pattern separation is a neural mechanism for creating distinct, non-overlapping, memory traces for similar inputs. Despite this, memories may overlap, and this often produces interference during retrieval of a particular target memory. To reduce interference during selective retrieval another mechanism comes into play, namely inhibition of related, competing memories. This inhibition is believed to cause “retrieval-induced forgetting” (RIF) of the competing memories, which has recurrently been demonstrated by means of the retrieval-practice paradigm. Even though pattern separation at encoding and inhibition during retrieval are both related to interference, there is a sparse understanding of their mutual relationship. In addition, there is... (More)
- Pattern separation is a neural mechanism for creating distinct, non-overlapping, memory traces for similar inputs. Despite this, memories may overlap, and this often produces interference during retrieval of a particular target memory. To reduce interference during selective retrieval another mechanism comes into play, namely inhibition of related, competing memories. This inhibition is believed to cause “retrieval-induced forgetting” (RIF) of the competing memories, which has recurrently been demonstrated by means of the retrieval-practice paradigm. Even though pattern separation at encoding and inhibition during retrieval are both related to interference, there is a sparse understanding of their mutual relationship. In addition, there is a need for further studies of these phenomena in clinical populations. In this study, 40 patients diagnosed with bipolar disorder completed a behavioral pattern separation task, as well as a retrieval-practice experiment. Four tests from the Cambridge Neuropsychological Test Automated Battery were also conducted, and patients were asked questions regarding lifestyle factors and affective symptoms. The results supported previous findings of a relationship between physical activity and pattern separation, as well as a connection between pattern separation and selective serotonin reuptake inhibitors. In accordance with previous studies on clinical populations, no RIF effect was found for the group as a whole. However, when divided according to pattern separation ability, significant RIF was found for patients with low such ability, whereas no such effect was found for patients with high pattern separation ability. (Less)
- Abstract (Swedish)
- Mönsterseparation är en neural mekanism ansvarig för att skapa specifika, ickeöverlappande, minnesspår för stimuli som påminner om varandra. Trots denna mekanism, händer det att minnen överlappar och detta skapar ofta interferens i samband med att vi försöker plocka fram ett specifikt minne. För att reducera interferens vid framplockning aktiveras en annan mekanism, nämligen inhibition av relaterade, tävlande, minnen. Denna inhibition har antagits förklara den glömska (retrieval-induced forgetting; RIF) för de tävlande minnena, som återkommande påvisats i så kallade retrieval-practice-experiment. Även om både mönsterseparation vid inkodning och inhibition vid framplockning är relaterade till interferens, är kunskapen om sambandet dem... (More)
- Mönsterseparation är en neural mekanism ansvarig för att skapa specifika, ickeöverlappande, minnesspår för stimuli som påminner om varandra. Trots denna mekanism, händer det att minnen överlappar och detta skapar ofta interferens i samband med att vi försöker plocka fram ett specifikt minne. För att reducera interferens vid framplockning aktiveras en annan mekanism, nämligen inhibition av relaterade, tävlande, minnen. Denna inhibition har antagits förklara den glömska (retrieval-induced forgetting; RIF) för de tävlande minnena, som återkommande påvisats i så kallade retrieval-practice-experiment. Även om både mönsterseparation vid inkodning och inhibition vid framplockning är relaterade till interferens, är kunskapen om sambandet dem emellan begränsad. Dessutom finns ett stort behov av fler studier som undersöker de båda fenomenen i kliniska grupper. I denna studie fick 40 patienter med bipolär sjukdom genomföra både ett test av mönsterseparationsförmåga och ett retrieval-practice-experiment. I tillägg fick de genomföra flera test från Cambridge Neuropsychological Test Automated Battery, och svara på frågor om livsstil och affektiva symtom. Resultaten stödde tidigare antaganden om ett samband mellan mönsterseparation och fysisk aktivitet, liksom mellan mönsterseparation och selektiva serotoninåterupptagshämmare. Vidare uteblev RIF i gruppen som helhet, vilket är i linje med vad som hittats i studier av flera andra kliniska populationer. Efter att ha delat in patienterna utifrån mönsterseparationsförmåga, påvisades emellertid signifikant RIF hos gruppen med låg förmåga till mönsterseparation medan ingen RIF kunde påvisas i gruppen med hög sådan förmåga. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/4468841
- author
- Kogler Ekelund, Daniel LU
- supervisor
- organization
- course
- PSPT02 20141
- year
- 2014
- type
- H3 - Professional qualifications (4 Years - )
- subject
- keywords
- bipolar disorder, dentate gyrus, neurogenesis, retrieval-induced forgetting, retrieval, interference, pattern separation, inhibition, CANTAB, interferens, mönsterseparation, framplockning, neurogenes, gyrus dentatus, bipolär sjukdom
- language
- Swedish
- id
- 4468841
- date added to LUP
- 2014-07-01 11:41:01
- date last changed
- 2014-07-01 14:54:08
@misc{4468841,
abstract = {{Pattern separation is a neural mechanism for creating distinct, non-overlapping, memory traces for similar inputs. Despite this, memories may overlap, and this often produces interference during retrieval of a particular target memory. To reduce interference during selective retrieval another mechanism comes into play, namely inhibition of related, competing memories. This inhibition is believed to cause “retrieval-induced forgetting” (RIF) of the competing memories, which has recurrently been demonstrated by means of the retrieval-practice paradigm. Even though pattern separation at encoding and inhibition during retrieval are both related to interference, there is a sparse understanding of their mutual relationship. In addition, there is a need for further studies of these phenomena in clinical populations. In this study, 40 patients diagnosed with bipolar disorder completed a behavioral pattern separation task, as well as a retrieval-practice experiment. Four tests from the Cambridge Neuropsychological Test Automated Battery were also conducted, and patients were asked questions regarding lifestyle factors and affective symptoms. The results supported previous findings of a relationship between physical activity and pattern separation, as well as a connection between pattern separation and selective serotonin reuptake inhibitors. In accordance with previous studies on clinical populations, no RIF effect was found for the group as a whole. However, when divided according to pattern separation ability, significant RIF was found for patients with low such ability, whereas no such effect was found for patients with high pattern separation ability.}},
author = {{Kogler Ekelund, Daniel}},
language = {{swe}},
note = {{Student Paper}},
title = {{Minnesinterferens: Relationen mellan mönsterseparation och inhibitorisk kontroll vid bipolär sjukdom}},
year = {{2014}},
}