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Chemical Gradient over Maze-Microsystem for Fungal Hyphal Growth

Lam, Sofia LU (2015) BMEL01 20151
Department of Biomedical Engineering
Abstract
The natural environment of fungal hyphae is both physically and chemically heterogeneous, nevertheless is the fungal growth often studied on a flat surface of a homogeneous medium, for example agar. With the help of the well-established techniques of microsystems, it is possible to make structures that resemble their natural habitat. With microfabrication methods obstacles can be created at the size range of a hypha (5-10 μm). These obstacles can in turn be used to manipulate individual hypha. By the principles of microfluidics, a controlled chemical gradient can be created in the culture chamber.
In this study, we have microfabricated a device that consists of physical obstacles in a form of a maze with a chemical gradient. The purpose... (More)
The natural environment of fungal hyphae is both physically and chemically heterogeneous, nevertheless is the fungal growth often studied on a flat surface of a homogeneous medium, for example agar. With the help of the well-established techniques of microsystems, it is possible to make structures that resemble their natural habitat. With microfabrication methods obstacles can be created at the size range of a hypha (5-10 μm). These obstacles can in turn be used to manipulate individual hypha. By the principles of microfluidics, a controlled chemical gradient can be created in the culture chamber.
In this study, we have microfabricated a device that consists of physical obstacles in a form of a maze with a chemical gradient. The purpose of this system is to study the growth dynamics of a hyphae and their sensing of the chemical environment. (Less)
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author
Lam, Sofia LU
supervisor
organization
course
BMEL01 20151
year
type
M2 - Bachelor Degree
subject
language
English
id
5469968
date added to LUP
2015-06-09 13:30:43
date last changed
2015-10-08 09:53:44
@misc{5469968,
  abstract     = {The natural environment of fungal hyphae is both physically and chemically heterogeneous, nevertheless is the fungal growth often studied on a flat surface of a homogeneous medium, for example agar. With the help of the well-established techniques of microsystems, it is possible to make structures that resemble their natural habitat. With microfabrication methods obstacles can be created at the size range of a hypha (5-10 μm). These obstacles can in turn be used to manipulate individual hypha. By the principles of microfluidics, a controlled chemical gradient can be created in the culture chamber.
In this study, we have microfabricated a device that consists of physical obstacles in a form of a maze with a chemical gradient. The purpose of this system is to study the growth dynamics of a hyphae and their sensing of the chemical environment.},
  author       = {Lam, Sofia},
  language     = {eng},
  note         = {Student Paper},
  title        = {Chemical Gradient over Maze-Microsystem for Fungal Hyphal Growth},
  year         = {2015},
}