Utveckling av Polydimetylsiloxan-Mikropartiklar för Biomedicinsk NMR
(2022) EEML05 20221Department of Biomedical Engineering
- Abstract
- Nuclear magnetic resonance spectroscopy is a technique for identifying molecular structures, compositions etc. and is widely used in many life science research fields. The purpose of this project is to synthesize PDMS microparticles with a magnetic susceptibility matching water, which makes them applicable for use in NMR of biological samples. The microparticles are intended to be used as a chromatographic medium for NMR while avoiding line broadening. The vast majority of the project was conducted at the Biomedical Center, Department of Clinical Sciences, at Lund University. The microparticles were synthesized using a needle-based microfluidics set-up. Susceptibility matching was attempted with a composite of PDMS and an additive of... (More)
- Nuclear magnetic resonance spectroscopy is a technique for identifying molecular structures, compositions etc. and is widely used in many life science research fields. The purpose of this project is to synthesize PDMS microparticles with a magnetic susceptibility matching water, which makes them applicable for use in NMR of biological samples. The microparticles are intended to be used as a chromatographic medium for NMR while avoiding line broadening. The vast majority of the project was conducted at the Biomedical Center, Department of Clinical Sciences, at Lund University. The microparticles were synthesized using a needle-based microfluidics set-up. Susceptibility matching was attempted with a composite of PDMS and an additive of metallic powder. Calculations for additive mass fraction were conducted to guide the susceptibility matching. The calculations helped guide our choice for the composition of the microparticles. Line-width of NMR spectra were used as an indicator of magnetic susceptibility matching. The synthesised microparticles provided a nearly two-fold decrease in line-width compared to the original polymer. This result indicated that the suggested additive could indeed be used for adjustment of magnetic susceptibility of PDMS. Further steps were identified to achieve a more precise matching. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9092933
- author
- Al-Sultani, Mohammad LU and Djärf, Josef LU
- supervisor
- organization
- alternative title
- Development of Polydimethylsiloxane Microparticles for Biomedical NMR
- course
- EEML05 20221
- year
- 2022
- type
- M2 - Bachelor Degree
- subject
- language
- English
- id
- 9092933
- date added to LUP
- 2022-06-30 13:38:49
- date last changed
- 2022-06-30 13:38:49
@misc{9092933, abstract = {{Nuclear magnetic resonance spectroscopy is a technique for identifying molecular structures, compositions etc. and is widely used in many life science research fields. The purpose of this project is to synthesize PDMS microparticles with a magnetic susceptibility matching water, which makes them applicable for use in NMR of biological samples. The microparticles are intended to be used as a chromatographic medium for NMR while avoiding line broadening. The vast majority of the project was conducted at the Biomedical Center, Department of Clinical Sciences, at Lund University. The microparticles were synthesized using a needle-based microfluidics set-up. Susceptibility matching was attempted with a composite of PDMS and an additive of metallic powder. Calculations for additive mass fraction were conducted to guide the susceptibility matching. The calculations helped guide our choice for the composition of the microparticles. Line-width of NMR spectra were used as an indicator of magnetic susceptibility matching. The synthesised microparticles provided a nearly two-fold decrease in line-width compared to the original polymer. This result indicated that the suggested additive could indeed be used for adjustment of magnetic susceptibility of PDMS. Further steps were identified to achieve a more precise matching.}}, author = {{Al-Sultani, Mohammad and Djärf, Josef}}, language = {{eng}}, note = {{Student Paper}}, title = {{Utveckling av Polydimetylsiloxan-Mikropartiklar för Biomedicinsk NMR}}, year = {{2022}}, }