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Exploring Inflammation and its Consequences in Chemotherapy - Inflammasome Activation in Hematopoietic Stem Cells (HSCs)

Hedberg, Oscar (2021) MOBY01 20202
Degree Projects in Molecular Biology
Popular Abstract
Inflammation Profiling in Chemotherapy


One of the methods used for treating leukemia and various types of cancer is chemotherapy that is spread over multiple cycles of treatment. The chemotherapy is toxic for the blood system and severely decreased cellular output and may leave the bone marrow (BM) impaired leading to myelosuppression. Myelosuppression is a state where the BM have problems to revitalize the bloods steady state in the body post cancer treatment.

A recent study showed that the inflammasome complex NLRP3 that is a common inflammation pathway took part of early blood population expansion in zebrafish embryos. Assembly of inflammasomes in adults blood stem cells (HSC) is unknown, and to what extent and what the... (More)
Inflammation Profiling in Chemotherapy


One of the methods used for treating leukemia and various types of cancer is chemotherapy that is spread over multiple cycles of treatment. The chemotherapy is toxic for the blood system and severely decreased cellular output and may leave the bone marrow (BM) impaired leading to myelosuppression. Myelosuppression is a state where the BM have problems to revitalize the bloods steady state in the body post cancer treatment.

A recent study showed that the inflammasome complex NLRP3 that is a common inflammation pathway took part of early blood population expansion in zebrafish embryos. Assembly of inflammasomes in adults blood stem cells (HSC) is unknown, and to what extent and what the functional consequences of such activation is unknown. In this paper we identify the inflammasome complex in HSCs and shine a light on its effect on revitalizing the bloods steady state post chemotherapy by looking into gene expression of HSCs, as well as cytokines level post chemotherapy compared with a knockout (KO) strand of mice.

Inflammation Takes Part in the Blood Systems Recovery

We found evidence that the inflammasome complex is likely expressed in the HSCs by increased gene expression follow by increased cytokine plasma levels, further the caspase-1 KO strand told us that WBC expansion occurs in cost of RBC expansion post chemotherapy.

This project is of clinical importance as any effort to speed up the recovery after chemotherapy would decrease the time under myelosuppression and increase the survival rate. Furthermore, the recovery time between each spaced session of chemotherapy is a limiting factor in treatment and shortening may contribute to optimization of the treatment.

Supervisor: Valgardur Sigurdsson
MOBY01 30 hp kandidatarbete i molekylärbiologi, 2020
Biologiska institutionen, Lunds universitet
Division of Molecular Medicine and Gene Therapy (Less)
Please use this url to cite or link to this publication:
author
Hedberg, Oscar
supervisor
organization
course
MOBY01 20202
year
type
M2 - Bachelor Degree
subject
language
English
id
9040446
date added to LUP
2021-02-15 11:33:01
date last changed
2021-02-15 11:33:01
@misc{9040446,
  author       = {{Hedberg, Oscar}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Exploring Inflammation and its Consequences in Chemotherapy - Inflammasome Activation in Hematopoietic Stem Cells (HSCs)}},
  year         = {{2021}},
}