Systemic immune reactions initiated by epileptic seizures and brain inflammation
(2018) MOBN03 20172Degree Projects in Molecular Biology
- Abstract
- Epilepsy is a neurological disorder affecting around 1% of the population. It is mainly diagnosed by clinical signs and pathological electrical activity in the brain. Without these parameters, even patients themselves may not always know whether or not they experienced a seizure. Here we investigated the systemic inflammatory response following a prolonged epileptic seizure (status epilepticus; SE) or a bacterial antigen called lipopolysaccharide in the rat brain. Both pathologies lead to brain inflammation. We quantified levels of several inflammatory proteins in blood serum and in the spleen of adult male Sprague Dawley rats at different timepoints after electrically-induced SE or intrahippocampal injection of LPS. We show that we can... (More)
- Epilepsy is a neurological disorder affecting around 1% of the population. It is mainly diagnosed by clinical signs and pathological electrical activity in the brain. Without these parameters, even patients themselves may not always know whether or not they experienced a seizure. Here we investigated the systemic inflammatory response following a prolonged epileptic seizure (status epilepticus; SE) or a bacterial antigen called lipopolysaccharide in the rat brain. Both pathologies lead to brain inflammation. We quantified levels of several inflammatory proteins in blood serum and in the spleen of adult male Sprague Dawley rats at different timepoints after electrically-induced SE or intrahippocampal injection of LPS. We show that we can detect different immune-related proteins in blood and in the spleen following SE in rats. These findings could lead to the implication of a blood sample when diagnosing epilepsy, as well increase the understanding of the mechanism behind epilepsy development and progression. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/8958766
- author
- Öberg, Maria
- supervisor
- organization
- course
- MOBN03 20172
- year
- 2018
- type
- H2 - Master's Degree (Two Years)
- subject
- language
- English
- id
- 8958766
- date added to LUP
- 2018-09-14 11:01:43
- date last changed
- 2018-10-26 08:25:17
@misc{8958766, abstract = {{Epilepsy is a neurological disorder affecting around 1% of the population. It is mainly diagnosed by clinical signs and pathological electrical activity in the brain. Without these parameters, even patients themselves may not always know whether or not they experienced a seizure. Here we investigated the systemic inflammatory response following a prolonged epileptic seizure (status epilepticus; SE) or a bacterial antigen called lipopolysaccharide in the rat brain. Both pathologies lead to brain inflammation. We quantified levels of several inflammatory proteins in blood serum and in the spleen of adult male Sprague Dawley rats at different timepoints after electrically-induced SE or intrahippocampal injection of LPS. We show that we can detect different immune-related proteins in blood and in the spleen following SE in rats. These findings could lead to the implication of a blood sample when diagnosing epilepsy, as well increase the understanding of the mechanism behind epilepsy development and progression.}}, author = {{Öberg, Maria}}, language = {{eng}}, note = {{Student Paper}}, title = {{Systemic immune reactions initiated by epileptic seizures and brain inflammation}}, year = {{2018}}, }